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{{ Mantle cell lymphoma }}
{{Mantle cell lymphoma }}


{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{Akram}} {{AS}}


==Overview==
==Overview==
Other diagnostic studies for the diagnosis of mantle cell lymphoma include genetic testing, FISH, PCR, bone marrow aspiration, lumbar puncture, colnoscopy, upper endoscopy, cytogenetic analysis, flow chemistry, immunohistochemistry, laparoscopy, and laparatomy<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>.
Other [[diagnostic]] studies for the [[diagnosis]] of mantle cell lymphoma include [[bone marrow aspiration]], [[lumbar puncture]], [[colonoscopy]], [[upper endoscopy]], [[laparoscopy]], and [[laparotomy]].
==Other Diagnostic Studies==
==Other Diagnostic Studies==
===Genetic Testing===
Other [[diagnostic]] studies for the [[diagnosis]] of mantle cell lymphoma include:
:* Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
* [[Bone marrow aspiration]]
:* Overexpression CYCLIN D [[mRNA]]
* [[Lumbar puncture]]
:* Mutation or deletions of ''ATM gene''
* [[Colonoscopy]]  
===FISH===
* [[Upper endoscopy]]  
Diagnosis generally requires stained slides of a surgically removed part of a lymph node. Other methods are also commonly used, including cytogenetics and [[fluorescence in situ hybridization]] (FISH).
* [[Laparoscopy]] (rarely performed)
===PCR===
* [[Laparotomy]] (rarely performed)
[[Polymerase_chain_reaction|Polymerase chain reaction]] (PCR) and CER3 clonotypic primers are additional methods, but are less often used.
===Immunophenotype===
''BCL6-'', [[CD5]]+, [[CD10]]-, [[CD23]]- (or weakly positive), [[CD43]]+, FMC7+
===Bone Marrow Aspiration===
===Bone Marrow Aspiration===
Mantle cell lymphoma is a systemic disease with frequent involvement of the bone marrow and gastrointestinal tract (generally showing[[Polyposis|polyposis]] in the lining). There is also a not-uncommon leukemic phase, marked by presence in the blood. For this reason, both the peripheral blood and bone marrow are evaluated for the presence of malignant cells.
Mantle cell lymphoma is a systemic disease that can affect the extra nodal sites like the [[bone marrow]] and the [[peripheral blood]]. Therefore, [[bone marrow biopsy]] is useful in the [[diagnosis]] of [[MCL]].<ref>{{Cite journal
| author = [[Daniel A. Arber]] & [[Tracy I. George]]
| title = Bone marrow biopsy involvement by non-Hodgkin's lymphoma: frequency of lymphoma types, patterns, blood involvement, and discordance with other sites in 450 specimens
| journal = [[The American journal of surgical pathology]]
| volume = 29
| issue = 12
| pages = 1549–1557
| year = 2005
| month = December
| pmid = 16327427
}}</ref>
===Lumbar Puncture===
===Lumbar Puncture===
In some patients with the blastic variant, lumbar puncture is done to evaluate the spinal fluid for involvement.
In some patients with the blastic variant, [[lumbar puncture]] is done to evaluate the [[spinal fluid]] for [[CNS]] involvement.<ref>https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf</ref>
===Colonoscopy===
===Colonoscopy===
Since mantle cell lymphoma may present a lymphomatous polyposis coli and colon involvement is common, colonoscopy is now considered a routine part of the evaluation.  
Lymphomatous polyposis coli and [[colon]] involvement is common in [[Mantle cell lymphoma|MCL]], so, [[colonoscopy]] can be helpful in the diagnosis of [[Mantle cell lymphoma|MCL]].<ref>https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf</ref>
===Upper Endoscopy===
===Upper Endoscopy===
Upper endoscopy may be helpful in selected cases.
[[Upper endoscopy]] may be helpful in selected cases involving the [[gastrointestinal tract]].
===Cytogenetic analysis===
===Flow cytometry===
===Immunohistochemistry===
===Laparoscopy (rarely performed)===
===Laparotomy (rarely performed)===


==References==
==References==
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[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Hematology]]
[[Category:Immunology]]

Latest revision as of 20:20, 7 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]

Overview

Other diagnostic studies for the diagnosis of mantle cell lymphoma include bone marrow aspiration, lumbar puncture, colonoscopy, upper endoscopy, laparoscopy, and laparotomy.

Other Diagnostic Studies

Other diagnostic studies for the diagnosis of mantle cell lymphoma include:

Bone Marrow Aspiration

Mantle cell lymphoma is a systemic disease that can affect the extra nodal sites like the bone marrow and the peripheral blood. Therefore, bone marrow biopsy is useful in the diagnosis of MCL.[1]

Lumbar Puncture

In some patients with the blastic variant, lumbar puncture is done to evaluate the spinal fluid for CNS involvement.[2]

Colonoscopy

Lymphomatous polyposis coli and colon involvement is common in MCL, so, colonoscopy can be helpful in the diagnosis of MCL.[3]

Upper Endoscopy

Upper endoscopy may be helpful in selected cases involving the gastrointestinal tract.

References

  1. ↑ Daniel A. Arber & Tracy I. George (2005). "Bone marrow biopsy involvement by non-Hodgkin's lymphoma: frequency of lymphoma types, patterns, blood involvement, and discordance with other sites in 450 specimens". The American journal of surgical pathology. 29 (12): 1549–1557. PMID 16327427. Unknown parameter |month= ignored (help)
  2. ↑ https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf
  3. ↑ https://www.nccn.org/professionals/physician_gls/pdf/b-cell.pdf

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