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{{ | '''Pre-mRNA-processing factor 6''' is a [[protein]] that in humans is encoded by the ''PRPF6'' [[gene]].<ref name="pmid10561546">{{cite journal |vauthors=Nishikimi A, Mukai J, Kioka N, Yamada M | title = A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors | journal = Biochim Biophys Acta | volume = 1435 | issue = 1-2 | pages = 147–52 |date=January 2000 | pmid = 10561546 | pmc = | doi = 10.1016/s0167-4838(99)00203-4}}</ref><ref name="pmid10788320">{{cite journal |vauthors=Makarov EM, Makarova OV, Achsel T, Luhrmann R | title = The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions | journal = J Mol Biol | volume = 298 | issue = 4 | pages = 567–75 |date=June 2000 | pmid = 10788320 | pmc = | doi = 10.1006/jmbi.2000.3685 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=24148| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.<ref name="entrez" | | summary_text = The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
PRPF6 has been shown to [[Protein-protein interaction|interact]] with [[TXNL4B]],<ref name=pmid15161931>{{cite journal |last=Sun |first=Xiaojing |authorlink= |author2=Zhang Hua |author3=Wang Dan |author4=Ma Dalong |author5=Shen Yan |author6=Shang Yongfeng |date=July 2004 |title=DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression |journal=J. Biol. Chem. |volume=279 |issue=31 |pages=32839–47 |publisher= |location = United States| issn = 0021-9258| pmid = 15161931 |doi = 10.1074/jbc.M402522200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[ARAF]]<ref name=pmid12620389>{{cite journal |doi=10.1016/S0888-7543(02)00008-3 |last=Yuryev |first=Anton |authorlink= |author2=Wennogle Lawrence P |date=February 2003 |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis |journal=Genomics |volume=81 |issue=2 |pages=112–25 |publisher= |location = United States| issn = 0888-7543| pmid = 12620389 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10848612>{{cite journal |doi=10.1128/MCB.20.13.4870-4878.2000 |last=Yuryev |first=A |authorlink= |author2=Ono M |author3=Goff S A |author4=Macaluso F |author5=Wennogle L P |date=July 2000 |title=Isoform-specific localization of A-RAF in mitochondria |journal=Mol. Cell. Biol. |volume=20 |issue=13 |pages=4870–8 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10848612 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=85938 }}</ref> and [[Androgen receptor]].<ref name=pmid12039962>{{cite journal |last=Zhao |first=Yue |authorlink= |author2=Goto Kiminobu |author3=Saitoh Masayuki |author4=Yanase Toshihiko |author5=Nomura Masatoshi |author6=Okabe Taijiro |author7=Takayanagi Ryoichi |author8=Nawata Hajime |date=August 2002 |title=Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor |journal=J. Biol. Chem. |volume=277 |issue=33 |pages=30031–9 |publisher= |location = United States| issn = 0021-9258| pmid = 12039962 |doi = 10.1074/jbc.M203811200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | *{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }} | ||
*{{cite journal | *{{cite journal |vauthors=Yuryev A, Ono M, Goff SA, etal |title=Isoform-specific localization of A-RAF in mitochondria. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4870–8 |year= 2000 |pmid= 10848612 |doi= 10.1128/MCB.20.13.4870-4878.2000| pmc=85938 }} | ||
*{{cite journal | *{{cite journal |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D }} | ||
*{{cite journal | *{{cite journal |vauthors=Jurica MS, Licklider LJ, Gygi SR, etal |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi= 10.1017/S1355838202021088| pmc=1370266 }} | ||
*{{cite journal | *{{cite journal |vauthors=Zhao Y, Goto K, Saitoh M, etal |title=Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30031–9 |year= 2002 |pmid= 12039962 |doi= 10.1074/jbc.M203811200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | | *{{cite journal |vauthors=Yuryev A, Wennogle LP |title=Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis. |journal=Genomics |volume=81 |issue= 2 |pages= 112–25 |year= 2003 |pmid= 12620389 |doi=10.1016/S0888-7543(02)00008-3 }} | ||
*{{cite journal | *{{cite journal |vauthors=Goto K, Zhao Y, Saito M, etal |title=Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 201–8 |year= 2003 |pmid= 12943705 |doi=10.1016/S0960-0760(03)00196-1 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
*{{cite journal | *{{cite journal |vauthors=Will CL, Schneider C, Hossbach M, etal |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. |journal=RNA |volume=10 |issue= 6 |pages= 929–41 |year= 2004 |pmid= 15146077 |doi= 10.1261/rna.7320604| pmc=1370585 }} | ||
*{{cite journal | *{{cite journal |vauthors=Sun X, Zhang H, Wang D, etal |title=DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32839–47 |year= 2004 |pmid= 15161931 |doi= 10.1074/jbc.M402522200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | *{{cite journal |vauthors=Laggerbauer B, Liu S, Makarov E, etal |title=The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation. |journal=RNA |volume=11 |issue= 5 |pages= 598–608 |year= 2005 |pmid= 15840814 |doi= 10.1261/rna.2300805 | pmc=1370748 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Batsché E, Yaniv M, Muchardt C |title=The human SWI/SNF subunit Brm is a regulator of alternative splicing. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 1 |pages= 22–9 |year= 2006 |pmid= 16341228 |doi= 10.1038/nsmb1030 }} | ||
*{{cite journal | *{{cite journal |vauthors=Fan S, Goto K, Chen G, etal |title=Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 192–201 |year= 2006 |pmid= 16414017 |doi= 10.1016/j.bbrc.2005.12.167 }} | ||
*{{cite journal | *{{cite journal |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
==External links== | |||
* [https://www.ncbi.nlm.nih.gov/books/NBK1417/ GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview] | |||
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{{Post transcriptional modification}} | |||
[[Category:Spliceosome]] | |||
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Latest revision as of 07:16, 10 January 2019
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.[1][2][3]
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.[3]
Interactions
PRPF6 has been shown to interact with TXNL4B,[4] ARAF[5][6] and Androgen receptor.[7]
References
- ↑ Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors". Biochim Biophys Acta. 1435 (1–2): 147–52. doi:10.1016/s0167-4838(99)00203-4. PMID 10561546.
- ↑ Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". J Mol Biol. 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320.
- ↑ 3.0 3.1 "Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)".
- ↑ Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. United States. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931.
- ↑ Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. United States. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389.
- ↑ Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. UNITED STATES. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612.
- ↑ Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. United States. 277 (33): 30031–9. doi:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Yuryev A, Ono M, Goff SA, et al. (2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. PMC 85938. PMID 10848612.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
- Zhao Y, Goto K, Saitoh M, et al. (2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. 277 (33): 30031–9. doi:10.1074/jbc.M203811200. PMID 12039962.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics. 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
- Goto K, Zhao Y, Saito M, et al. (2003). "Activation function-1 domain of androgen receptor contributes to the interaction between two distinct subnuclear compartments". J. Steroid Biochem. Mol. Biol. 85 (2–5): 201–8. doi:10.1016/S0960-0760(03)00196-1. PMID 12943705.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
- Sun X, Zhang H, Wang D, et al. (2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. 279 (31): 32839–47. doi:10.1074/jbc.M402522200. PMID 15161931.
- Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Laggerbauer B, Liu S, Makarov E, et al. (2005). "The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation". RNA. 11 (5): 598–608. doi:10.1261/rna.2300805. PMC 1370748. PMID 15840814.
- Batsché E, Yaniv M, Muchardt C (2006). "The human SWI/SNF subunit Brm is a regulator of alternative splicing". Nat. Struct. Mol. Biol. 13 (1): 22–9. doi:10.1038/nsmb1030. PMID 16341228.
- Fan S, Goto K, Chen G, et al. (2006). "Identification of the functional domains of ANT-1, a novel coactivator of the androgen receptor". Biochem. Biophys. Res. Commun. 341 (1): 192–201. doi:10.1016/j.bbrc.2005.12.167. PMID 16414017.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
External links
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