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{{Infobox_gene}}
{{Infobox_gene}}


'''Defensin, alpha  4''' ('''DEFA4'''), also known as '''neutrophil defensin 4''' or '''HNP4''', is a human [[defensin]] [[peptide]] that is encoded by the ''DEFA4'' [[gene]].<ref name="entrez">{{Cite web| title = Entrez Gene: DEFA4; defensin, alpha 4, corticostatin (''Homo sapiens'') | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1669| accessdate = }}</ref><ref name="pmid15317502">{{Cite journal| vauthors=Wu Z, Ericksen B, Tucker K |title=Synthesis and characterization of human alpha-defensins 4-6. |journal=J Pept Res. |volume=64 |issue= 3 |pages= 118–25 |year= 2004 |pmid= 15317502 |doi= 10.1111/j.1399-3011.2004.00179.x|display-authors=etal}}</ref> HNP4 is expressed in the [[Granule (cell biology)|granules]] of the [[neutrophil]] where it defends the host against [[bacteria]]<ref name="pmid15616305">{{Cite journal| vauthors=Ericksen B, Wu Z, Lu W, Lehrer RI |title=Antibacterial Activity and Specificity of the Six Human α-Defensins |journal= Antimicrob. Agents Chemother. |volume=49 |issue= 1 |pages= 269–75 |year= 2005 |pmid= 15616305 |pmc= 538877 |doi= 10.1128/AAC.49.1.269-275.2005}}</ref> and [[viruses]].<ref name="pmid15620707">{{Cite journal| vauthors = Wu Z, Cocchi F, Gentles D| title = Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro | journal = FEBS Lett | volume = 579| issue = 1 | pages = 162–6 |date=3 January 2005| pmid = 15620707| pmc =  | doi = 10.1016/j.febslet.2004.11.062 |display-authors=etal}}</ref>
'''Defensin, alpha  4''' ('''DEFA4'''), also known as '''neutrophil defensin 4''' or '''HNP4''', is a human [[defensin]] [[peptide]] that is encoded by the ''DEFA4'' [[gene]].<ref name="entrez">{{Cite web| title = Entrez Gene: DEFA4; defensin, alpha 4, corticostatin (''Homo sapiens'') | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1669| accessdate = }}</ref><ref name="pmid15317502">{{Cite journal| vauthors=Wu Z, Ericksen B, Tucker K |title=Synthesis and characterization of human alpha-defensins 4-6. |journal=J Pept Res |volume=64 |issue= 3 |pages= 118–25 |year= 2004 |pmid= 15317502 |doi= 10.1111/j.1399-3011.2004.00179.x|display-authors=etal}}</ref> HNP4 is expressed in the [[Granule (cell biology)|granules]] of the [[neutrophil]] where it defends the host against [[bacteria]]<ref name="pmid15616305">{{Cite journal| vauthors=Ericksen B, Wu Z, Lu W, Lehrer RI |title=Antibacterial Activity and Specificity of the Six Human α-Defensins |journal= Antimicrob. Agents Chemother. |volume=49 |issue= 1 |pages= 269–75 |year= 2005 |pmid= 15616305 |pmc= 538877 |doi= 10.1128/AAC.49.1.269-275.2005}}</ref> and [[viruses]].<ref name="pmid15620707">{{Cite journal| vauthors = Wu Z, Cocchi F, Gentles D| title = Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro | journal = FEBS Lett | volume = 579| issue = 1 | pages = 162–6 |date=3 January 2005| pmid = 15620707| pmc =  | doi = 10.1016/j.febslet.2004.11.062 |display-authors=etal}}</ref>


==Function==
==Function==
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{{DEFAULTSORT:Defa4}}
{{DEFAULTSORT:Defa4}}
[[Category:Defensins]]




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{{Gene-8-stub}}

Latest revision as of 08:47, 10 January 2019

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SpeciesHumanMouse
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Wikidata
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Defensin, alpha 4 (DEFA4), also known as neutrophil defensin 4 or HNP4, is a human defensin peptide that is encoded by the DEFA4 gene.[1][2] HNP4 is expressed in the granules of the neutrophil where it defends the host against bacteria[3] and viruses.[4]

Function

Defensins are a peptide family of cytotoxic microbicides involved in innate immunity.[5] Members of the defensin family are distinguished by a conserved six-cysteine motif. Several human alpha defensin genes including HNP4 are clustered on chromosome 8. DEFA4 differs from other defensin genes by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. HNP4 inhibits corticotropin-stimulated corticosterone production.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: DEFA4; defensin, alpha 4, corticostatin (Homo sapiens)".
  2. ↑ Wu Z, Ericksen B, Tucker K, et al. (2004). "Synthesis and characterization of human alpha-defensins 4-6". J Pept Res. 64 (3): 118–25. doi:10.1111/j.1399-3011.2004.00179.x. PMID 15317502.
  3. ↑ Ericksen B, Wu Z, Lu W, Lehrer RI (2005). "Antibacterial Activity and Specificity of the Six Human α-Defensins". Antimicrob. Agents Chemother. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877. PMID 15616305.
  4. ↑ Wu Z, Cocchi F, Gentles D, et al. (3 January 2005). "Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro". FEBS Lett. 579 (1): 162–6. doi:10.1016/j.febslet.2004.11.062. PMID 15620707.
  5. ↑ T Ganz; M E Selsted; D Szklarek; et al. (1985). "Defensins. Natural peptide antibiotics of human neutrophils". J Clin Invest. 76 (4): 1427–1435. doi:10.1172/JCI112120. PMC 424093. PMID 2997278.

Further reading


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