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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''BAG family molecular chaperone regulator 4''' is a [[protein]] that in humans is encoded by the ''BAG4'' [[gene]].<ref name="pmid9873016">{{cite journal |vauthors=Takayama S, Xie Z, Reed JC | title = An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators | journal = J Biol Chem | volume = 274 | issue = 2 | pages = 781–6 |date=Feb 1999 | pmid = 9873016 | pmc =  | doi =10.1074/jbc.274.2.781  }}</ref><ref name="pmid9915703">{{cite journal |vauthors=Jiang Y, Woronicz JD, Liu W, Goeddel DV | title = Prevention of constitutive TNF receptor 1 signaling by silencer of death domains | journal = Science | volume = 283 | issue = 5401 | pages = 543–6 |date=Feb 1999 | pmid = 9915703 | pmc = | doi =10.1126/science.283.5401.543  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: BAG4 BCL2-associated athanogene 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9530| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_BAG4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1m62.
| PDB = {{PDB2|1m62}}, {{PDB2|1m7k}}
| Name = BCL2-associated athanogene 4
| HGNCid = 940
| Symbol = BAG4
| AltSymbols =; BAG-4; SODD
| OMIM = 603884
| ECnumber = 
| Homologene = 31270
| MGIid = 1914634
| GeneAtlas_image1 = PBB_GE_BAG4_219624_at_tn.png
| Function = {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9530
    | Hs_Ensembl = ENSG00000156735
    | Hs_RefseqProtein = NP_004865
    | Hs_RefseqmRNA = NM_004874
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 38153469
    | Hs_GenLoc_end = 38189966
    | Hs_Uniprot = O95429
    | Mm_EntrezGene = 67384
    | Mm_Ensembl = ENSMUSG00000037316
    | Mm_RefseqmRNA = NM_026121
    | Mm_RefseqProtein = NP_080397
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 27230081
    | Mm_GenLoc_end = 27250754
    | Mm_Uniprot = Q8CI61
  }}
}}
'''BCL2-associated athanogene 4''', also known as '''BAG4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BAG4 BCL2-associated athanogene 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9530| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[BAG1]]-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell [[apoptosis]] and growth related proteins including [[BCL-2]], Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the [[heat shock protein]] 70 kDa family. This protein contains a [[BAG domain]] near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of [[tumor necrosis factor receptor]] type 1 (TNF-R1) and [[death receptor]]-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
==Interactions==
| summary_text = The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.<ref name="entrez">{{cite web | title = Entrez Gene: BAG4 BCL2-associated athanogene 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9530| accessdate = }}</ref>
BAG4 has been shown to [[Protein-protein interaction|interact]] with:
}}
* [[APOBEC1]],<ref name = pmid14559896>{{cite journal | date = Dec 2003 |vauthors=Lau PP, Chan L | title = Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52988–96 | pmid = 14559896 | doi = 10.1074/jbc.M310153200}}</ref>
* [[HSPA8]],<ref name = pmid11909948>{{cite journal | date = Apr 2002 |vauthors=Miki K, Eddy EM | title = Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain | journal = Mol. Cell. Biol. | volume = 22 | issue = 8 | pages = 2536–43 | pmid = 11909948 | pmc = 133739 | doi = 10.1128/MCB.22.8.2536-2543.2002}}</ref> and
* [[TNFRSF1A]].<ref name = pmid9915703 /><ref name = pmid11909948/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|BAG4}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | author=Riley BM |title=A Genome-Wide Linkage Scan for Cleft Lip and Cleft Palate Identifies a Novel Locus on 8p11-23 |journal=Am. J. Med. Genet. A |volume=143 |issue= 8 |pages= 846–52 |year= 2007 |pmid= 17366557 |doi= 10.1002/ajmg.a.31673 | pmc=2570349  |name-list-format=vanc| author2=Schultz RE  | author3=Cooper ME  | display-authors=3  | last4=Goldstein-Mchenry  | first4=T.  | last5=Daack-Hirsch  | first5=S.  | last6=Lee  | first6=K.T.  | last7=Dragan  | first7=E.  | last8=Vieira  | first8=A.R.  | last9=Lidral  | first9=A.C. }}
| citations =
*{{cite journal  | author=Yang ZQ |title=Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11632–43 |year= 2007 |pmid= 17178857 |doi= 10.1158/0008-5472.CAN-06-2946 |name-list-format=vanc| author2=Streicher KL  | author3=Ray ME  | display-authors=3  | last4=Abrams  | first4=J.  | last5=Ethier  | first5=S. P. }}
*{{cite journal  | author=Riley BM, Schultz RE, Cooper ME, ''et al.'' |title=A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23. |journal=Am. J. Med. Genet. A |volume=143 |issue= 8 |pages= 846-52 |year= 2007 |pmid= 17366557 |doi= 10.1002/ajmg.a.31673 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Yang ZQ, Streicher KL, Ray ME, ''et al.'' |title=Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer. |journal=Cancer Res. |volume=66 |issue= 24 |pages= 11632-43 |year= 2007 |pmid= 17178857 |doi= 10.1158/0008-5472.CAN-06-2946 }}
*{{cite journal  |vauthors=Lau PP, Chan L |title=Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52988–96 |year= 2004 |pmid= 14559896 |doi= 10.1074/jbc.M310153200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Al-Lamki RS |title=Expression of Silencer of Death Domains and Death-Receptor-3 in Normal Human Kidney and in Rejecting Renal Transplants |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 401–11 |year= 2003 |pmid= 12875962 |doi= 10.1016/S0002-9440(10)63670-X| pmc=1868232  |name-list-format=vanc| author2=Wang J  | author3=Thiru S  | display-authors=3  | last4=Pritchard  | first4=NR  | last5=Bradley  | first5=JA  | last6=Pober  | first6=JS  | last7=Bradley  | first7=JR }}
*{{cite journal  | author=Lau PP, Chan L |title=Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52988-96 |year= 2004 |pmid= 14559896 |doi= 10.1074/jbc.M310153200 }}
*{{cite journal  |vauthors=Eichholtz-Wirth H, Fritz E, Wolz L |title=Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both TNFR1- and CD95-dependent cell death pathways |journal=Cancer Lett. |volume=194 |issue= 1 |pages= 81–9 |year= 2003 |pmid= 12706861 |doi=10.1016/S0304-3835(03)00009-0 }}
*{{cite journal  | author=Al-Lamki RS, Wang J, Thiru S, ''et al.'' |title=Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants. |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 401-11 |year= 2003 |pmid= 12875962 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Eichholtz-Wirth H, Fritz E, Wolz L |title=Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both TNFR1- and CD95-dependent cell death pathways. |journal=Cancer Lett. |volume=194 |issue= 1 |pages= 81-9 |year= 2003 |pmid= 12706861 |doi=  }}
*{{cite journal  | author=Briknarová K |title=BAG4/SODD protein contains a short BAG domain |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 31172–8 |year= 2002 |pmid= 12058034 |doi= 10.1074/jbc.M202792200 |name-list-format=vanc| author2=Takayama S  | author3=Homma S  | display-authors=3  | last4=Baker  | first4=K  | last5=Cabezas  | first5=E  | last6=Hoyt  | first6=DW  | last7=Li  | first7=Z  | last8=Satterthwait  | first8=AC  | last9=Ely  | first9=KR }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Eichholtz-Wirth H, Sagan D |title=Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells |journal=Anticancer Res. |volume=22 |issue= 1A |pages= 235–40 |year= 2002 |pmid= 12017295 |doi=  }}
*{{cite journal  | author=Briknarová K, Takayama S, Homma S, ''et al.'' |title=BAG4/SODD protein contains a short BAG domain. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 31172-8 |year= 2002 |pmid= 12058034 |doi= 10.1074/jbc.M202792200 }}
*{{cite journal  | author=Antoku K |title=Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1003–10 |year= 2001 |pmid= 11527400 |doi= 10.1006/bbrc.2001.5512 |name-list-format=vanc| author2=Maser RS  | author3=Scully WJ  | display-authors=3  | last4=Delach  | first4=Scott M.  | last5=Johnson  | first5=Daniel E. }}
*{{cite journal  | author=Eichholtz-Wirth H, Sagan D |title=Altered signaling of TNFalpha-TNFR1 and SODD/BAG4 is responsible for radioresistance in human HT-R15 cells. |journal=Anticancer Res. |volume=22 |issue= 1A |pages= 235-40 |year= 2002 |pmid= 12017295 |doi=  }}
*{{cite journal  | author=Frisch SM |title=Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis |journal=Curr. Biol. |volume=9 |issue= 18 |pages= 1047–9 |year= 2000 |pmid= 10508612 |doi=10.1016/S0960-9822(99)80455-2  }}
*{{cite journal  | author=Antoku K, Maser RS, Scully WJ, ''et al.'' |title=Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 5 |pages= 1003-10 |year= 2001 |pmid= 11527400 |doi= 10.1006/bbrc.2001.5512 }}
*{{cite journal  | author=Frisch SM |title=Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikis. |journal=Curr. Biol. |volume=9 |issue= 18 |pages= 1047-9 |year= 2000 |pmid= 10508612 |doi= }}
*{{cite journal  | author=Jiang Y, Woronicz JD, Liu W, Goeddel DV |title=Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. |journal=Science |volume=283 |issue= 5401 |pages= 543-6 |year= 1999 |pmid= 9915703 |doi=  }}
*{{cite journal  | author=Takayama S, Xie Z, Reed JC |title=An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 781-6 |year= 1999 |pmid= 9873016 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=9530}}
{{WikiDoc Sources}}
 
 
{{gene-8-stub}}
 
[[Category:Co-chaperones]]

Latest revision as of 08:49, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

BAG family molecular chaperone regulator 4 is a protein that in humans is encoded by the BAG4 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.[3]

Interactions

BAG4 has been shown to interact with:

References

  1. ↑ Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem. 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.
  2. ↑ 2.0 2.1 Jiang Y, Woronicz JD, Liu W, Goeddel DV (Feb 1999). "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains". Science. 283 (5401): 543–6. doi:10.1126/science.283.5401.543. PMID 9915703.
  3. ↑ 3.0 3.1 "Entrez Gene: BAG4 BCL2-associated athanogene 4".
  4. ↑ Lau PP, Chan L (Dec 2003). "Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing". J. Biol. Chem. 278 (52): 52988–96. doi:10.1074/jbc.M310153200. PMID 14559896.
  5. ↑ 5.0 5.1 Miki K, Eddy EM (Apr 2002). "Tumor necrosis factor receptor 1 is an ATPase regulated by silencer of death domain". Mol. Cell. Biol. 22 (8): 2536–43. doi:10.1128/MCB.22.8.2536-2543.2002. PMC 133739. PMID 11909948.

External links

Further reading


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