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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein MCM10 homolog''' is a [[protein]] that in humans is encoded by the ''MCM10'' [[gene]].<ref name="pmid11095689">{{cite journal | vauthors = Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F | title = The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase | journal = Nucleic Acids Res. | volume = 28 | issue = 23 | pages = 4769–77  | date = Dec 2000 | pmid = 11095689 | pmc = 115166 | doi = 10.1093/nar/28.23.4769 }}</ref><ref name="pmid17699597">{{cite journal | vauthors = Chattopadhyay S, Bielinsky AK | title = Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication | journal = Mol. Biol. Cell | volume = 18 | issue = 10 | pages = 4085–95  | date = Sep 2007 | pmid = 17699597 | pmc = 1995709 | doi = 10.1091/mbc.E06-12-1148 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MCM10 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55388| accessdate = }}</ref> It is essential for activation of the Cdc45:[[Minichromosome maintenance|Mcm2-7]]:[[GINS (protein complex)|GINS]] helicase, and thus required for proper DNA replication.<ref>{{cite journal | vauthors = Thu YM, Bielinsky AK | title = MCM10: one tool for all—Integrity, maintenance and damage control | journal = Seminars in Cell & Developmental Biology | volume = 30 | pages = 121–30 | date = June 2014 | pmid = 24662891 | doi = 10.1016/j.semcdb.2014.03.017 | pmc = 4043890 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)
| HGNCid = 18043
| Symbol = MCM10
| AltSymbols =; CNA43; MGC126776; PRO2249
| OMIM = 609357
| ECnumber = 
| Homologene = 41275
| MGIid = 1917274
| GeneAtlas_image1 = PBB_GE_MCM10_220651_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55388
    | Hs_Ensembl = ENSG00000065328
    | Hs_RefseqProtein = NP_060988
    | Hs_RefseqmRNA = NM_018518
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 13243587
    | Hs_GenLoc_end = 13293110
    | Hs_Uniprot = 
    | Mm_EntrezGene = 70024
    | Mm_Ensembl = ENSMUSG00000026669
    | Mm_RefseqmRNA = NM_027290
    | Mm_RefseqProtein = NP_081566
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 4906986
    | Mm_GenLoc_end = 4929616
    | Mm_Uniprot = 
  }}
}}
'''MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)''', also known as '''MCM10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MCM10 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55388| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[protein]] encoded by this gene is one of the highly conserved [[mini-chromosome maintenance]] proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The [[protein complex]] formed by MCM proteins is a key component of the [[pre-replication complex]] (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a [[cell cycle]]-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: MCM10 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55388| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MCM10 has been shown to [[Protein-protein interaction|interact]] with [[ORC2L]].<ref name=pmid11095689 />
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Morimoto S | title = [Abnormal myocardial contractile regulation mechanism in familial hypertrophic and dilated cardiomyopathies--functional analysis of molecular mutant troponin in in-vitro] | journal = Fukuoka Igaku Zasshi | volume = 93 | issue = 1 | pages = 1–5 | year = 2002 | pmid = 11889827 | doi =  }}
| citations =
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Morimoto S |title=[Abnormal myocardial contractile regulation mechanism in familial hypertrophic and dilated cardiomyopathies--functional analysis of molecular mutant troponin in in-vitro] |journal=Fukuoka Igaku Zasshi |volume=93 |issue= 1 |pages= 1-5 |year= 2002 |pmid= 11889827 |doi=  }}
* {{cite journal | vauthors = Izumi M, Yatagai F, Hanaoka F | title = Cell cycle-dependent proteolysis and phosphorylation of human Mcm10 | journal = J. Biol. Chem. | volume = 276 | issue = 51 | pages = 48526–31 | year = 2001 | pmid = 11602595 | doi = 10.1074/jbc.M107190200 }}
*{{cite journal | author=Izumi M, Yanagi K, Mizuno T, ''et al.'' |title=The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. |journal=Nucleic Acids Res. |volume=28 |issue= 23 |pages= 4769-77 |year= 2001 |pmid= 11095689 |doi=  }}
* {{cite journal | vauthors = Wohlschlegel JA, Dhar SK, Prokhorova TA, Dutta A, Walter JC | title = Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45 | journal = Mol. Cell | volume = 9 | issue = 2 | pages = 233–40 | year = 2002 | pmid = 11864598 | doi = 10.1016/S1097-2765(02)00456-2 }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Christensen TW, Tye BK | title = Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation | journal = Mol. Biol. Cell | volume = 14 | issue = 6 | pages = 2206–15 | year = 2003 | pmid = 12808023 | pmc = 194871 | doi = 10.1091/mbc.E02-11-0706 }}
*{{cite journal | author=Izumi M, Yatagai F, Hanaoka F |title=Cell cycle-dependent proteolysis and phosphorylation of human Mcm10. |journal=J. Biol. Chem. |volume=276 |issue= 51 |pages= 48526-31 |year= 2002 |pmid= 11602595 |doi= 10.1074/jbc.M107190200 }}
* {{cite journal | vauthors = Cook CR, Kung G, Peterson FC, Volkman BF, Lei M | title = A novel zinc finger is required for Mcm10 homocomplex assembly | journal = J. Biol. Chem. | volume = 278 | issue = 38 | pages = 36051–8 | year = 2003 | pmid = 12844493 | doi = 10.1074/jbc.M306049200 }}
*{{cite journal | author=Wohlschlegel JA, Dhar SK, Prokhorova TA, ''et al.'' |title=Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45. |journal=Mol. Cell |volume=9 |issue= 2 |pages= 233-40 |year= 2002 |pmid= 11864598 |doi= }}
* {{cite journal | vauthors = Izumi M, Yatagai F, Hanaoka F | title = Localization of human Mcm10 is spatially and temporally regulated during the S phase | journal = J. Biol. Chem. | volume = 279 | issue = 31 | pages = 32569–77 | year = 2004 | pmid = 15136575 | doi = 10.1074/jbc.M314017200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Yoshida K, Inoue I | title = Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor | journal = Oncogene | volume = 23 | issue = 37 | pages = 6250–60 | year = 2004 | pmid = 15195143 | doi = 10.1038/sj.onc.1207829 }}
*{{cite journal | author=Christensen TW, Tye BK |title=Drosophila MCM10 interacts with members of the prereplication complex and is required for proper chromosome condensation. |journal=Mol. Biol. Cell |volume=14 |issue= 6 |pages= 2206-15 |year= 2004 |pmid= 12808023 |doi= 10.1091/mbc.E02-11-0706 }}
* {{cite journal | vauthors = Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J | title = Self-assembling protein microarrays | journal = Science | volume = 305 | issue = 5680 | pages = 86–90 | year = 2004 | pmid = 15232106 | doi = 10.1126/science.1097639 }}
*{{cite journal | author=Cook CR, Kung G, Peterson FC, ''et al.'' |title=A novel zinc finger is required for Mcm10 homocomplex assembly. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36051-8 |year= 2003 |pmid= 12844493 |doi= 10.1074/jbc.M306049200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Zhu W, Ukomadu C, Jha S, Senga T, Dhar SK, Wohlschlegel JA, Nutt LK, Kornbluth S, Dutta A | title = Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication | journal = Genes Dev. | volume = 21 | issue = 18 | pages = 2288–99 | year = 2007 | pmid = 17761813 | pmc = 1973143 | doi = 10.1101/gad.1585607 }}
*{{cite journal  | author=Izumi M, Yatagai F, Hanaoka F |title=Localization of human Mcm10 is spatially and temporally regulated during the S phase. |journal=J. Biol. Chem. |volume=279 |issue= 31 |pages= 32569-77 |year= 2004 |pmid= 15136575 |doi= 10.1074/jbc.M314017200 }}
* {{cite journal | vauthors = Robertson PD, Warren EM, Zhang H, Friedman DB, Lary JW, Cole JL, Tutter AV, Walter JC, Fanning E, Eichman BF | title = Domain architecture and biochemical characterization of vertebrate Mcm10 | journal = J. Biol. Chem. | volume = 283 | issue = 6 | pages = 3338–48 | year = 2008 | pmid = 18065420 | pmc = 2753450 | doi = 10.1074/jbc.M706267200 }}
*{{cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
* {{cite journal | vauthors = Warren EM, Vaithiyalingam S, Haworth J, Greer B, Bielinsky AK, Chazin WJ, Eichman BF | title = Structural basis for DNA binding by replication initiator Mcm10 | journal = Structure | volume = 16 | issue = 12 | pages = 1892–901 | year = 2008 | pmid = 19081065 | pmc = 2636851 | doi = 10.1016/j.str.2008.10.005 }}
*{{cite journal  | author=Yoshida K, Inoue I |title=Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor. |journal=Oncogene |volume=23 |issue= 37 |pages= 6250-60 |year= 2004 |pmid= 15195143 |doi= 10.1038/sj.onc.1207829 }}
*{{cite journal | author=Ramachandran N, Hainsworth E, Bhullar B, ''et al.'' |title=Self-assembling protein microarrays. |journal=Science |volume=305 |issue= 5680 |pages= 86-90 |year= 2004 |pmid= 15232106 |doi= 10.1126/science.1097639 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Chattopadhyay S, Bielinsky AK |title=Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. |journal=Mol. Biol. Cell |volume=18 |issue= 10 |pages= 4085-95 |year= 2007 |pmid= 17699597 |doi= 10.1091/mbc.E06-12-1148 }}
*{{cite journal | author=Zhu W, Ukomadu C, Jha S, ''et al.'' |title=Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication. |journal=Genes Dev. |volume=21 |issue= 18 |pages= 2288-99 |year= 2007 |pmid= 17761813 |doi= 10.1101/gad.1585607 }}
}}
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{{refend}}


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Latest revision as of 22:02, 15 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein MCM10 homolog is a protein that in humans is encoded by the MCM10 gene.[1][2][3] It is essential for activation of the Cdc45:Mcm2-7:GINS helicase, and thus required for proper DNA replication.[4]

Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.[3]

Interactions

MCM10 has been shown to interact with ORC2L.[1]

References

  1. ↑ 1.0 1.1 Izumi M, Yanagi K, Mizuno T, Yokoi M, Kawasaki Y, Moon KY, Hurwitz J, Yatagai F, Hanaoka F (Dec 2000). "The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase". Nucleic Acids Res. 28 (23): 4769–77. doi:10.1093/nar/28.23.4769. PMC 115166. PMID 11095689.
  2. ↑ Chattopadhyay S, Bielinsky AK (Sep 2007). "Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication". Mol. Biol. Cell. 18 (10): 4085–95. doi:10.1091/mbc.E06-12-1148. PMC 1995709. PMID 17699597.
  3. ↑ 3.0 3.1 "Entrez Gene: MCM10 MCM10 minichromosome maintenance deficient 10 (S. cerevisiae)".
  4. ↑ Thu YM, Bielinsky AK (June 2014). "MCM10: one tool for all—Integrity, maintenance and damage control". Seminars in Cell & Developmental Biology. 30: 121–30. doi:10.1016/j.semcdb.2014.03.017. PMC 4043890. PMID 24662891.

Further reading


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