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'''Suppressor of cytokine signaling 2''' is a [[protein]] that in humans is encoded by the ''SOCS2'' [[gene]].<ref name="pmid9344848">{{cite journal |author1=Masuhara M |author2=Sakamoto H |author3=Matsumoto A |author4=Suzuki R |author5=Yasukawa H |author6=Mitsui K |author7=Wakioka T |author8=Tanimura S |author9=Sasaki A |author10=Misawa H |author11=Yokouchi M |author12=Ohtsubo M |author13=Yoshimura A | title = Cloning and characterization of novel CIS family genes | journal = Biochem Biophys Res Commun | volume = 239 | issue = 2 | pages = 439–46 |date=November 1997 | pmid = 9344848 | pmc = | doi = 10.1006/bbrc.1997.7484 }}</ref><ref name="pmid9266833">{{cite journal |author1=Minamoto S |author2=Ikegame K |author3=Ueno K |author4=Narazaki M |author5=Naka T |author6=Yamamoto H |author7=Matsumoto T |author8=Saito H |author9=Hosoe S |author10=Kishimoto T | title = Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3 | journal = Biochem Biophys Res Commun | volume = 237 | issue = 1 | pages = 79–83 |date=September 1997 | pmid = 9266833 | pmc = | doi = 10.1006/bbrc.1997.7080 }}</ref><ref name="entrez_ 8835">{{cite web | title = Entrez Gene: SOCS2 suppressor of cytokine signaling 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8835| accessdate = }}</ref> | |||
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as [[suppressor of cytokine signalling]] (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including [[erythropoietin]], [[Granulocyte macrophage colony-stimulating factor|GM-CSF]], [[Interleukin 10|IL10]] and [[interferon-gamma]] (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of [[insulin-like growth factor 1 receptor]] (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.<ref name="pmid9727029">{{cite journal |author1=Dey BR |author2=Spence SL |author3=Nissley P |author4=Furlanetto RW | title = Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor | journal = J. Biol. Chem. | volume = 273 | issue = 37 | pages = 24095–101 |date=September 1998 | pmid = 9727029 | doi = 10.1074/jbc.273.37.24095 | url = }}</ref> [[Knockout mouse|Knockout]] studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.<ref name="entrez_ 8835"/><ref name="pmid12040024">{{cite journal |author1=Greenhalgh CJ |author2=Bertolino P |author3=Asa SL |author4=Metcalf D |author5=Corbin JE |author6=Adams TE |author7=Davey HW |author8=Nicola NA |author9=Hilton DJ |author10=Alexander WS | title = Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b) | journal = Mol. Endocrinol. | volume = 16 | issue = 6 | pages = 1394–406 |date=June 2002 | pmid = 12040024 | doi = 10.1210/me.16.6.1394 | url = }}</ref> | |||
==Interactions== | |||
SOCS2 has been shown to [[Protein-protein interaction|interact]] with [[insulin-like growth factor 1 receptor]]<ref name=pmid9727029 /> and [[erythropoietin receptor]].<ref name=pmid11781573>{{cite journal |last=Eyckerman |first=S |authorlink= |author2=Verhee A |author3=der Heyden J V |author4=Lemmens I |author5=Ostade X V |author6=Vandekerckhove J |author7=Tavernier J |date=Dec 2001 |title=Design and application of a cytokine-receptor-based interaction trap |journal=Nat. Cell Biol. |volume=3 |issue=12 |pages=1114–9 |publisher= |location = England| issn = 1465-7392| pmid = 11781573 |doi = 10.1038/ncb1201-1114 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | |||
{{Reflist|2}} | |||
==Further reading== | |||
{{Refbegin | 2}} | |||
{{PBB_Further_reading | |||
| citations = | |||
*{{cite journal | author=Lopaczynski W |title=Differential regulation of signaling pathways for insulin and insulin-like growth factor I. |journal=Acta Biochim. Pol. |volume=46 |issue= 1 |pages= 51–60 |year= 1999 |pmid= 10453981 |doi= }} | |||
*{{cite journal |author1=Wang J |author2=Campbell IL |title=Cytokine signaling in the brain: putting a SOCS in it? |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 423–7 |year= 2002 |pmid= 11835308 |doi=10.1002/jnr.10145 }} | |||
*{{cite journal |vauthors=Kile BT, Schulman BA, Alexander WS, etal |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235–41 |year= 2002 |pmid= 12076535 |doi=10.1016/S0968-0004(02)02085-6 }} | |||
*{{cite journal |author1=Pezet A |author2=Buteau H |author3=Kelly PA |author4=Edery M |title=The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. |journal=Mol. Cell. Endocrinol. |volume=129 |issue= 2 |pages= 199–208 |year= 1997 |pmid= 9202403 |doi=10.1016/S0303-7207(97)00063-4 }} | |||
*{{cite journal |author1=Dey BR |author2=Spence SL |author3=Nissley P |author4=Furlanetto RW |title=Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 24095–101 |year= 1998 |pmid= 9727029 |doi=10.1074/jbc.273.37.24095 }} | |||
*{{cite journal |author1=Pezet A |author2=Favre H |author3=Kelly PA |author4=Edery M |title=Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24497–502 |year= 1999 |pmid= 10455112 |doi=10.1074/jbc.274.35.24497 }} | |||
*{{cite journal |author1=Yandava CN |author2=Pillari A |author3=Drazen JM |title=Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. |journal=Genomics |volume=61 |issue= 1 |pages= 108–11 |year= 1999 |pmid= 10512686 |doi= 10.1006/geno.1999.5937 }} | |||
*{{cite journal |author1=Ram PA |author2=Waxman DJ |title=SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35553–61 |year= 2000 |pmid= 10585430 |doi=10.1074/jbc.274.50.35553 }} | |||
*{{cite journal |vauthors=Metcalf D, Greenhalgh CJ, Viney E, etal |title=Gigantism in mice lacking suppressor of cytokine signalling-2. |journal=Nature |volume=405 |issue= 6790 |pages= 1069–73 |year= 2000 |pmid= 10890450 |doi= 10.1038/35016611 }} | |||
*{{cite journal |author1=Shen X |author2=Hong F |author3=Nguyen VA |author4=Gao B |title=IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. |journal=FEBS Lett. |volume=480 |issue= 2-3 |pages= 132–6 |year= 2000 |pmid= 11034314 |doi=10.1016/S0014-5793(00)01905-0 }} | |||
*{{cite journal |vauthors=Eyckerman S, Verhee A, der Heyden JV, etal |title=Design and application of a cytokine-receptor-based interaction trap. |journal=Nat. Cell Biol. |volume=3 |issue= 12 |pages= 1114–9 |year= 2002 |pmid= 11781573 |doi= 10.1038/ncb1201-1114 }} | |||
*{{cite journal |vauthors=Schultheis B, Carapeti-Marootian M, Hochhaus A, etal |title=Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism. |journal=Blood |volume=99 |issue= 5 |pages= 1766–75 |year= 2002 |pmid= 11861294 |doi=10.1182/blood.V99.5.1766 }} | |||
*{{cite journal |author1=Blumenstein M |author2=Bowen-Shauver JM |author3=Keelan JA |author4=Mitchell MD |title=Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 3 |pages= 1094–7 |year= 2002 |pmid= 11889171 |doi=10.1210/jc.87.3.1094 }} | |||
*{{cite journal |vauthors=Biener E, Maurice S, Sandowski Y, etal |title=Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization. |journal=Protein Expr. Purif. |volume=25 |issue= 2 |pages= 305–12 |year= 2003 |pmid= 12135564 |doi=10.1016/S1046-5928(02)00013-X }} | |||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | |||
}} | |||
{{Refend}} | |||
{{PDB Gallery|geneid=8835}} | |||
==External links== | |||
* {{MeshName|SOCS2+protein,+human}} | |||
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{{JAK-STAT signaling pathway}} | |||
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Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.[1][2][3]
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[4] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[3][5]
Interactions
SOCS2 has been shown to interact with insulin-like growth factor 1 receptor[4] and erythropoietin receptor.[6]
References
- ↑ Masuhara M; Sakamoto H; Matsumoto A; Suzuki R; Yasukawa H; Mitsui K; Wakioka T; Tanimura S; Sasaki A; Misawa H; Yokouchi M; Ohtsubo M; Yoshimura A (November 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
- ↑ Minamoto S; Ikegame K; Ueno K; Narazaki M; Naka T; Yamamoto H; Matsumoto T; Saito H; Hosoe S; Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
- ↑ 3.0 3.1 "Entrez Gene: SOCS2 suppressor of cytokine signaling 2".
- ↑ 4.0 4.1 Dey BR; Spence SL; Nissley P; Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029.
- ↑ Greenhalgh CJ; Bertolino P; Asa SL; Metcalf D; Corbin JE; Adams TE; Davey HW; Nicola NA; Hilton DJ; Alexander WS (June 2002). "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Mol. Endocrinol. 16 (6): 1394–406. doi:10.1210/me.16.6.1394. PMID 12040024.
- ↑ Eyckerman, S; Verhee A; der Heyden J V; Lemmens I; Ostade X V; Vandekerckhove J; Tavernier J (Dec 2001). "Design and application of a cytokine-receptor-based interaction trap". Nat. Cell Biol. England. 3 (12): 1114–9. doi:10.1038/ncb1201-1114. ISSN 1465-7392. PMID 11781573.
Further reading
- Lopaczynski W (1999). "Differential regulation of signaling pathways for insulin and insulin-like growth factor I.". Acta Biochim. Pol. 46 (1): 51–60. PMID 10453981.
- Wang J; Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308.
- Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
- Pezet A; Buteau H; Kelly PA; Edery M (1997). "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor". Mol. Cell. Endocrinol. 129 (2): 199–208. doi:10.1016/S0303-7207(97)00063-4. PMID 9202403.
- Dey BR; Spence SL; Nissley P; Furlanetto RW (1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029.
- Pezet A; Favre H; Kelly PA; Edery M (1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". J. Biol. Chem. 274 (35): 24497–502. doi:10.1074/jbc.274.35.24497. PMID 10455112.
- Yandava CN; Pillari A; Drazen JM (1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively". Genomics. 61 (1): 108–11. doi:10.1006/geno.1999.5937. PMID 10512686.
- Ram PA; Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". J. Biol. Chem. 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430.
- Metcalf D, Greenhalgh CJ, Viney E, et al. (2000). "Gigantism in mice lacking suppressor of cytokine signalling-2". Nature. 405 (6790): 1069–73. doi:10.1038/35016611. PMID 10890450.
- Shen X; Hong F; Nguyen VA; Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3". FEBS Lett. 480 (2–3): 132–6. doi:10.1016/S0014-5793(00)01905-0. PMID 11034314.
- Eyckerman S, Verhee A, der Heyden JV, et al. (2002). "Design and application of a cytokine-receptor-based interaction trap". Nat. Cell Biol. 3 (12): 1114–9. doi:10.1038/ncb1201-1114. PMID 11781573.
- Schultheis B, Carapeti-Marootian M, Hochhaus A, et al. (2002). "Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism". Blood. 99 (5): 1766–75. doi:10.1182/blood.V99.5.1766. PMID 11861294.
- Blumenstein M; Bowen-Shauver JM; Keelan JA; Mitchell MD (2002). "Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor". J. Clin. Endocrinol. Metab. 87 (3): 1094–7. doi:10.1210/jc.87.3.1094. PMID 11889171.
- Biener E, Maurice S, Sandowski Y, et al. (2003). "Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization". Protein Expr. Purif. 25 (2): 305–12. doi:10.1016/S1046-5928(02)00013-X. PMID 12135564.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
External links
- SOCS2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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