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{{for|the French airline in operation from 1919-33|Société Générale des Transports Aériens}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Small glutamine-rich tetratricopeptide repeat-containing protein alpha''' is a [[protein]] that in humans is encoded by the ''SGTA'' [[gene]].<ref name="pmid9740675">{{cite journal | vauthors = Kordes E, Savelyeva L, Schwab M, Rommelaere J, Jauniaux JC, Cziepluch C | title = Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans | journal = Genomics | volume = 52 | issue = 1 | pages = 90–4 | date = Aug 1998 | pmid = 9740675 | pmc =  | doi = 10.1006/geno.1998.5385 }}</ref><ref name="pmid12735788">{{cite journal | vauthors = Schantl JA, Roza M, De Jong AP, Strous GJ | title = Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor | journal = The Biochemical Journal | volume = 373 | issue = Pt 3 | pages = 855–63 | date = Aug 2003 | pmid = 12735788 | pmc = 1223544 | doi = 10.1042/BJ20021591 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6449| accessdate = }}</ref> ''SGTA'' [[orthologs]] <ref name="OrthoMaM">{{cite web | title = OrthoMaM phylogenetic marker: SGTA coding sequence | url = http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000104969_SGTA.xml }}</ref> have also been identified in several [[mammals]] for which complete genome data are available.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
| HGNCid = 10819
| Symbol = SGTA
| AltSymbols =; SGT; hSGT
| OMIM = 603419
| ECnumber = 
| Homologene = 31122
| MGIid = 1098703
| GeneAtlas_image1 = PBB_GE_SGTA_201396_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6449
    | Hs_Ensembl = ENSG00000104969
    | Hs_RefseqProtein = NP_003012
    | Hs_RefseqmRNA = NM_003021
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 2705712
    | Hs_GenLoc_end = 2734354
    | Hs_Uniprot = O43765
    | Mm_EntrezGene = 52551
    | Mm_Ensembl = ENSMUSG00000004937
    | Mm_RefseqmRNA = NM_024499
    | Mm_RefseqProtein = NP_078775
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80447204
    | Mm_GenLoc_end = 80463291
    | Mm_Uniprot = Q3TN35
  }}
}}
'''Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha''', also known as '''SGTA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6449| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.<ref name="entrez">{{cite web | title = Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6449| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SGTA has been shown to [[Protein-protein interaction|interact]] with [[Growth hormone receptor]].<ref name="pmid12735788"/>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Roberts JD, Thapaliya A, Martínez-Lumbreras S, Krysztofinska EM, Isaacson RL | title = Structural and Functional Insights into Small, Glutamine-Rich, Tetratricopeptide Repeat Protein Alpha | journal = Frontiers in Molecular Biosciences | volume = 2 | date = Dec 2015 | pmid = 26734616 | doi = 10.3389/fmolb.2015.00071 |url = http://journal.frontiersin.org/article/10.3389/fmolb.2015.00071/abstract | pmc=4683186 | pages=71}}
| citations =  
* {{cite journal | vauthors = Heavner GA, Audhya T, Goldstein G | title = Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines | journal = Regulatory Peptides | volume = 27 | issue = 2 | pages = 257–62 | date = Feb 1990 | pmid = 2158125 | doi = 10.1016/0167-0115(90)90044-W }}{{cite journal | vauthors = Geraghty RJ, Talbot KJ, Callahan M, Harper W, Panganiban AT | title = Cell type-dependence for Vpu function | journal = Journal of Medical Primatology | volume = 23 | issue = 2–3 | pages = 146–50 | year = 1994 | pmid = 7966229 | doi = 10.1111/j.1600-0684.1994.tb00115.x }}
*{{cite journal | author=Heavner GA, Audhya T, Goldstein G |title=Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines. |journal=Regul. Pept. |volume=27 |issue= 2 |pages= 257-62 |year= 1990 |pmid= 2158125 |doi= }}
* {{cite journal | vauthors = Cziepluch C, Kordes E, Poirey R, Grewenig A, Rommelaere J, Jauniaux JC | title = Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1 | journal = Journal of Virology | volume = 72 | issue = 5 | pages = 4149–56 | date = May 1998 | pmid = 9557704 | pmc = 109644 | doi =  }}
*{{cite journal | author=Geraghty RJ, Talbot KJ, Callahan M, ''et al.'' |title=Cell type-dependence for Vpu function. |journal=J. Med. Primatol. |volume=23 |issue= 2-3 |pages= 146-50 |year= 1994 |pmid= 7966229 |doi= }}
* {{cite journal | vauthors = Callahan MA, Handley MA, Lee YH, Talbot KJ, Harper JW, Panganiban AT | title = Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family | journal = Journal of Virology | volume = 72 | issue = 6 | pages = 5189–97 | date = Jun 1998 | pmid = 9573291 | pmc = 110095 | doi = }}
*{{cite journal | author=Cziepluch C, Kordes E, Poirey R, ''et al.'' |title=Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1. |journal=J. Virol. |volume=72 |issue= 5 |pages= 4149-56 |year= 1998 |pmid= 9557704 |doi=  }}
* {{cite journal | vauthors = Callahan MA, Handley MA, Lee YH, Talbot KJ, Harper JW, Panganiban AT | title = Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family | journal = Journal of Virology | volume = 72 | issue = 10 | pages = 8461 | date = Oct 1998 | pmid = 9766974 | doi =  }}
*{{cite journal | author=Callahan MA, Handley MA, Lee YH, ''et al.'' |title=Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family. |journal=J. Virol. |volume=72 |issue= 6 |pages= 5189-97 |year= 1998 |pmid= 9573291 |doi= }}
* {{cite journal | vauthors = Liu FH, Wu SJ, Hu SM, Hsiao CD, Wang C | title = Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats | journal = The Journal of Biological Chemistry | volume = 274 | issue = 48 | pages = 34425–32 | date = Nov 1999 | pmid = 10567422 | doi = 10.1074/jbc.274.48.34425 }}
*{{cite journal  | author=Kordes E, Savelyeva L, Schwab M, ''et al.'' |title=Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. |journal=Genomics |volume=52 |issue= 1 |pages= 90-4 |year= 1999 |pmid= 9740675 |doi= 10.1006/geno.1998.5385 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Callahan MA, Handley MA, Lee YH, ''et al.'' |title=Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family. |journal=J. Virol. |volume=72 |issue= 10 |pages= 8461 |year= 1998 |pmid= 9766974 |doi=  }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Liu FH, Wu SJ, Hu SM, ''et al.'' |title=Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats. |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 34425-32 |year= 1999 |pmid= 10567422 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Handley MA, Paddock S, Dall A, Panganiban AT | title = Association of Vpu-binding protein with microtubules and Vpu-dependent redistribution of HIV-1 Gag protein | journal = Virology | volume = 291 | issue = 2 | pages = 198–207 | date = Dec 2001 | pmid = 11878889 | doi = 10.1006/viro.2001.1166 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Angeletti PC, Walker D, Panganiban AT | title = Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity | journal = Cell Stress & Chaperones | volume = 7 | issue = 3 | pages = 258–68 | date = Jul 2002 | pmid = 12482202 | pmc = 514826 | doi = 10.1379/1466-1268(2002)007<0258:SGRPVP>2.0.CO;2 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Pai MT, Yang CS, Tzeng SR, Wang C, Cheng JW | title = 1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT | journal = Journal of Biomolecular NMR | volume = 26 | issue = 4 | pages = 381–2 | date = Aug 2003 | pmid = 12815268 | doi = 10.1023/A:1024029117511 }}
*{{cite journal | author=Handley MA, Paddock S, Dall A, Panganiban AT |title=Association of Vpu-binding protein with microtubules and Vpu-dependent redistribution of HIV-1 Gag protein. |journal=Virology |volume=291 |issue= 2 |pages= 198-207 |year= 2002 |pmid= 11878889 |doi= 10.1006/viro.2001.1166 }}
* {{cite journal | vauthors = Wang H, Zhang Q, Zhu D | title = hSGT interacts with the N-terminal region of myostatin | journal = Biochemical and Biophysical Research Communications | volume = 311 | issue = 4 | pages = 877–83 | date = Nov 2003 | pmid = 14623262 | doi = 10.1016/j.bbrc.2003.10.080 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | date = Jan 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }}
*{{cite journal  | author=Angeletti PC, Walker D, Panganiban AT |title=Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity. |journal=Cell Stress Chaperones |volume=7 |issue= 3 |pages= 258-68 |year= 2003 |pmid= 12482202 |doi= }}
* {{cite journal | vauthors = Winnefeld M, Rommelaere J, Cziepluch C | title = The human small glutamine-rich TPR-containing protein is required for progress through cell division | journal = Experimental Cell Research | volume = 293 | issue = 1 | pages = 43–57 | date = Feb 2004 | pmid = 14729056 | doi = 10.1016/j.yexcr.2003.09.028 }}
*{{cite journal  | author=Schantl JA, Roza M, De Jong AP, Strous GJ |title=Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 855-63 |year= 2003 |pmid= 12735788 |doi= 10.1042/BJ20021591 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Pai MT, Yang CS, Tzeng SR, ''et al.'' |title=1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT. |journal=J. Biomol. NMR |volume=26 |issue= 4 |pages= 381-2 |year= 2004 |pmid= 12815268 |doi= }}
*{{cite journal | author=Wang H, Zhang Q, Zhu D |title=hSGT interacts with the N-terminal region of myostatin. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 4 |pages= 877-83 |year= 2004 |pmid= 14623262 |doi= }}
*{{cite journal | author=Lehner B, Semple JI, Brown SE, ''et al.'' |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. |journal=Genomics |volume=83 |issue= 1 |pages= 153-67 |year= 2004 |pmid= 14667819 |doi= }}
*{{cite journal | author=Winnefeld M, Rommelaere J, Cziepluch C |title=The human small glutamine-rich TPR-containing protein is required for progress through cell division. |journal=Exp. Cell Res. |volume=293 |issue= 1 |pages= 43-57 |year= 2004 |pmid= 14729056 |doi= }}
*{{cite journal  | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-19-stub}}
 
[[Category:Co-chaperones]]

Latest revision as of 15:38, 18 October 2018

For the French airline in operation from 1919-33, see Société Générale des Transports Aériens.
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.[1][2][3] SGTA orthologs [4] have also been identified in several mammals for which complete genome data are available.

Function

This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.[3]

Interactions

SGTA has been shown to interact with Growth hormone receptor.[2]

References

  1. ↑ Kordes E, Savelyeva L, Schwab M, Rommelaere J, Jauniaux JC, Cziepluch C (Aug 1998). "Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans". Genomics. 52 (1): 90–4. doi:10.1006/geno.1998.5385. PMID 9740675.
  2. ↑ 2.0 2.1 Schantl JA, Roza M, De Jong AP, Strous GJ (Aug 2003). "Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor". The Biochemical Journal. 373 (Pt 3): 855–63. doi:10.1042/BJ20021591. PMC 1223544. PMID 12735788.
  3. ↑ 3.0 3.1 "Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha".
  4. ↑ "OrthoMaM phylogenetic marker: SGTA coding sequence".

Further reading


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