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imported>Neo-Jay
(for other uses, see Spen (disambiguation) (redirecting disambiguation page Spen, which I just changed from redirecting River Spen))
 
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{{Other uses|Spen (disambiguation)}}
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{{Infobox_gene}}
| update_page = yes
'''Msx2-interacting protein''' is a [[protein]] that in humans is encoded by the ''SPEN'' [[gene]].<ref name="pmid10451362">{{cite journal | vauthors = Newberry EP, Latifi T, Towler DA | title = The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter | journal = Biochemistry | volume = 38 | issue = 33 | pages = 10678–90 |date=Sep 1999 | pmid = 10451362 | pmc =  | doi = 10.1021/bi990967j }}</ref><ref name="pmid11331609">{{cite journal | vauthors = Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM | title = Sharp, an inducible cofactor that integrates nuclear receptor repression and activation | journal = Genes Dev | volume = 15 | issue = 9 | pages = 1140–51 |date=May 2001 | pmid = 11331609 | pmc = 312688 | doi = 10.1101/gad.871201 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23013| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SPEN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ow1.
| PDB = {{PDB2|1ow1}}
| Name = Spen homolog, transcriptional regulator (Drosophila)
| HGNCid = 17575
| Symbol = SPEN
| AltSymbols =; KIAA0929; MINT; RP1-134O19.1; SHARP
| OMIM = 
| ECnumber = 
| Homologene = 8992
| MGIid = 1891706
| GeneAtlas_image1 = PBB_GE_SPEN_201997_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
  | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23013
    | Hs_Ensembl = ENSG00000065526
    | Hs_RefseqProtein = NP_055816
    | Hs_RefseqmRNA = NM_015001
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 16046946
    | Hs_GenLoc_end = 16139542
    | Hs_Uniprot = Q96T58
    | Mm_EntrezGene = 56381
    | Mm_Ensembl = ENSMUSG00000040761
    | Mm_RefseqmRNA = NM_019763
    | Mm_RefseqProtein = NP_062737
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 140740934
    | Mm_GenLoc_end = 140810322
    | Mm_Uniprot = Q62504
  }}
}}
'''Spen homolog, transcriptional regulator (Drosophila)''', also known as '''SPEN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23013| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.<ref name="entrez">{{cite web | title = Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23013| accessdate = }}</ref>
| summary_text = This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.<ref name="entrez">{{cite web | title = Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23013| accessdate = }}</ref>
}}
}}
==Interactions==
SPEN has been shown to [[Protein-protein interaction|interact]] with [[HDAC1]],<ref name=pmid11331609 /> [[SRA1]]<ref name=pmid11331609/> and [[Nuclear receptor co-repressor 2]].<ref name=pmid11331609/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ternovskaia LN, Prokhorova LG, Moroz VM |title=[Antagonistic interrelationships between the staphylococci and Sarcina isolated from the upper respiratory tracts of virtually healthy persons] |journal=Antibiotiki |volume=21 |issue= 12 |pages= 1072-5 |year= 1977 |pmid= 1020939 |doi=  }}
*{{cite journal  | vauthors=Ternovskaia LN, Prokhorova LG, Moroz VM |title=[Antagonistic interrelationships between the staphylococci and Sarcina isolated from the upper respiratory tracts of virtually healthy persons] |journal=Antibiotiki |volume=21 |issue= 12 |pages= 1072–5 |year= 1977 |pmid= 1020939 |doi=  }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63-70 |year= 1999 |pmid= 10231032 |doi=  }}
*{{cite journal   |vauthors=Nagase T, Ishikawa K, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 1 |pages= 63–70 |year= 1999 |pmid= 10231032 |doi=10.1093/dnares/6.1.63  }}
*{{cite journal  | author=Newberry EP, Latifi T, Towler DA |title=The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter. |journal=Biochemistry |volume=38 |issue= 33 |pages= 10678-90 |year= 1999 |pmid= 10451362 |doi= 10.1021/bi990967j }}
*{{cite journal  | vauthors=Shi Y, Hon M, Evans RM |title=The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2613–8 |year= 2002 |pmid= 11867749 |doi= 10.1073/pnas.052707099 | pmc=122396 }}
*{{cite journal  | author=Shi Y, Downes M, Xie W, ''et al.'' |title=Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. |journal=Genes Dev. |volume=15 |issue= 9 |pages= 1140-51 |year= 2001 |pmid= 11331609 |doi= 10.1101/gad.871201 }}
*{{cite journal   |vauthors=Oswald F, Kostezka U, Astrahantseff K, etal |title=SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. |journal=EMBO J. |volume=21 |issue= 20 |pages= 5417–26 |year= 2002 |pmid= 12374742 |doi=10.1093/emboj/cdf549  | pmc=129081 }}
*{{cite journal  | author=Shi Y, Hon M, Evans RM |title=The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2613-8 |year= 2002 |pmid= 11867749 |doi= 10.1073/pnas.052707099 }}
*{{cite journal  | vauthors=Ariyoshi M, Schwabe JW |title=A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. |journal=Genes Dev. |volume=17 |issue= 15 |pages= 1909–20 |year= 2003 |pmid= 12897056 |doi= 10.1101/gad.266203 | pmc=196244 }}
*{{cite journal | author=Oswald F, Kostezka U, Astrahantseff K, ''et al.'' |title=SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. |journal=EMBO J. |volume=21 |issue= 20 |pages= 5417-26 |year= 2002 |pmid= 12374742 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ariyoshi M, Schwabe JW |title=A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. |journal=Genes Dev. |volume=17 |issue= 15 |pages= 1909-20 |year= 2003 |pmid= 12897056 |doi= 10.1101/gad.266203 }}
*{{cite journal   |vauthors=Dotzlaw H, Papaioannou M, Moehren U, etal |title=Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor. |journal=Mol. Cell. Endocrinol. |volume=213 |issue= 1 |pages= 79–85 |year= 2004 |pmid= 15062576 |doi= 10.1016/j.mce.2003.10.036 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Dotzlaw H, Papaioannou M, Moehren U, ''et al.'' |title=Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor. |journal=Mol. Cell. Endocrinol. |volume=213 |issue= 1 |pages= 79-85 |year= 2004 |pmid= 15062576 |doi= 10.1016/j.mce.2003.10.036 }}
*{{cite journal   |vauthors=Vadlamudi RK, Manavathi B, Singh RR, etal |title=An essential role of Pak1 phosphorylation of SHARP in Notch signaling. |journal=Oncogene |volume=24 |issue= 28 |pages= 4591–6 |year= 2005 |pmid= 15824732 |doi= 10.1038/sj.onc.1208672 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Li J, Wang J, Yang X, etal |title=The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8. |journal=Mol. Cell. Biochem. |volume=288 |issue= 1-2 |pages= 151–7 |year= 2007 |pmid= 16583136 |doi= 10.1007/s11010-006-9131-9 }}
*{{cite journal | author=Vadlamudi RK, Manavathi B, Singh RR, ''et al.'' |title=An essential role of Pak1 phosphorylation of SHARP in Notch signaling. |journal=Oncogene |volume=24 |issue= 28 |pages= 4591-6 |year= 2005 |pmid= 15824732 |doi= 10.1038/sj.onc.1208672 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Li J, Wang J, Yang X, ''et al.'' |title=The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8. |journal=Mol. Cell. Biochem. |volume=288 |issue= 1-2 |pages= 151-7 |year= 2007 |pmid= 16583136 |doi= 10.1007/s11010-006-9131-9 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal   |vauthors=Feng Y, Bommer GT, Zhai Y, etal |title=Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. |journal=Cancer Res. |volume=67 |issue= 2 |pages= 482–91 |year= 2007 |pmid= 17234755 |doi= 10.1158/0008-5472.CAN-06-2314 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Feng Y, Bommer GT, Zhai Y, ''et al.'' |title=Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation. |journal=Cancer Res. |volume=67 |issue= 2 |pages= 482-91 |year= 2007 |pmid= 17234755 |doi= 10.1158/0008-5472.CAN-06-2314 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=23013}}
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Latest revision as of 06:17, 11 August 2018

For other uses, see Spen (disambiguation).
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.[1][2][3]

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.[3]

Interactions

SPEN has been shown to interact with HDAC1,[2] SRA1[2] and Nuclear receptor co-repressor 2.[2]

References

  1. ↑ Newberry EP, Latifi T, Towler DA (Sep 1999). "The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter". Biochemistry. 38 (33): 10678–90. doi:10.1021/bi990967j. PMID 10451362.
  2. ↑ 2.0 2.1 2.2 2.3 Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes Dev. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
  3. ↑ 3.0 3.1 "Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)".

Further reading



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