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{{Infobox_gene}}
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'''Olfactory receptor 2T11''' is a [[protein]] that in humans is encoded by the ''OR2T11'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127077| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Olfactory receptor, family 2, subfamily T, member 11
| HGNCid = 19574
| Symbol = OR2T11
| AltSymbols =; OR2T11Q
| OMIM = 
| ECnumber = 
| Homologene = 84585
| MGIid = 
| GeneAtlas_image1 = PBB_GE_OR2T11_gnf1h10951_at_tn.png
| GeneAtlas_image2 = PBB_GE_OR2T11_gnf1h10952_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_OR2T11_gnf1h10953_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 127077
    | Hs_Ensembl = ENSG00000183130
    | Hs_RefseqProtein = NP_001001964
    | Hs_RefseqmRNA = NM_001001964
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 246856102
    | Hs_GenLoc_end = 246857052
    | Hs_Uniprot = Q8NH01
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 2, subfamily T, member 11''', also known as '''OR2T11''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127077| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127077| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=127077| accessdate = }}</ref>
}}
}}
==Ligands==
* [[tert-Butylthiol]] (the response is enhanced by the presence of ionic [[copper]])<ref name=Li>{{cite journal |author=Li, S.|title=Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols|journal=[[J. Am. Chem. Soc.]] |volume=138|issue=40| pages=13281–13288|year=2018|doi=10.1021/jacs.6b06983|pmid=27659093|display-authors=etal}}</ref>
* [[Ethanethiol]] (the response is enhanced by the presence of ionic [[copper]])<ref name=Li/>
* 2-Propenethiol ([[allyl mercaptan]]) (the response is enhanced by the presence of ionic [[copper]])<ref name=Li/>
* [[Thietane]] (the response is enhanced by the presence of ionic [[copper]])<ref name=Li/>


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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[[Category:Olfactory receptors]]

Latest revision as of 06:55, 26 November 2018

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External IDsGeneCards: [1]
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SpeciesHumanMouse
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Wikidata
View/Edit Human

Olfactory receptor 2T11 is a protein that in humans is encoded by the OR2T11 gene.[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

Ligands

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: OR2T11 olfactory receptor, family 2, subfamily T, member 11".
  2. ↑ 2.0 2.1 2.2 2.3 Li, S.; et al. (2018). "Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols". J. Am. Chem. Soc. 138 (40): 13281–13288. doi:10.1021/jacs.6b06983. PMID 27659093.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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