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'''Pre-mRNA-processing factor 40 homolog A''' is a [[protein]] that in humans is encoded by the ''PRPF40A'' [[gene]].<ref name="pmid9724750">{{cite journal |vauthors=Bedford MT, Reed R, Leder P | title = WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 18 | pages = 10602–7 |date=Sep 1998 | pmid = 9724750 | pmc = 27941 | doi =10.1073/pnas.95.18.10602  | bibcode =1998PNAS...9510602B }}</ref><ref name="pmid12460579">{{cite journal |vauthors=Wiesner S, Stier G, Sattler M, Macias MJ | title = Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40 | journal = J Mol Biol | volume = 324 | issue = 4 | pages = 807–22 |date=Dec 2002 | pmid = 12460579 | pmc =  | doi =10.1016/S0022-2836(02)01145-2  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55660| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PRPF40A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1uzc.
| PDB = {{PDB2|1uzc}}, {{PDB2|1ywi}}, {{PDB2|1ywj}}, {{PDB2|1zr7}}, {{PDB2|2cqn}}, {{PDB2|2dyf}}
| Name = PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
| HGNCid = 16463
| Symbol = PRPF40A
| AltSymbols =; FBP-11; FBP11; FLAF1; FLJ20585; FNBP3; HIP10; HYPA; NY-REN-6
| OMIM = 
| ECnumber = 
| Homologene = 6377
| MGIid = 1860512
| GeneAtlas_image1 = PBB_GE_PRPF40A_213729_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRPF40A_214941_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRPF40A_218053_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55660
    | Hs_Ensembl = ENSG00000196504
    | Hs_RefseqProtein = XP_371575
    | Hs_RefseqmRNA = XM_371575
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 153221066
    | Hs_GenLoc_end = 153282206
    | Hs_Uniprot = O75400
    | Mm_EntrezGene = 56194
    | Mm_Ensembl = ENSMUSG00000061136
    | Mm_RefseqmRNA = NM_018785
    | Mm_RefseqProtein = NP_061255
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 52956713
    | Mm_GenLoc_end = 53013234
    | Mm_Uniprot = A0PJI0
  }}
}}
'''PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)''', also known as '''PRPF40A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55660| accessdate = }}</ref>
 
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==Interactions==
PRPF40A has been shown to [[Protein-protein interaction|interact]] with [[Huntingtin]].<ref name=pmid9700202>{{cite journal |last=Faber |first=P W |authorlink= |author2=Barnes G T |author3=Srinidhi J |author4=Chen J |author5=Gusella J F |author6=MacDonald M E  |date=Sep 1998 |title=Huntingtin interacts with a family of WW domain proteins |journal=Hum. Mol. Genet. |volume=7 |issue=9 |pages=1463–74 |publisher= |location = ENGLAND| issn = 0964-6906| pmid = 9700202 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/hmg/7.9.1463 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Chan DC, Bedford MT, Leder P |title=Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1045-54 |year= 1996 |pmid= 8605874 |doi=  }}
*{{cite journal  |vauthors=Chan DC, Bedford MT, Leder P |title=Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1045–54 |year= 1996 |pmid= 8605874 |doi= | pmc=450002 }}
*{{cite journal  | author=Bedford MT, Chan DC, Leder P |title=FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. |journal=EMBO J. |volume=16 |issue= 9 |pages= 2376-83 |year= 1997 |pmid= 9171351 |doi= 10.1093/emboj/16.9.2376 }}
*{{cite journal  |vauthors=Bedford MT, Chan DC, Leder P |title=FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. |journal=EMBO J. |volume=16 |issue= 9 |pages= 2376–83 |year= 1997 |pmid= 9171351 |doi= 10.1093/emboj/16.9.2376 | pmc=1169838 }}
*{{cite journal | author=Faber PW, Barnes GT, Srinidhi J, ''et al.'' |title=Huntingtin interacts with a family of WW domain proteins. |journal=Hum. Mol. Genet. |volume=7 |issue= 9 |pages= 1463-74 |year= 1998 |pmid= 9700202 |doi= }}
*{{cite journal   |vauthors=Faber PW, Barnes GT, Srinidhi J, etal |title=Huntingtin interacts with a family of WW domain proteins. |journal=Hum. Mol. Genet. |volume=7 |issue= 9 |pages= 1463–74 |year= 1998 |pmid= 9700202 |doi=10.1093/hmg/7.9.1463  }}
*{{cite journal | author=Bedford MT, Reed R, Leder P |title=WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10602-7 |year= 1998 |pmid= 9724750 |doi= }}
*{{cite journal   |vauthors=Scanlan MJ, Gordan JD, Williamson B, etal |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456–64 |year= 1999 |pmid= 10508479 |doi=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5  }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi= }}
*{{cite journal   |vauthors=Bedford MT, Sarbassova D, Xu J, etal |title=A novel pro-Arg motif recognized by WW domains. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10359–69 |year= 2000 |pmid= 10744724 |doi=10.1074/jbc.275.14.10359  }}
*{{cite journal | author=Bedford MT, Sarbassova D, Xu J, ''et al.'' |title=A novel pro-Arg motif recognized by WW domains. |journal=J. Biol. Chem. |volume=275 |issue= 14 |pages= 10359-69 |year= 2000 |pmid= 10744724 |doi=  }}
*{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934 }}
*{{cite journal | author=Zhang QH, Ye M, Wu XY, ''et al.'' |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546-60 |year= 2001 |pmid= 11042152 |doi=  }}
*{{cite journal   |vauthors=Wenzel J, Sanzenbacher R, Ghadimi M, etal |title=Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. |journal=FEBS Lett. |volume=509 |issue= 2 |pages= 255–62 |year= 2002 |pmid= 11741599 |doi=10.1016/S0014-5793(01)03174-X }}
*{{cite journal  | author=Wenzel J, Sanzenbacher R, Ghadimi M, ''et al.'' |title=Multiple interactions of the cytosolic polyproline region of the CD95 ligand: hints for the reverse signal transduction capacity of a death factor. |journal=FEBS Lett. |volume=509 |issue= 2 |pages= 255-62 |year= 2002 |pmid= 11741599 |doi=  }}
*{{cite journal  |vauthors=Allen M, Friedler A, Schon O, Bycroft M |title=The structure of an FF domain from human HYPA/FBP11. |journal=J. Mol. Biol. |volume=323 |issue= 3 |pages= 411–6 |year= 2002 |pmid= 12381297 |doi=10.1016/S0022-2836(02)00968-3 }}
*{{cite journal | author=Allen M, Friedler A, Schon O, Bycroft M |title=The structure of an FF domain from human HYPA/FBP11. |journal=J. Mol. Biol. |volume=323 |issue= 3 |pages= 411-6 |year= 2002 |pmid= 12381297 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Wiesner S, Stier G, Sattler M, Macias MJ |title=Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40. |journal=J. Mol. Biol. |volume=324 |issue= 4 |pages= 807-22 |year= 2003 |pmid= 12460579 |doi=  }}
*{{cite journal  |vauthors=Katoh M, Katoh M |title=Identification and characterization of human FNBP3 gene in silico. |journal=Int. J. Mol. Med. |volume=12 |issue= 4 |pages= 651–6 |year= 2004 |pmid= 12964049 |doi=  10.3892/ijmm.12.4.651}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Busino L, Donzelli M, Chiesa M, etal |title=Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. |journal=Nature |volume=426 |issue= 6962 |pages= 87–91 |year= 2003 |pmid= 14603323 |doi= 10.1038/nature02082 |bibcode=2003Natur.426...87B }}
*{{cite journal  | author=Katoh M, Katoh M |title=Identification and characterization of human FNBP3 gene in silico. |journal=Int. J. Mol. Med. |volume=12 |issue= 4 |pages= 651-6 |year= 2004 |pmid= 12964049 |doi=  }}
*{{cite journal  |vauthors=Mizutani K, Suetsugu S, Takenawa T |title=FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 468–74 |year= 2004 |pmid= 14697212 |doi=10.1016/j.bbrc.2003.11.139 }}
*{{cite journal | author=Busino L, Donzelli M, Chiesa M, ''et al.'' |title=Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. |journal=Nature |volume=426 |issue= 6962 |pages= 87-91 |year= 2003 |pmid= 14603323 |doi= 10.1038/nature02082 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Mizutani K, Suetsugu S, Takenawa T |title=FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 468-74 |year= 2004 |pmid= 14697212 |doi=  }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Goehler H, Lalowski M, Stelzl U, etal |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853–65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal  |vauthors=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004  | pmc=517884 }}
*{{cite journal | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176-85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=55660}}
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{{Post transcriptional modification}}


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Latest revision as of 19:52, 25 June 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Pre-mRNA-processing factor 40 homolog A is a protein that in humans is encoded by the PRPF40A gene.[1][2][3]


Interactions

PRPF40A has been shown to interact with Huntingtin.[4]

References

  1. ↑ Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A. 95 (18): 10602–7. Bibcode:1998PNAS...9510602B. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750.
  2. ↑ Wiesner S, Stier G, Sattler M, Macias MJ (Dec 2002). "Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40". J Mol Biol. 324 (4): 807–22. doi:10.1016/S0022-2836(02)01145-2. PMID 12460579.
  3. ↑ "Entrez Gene: PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)".
  4. ↑ Faber, P W; Barnes G T; Srinidhi J; Chen J; Gusella J F; MacDonald M E (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. ENGLAND. 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. ISSN 0964-6906. PMID 9700202.

Further reading



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