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{{Infobox_gene}}
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'''Cdc42 effector protein 3''' is a [[protein]] that in humans is encoded by the ''CDC42EP3'' [[gene]].<ref name="pmid9535835">{{cite journal | vauthors = Alberts AS, Bouquin N, Johnston LH, Treisman R | title = Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7 | journal = J Biol Chem | volume = 273 | issue = 15 | pages = 8616–22 |date=May 1998 | pmid = 9535835 | pmc =  | doi =10.1074/jbc.273.15.8616 }}</ref><ref name="pmid11035016">{{cite journal | vauthors = Hirsch DS, Pirone DM, Burbelo PD | title = A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes | journal = J Biol Chem | volume = 276 | issue = 2 | pages = 875–83 |date=Mar 2001 | pmid = 11035016 | pmc =  | doi = 10.1074/jbc.M007039200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10602| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CDC42 effector protein (Rho GTPase binding) 3
| HGNCid = 16943
| Symbol = CDC42EP3
| AltSymbols =; BORG2; CEP3; FLJ46903; UB1
| OMIM = 606133
| ECnumber =
| Homologene = 4708
| MGIid = 2384718
  | GeneAtlas_image1 = PBB_GE_CDC42EP3_209288_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDC42EP3_209286_at_tn.png
| GeneAtlas_image3 = PBB_GE_CDC42EP3_209287_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005519 |text = cytoskeletal regulatory protein binding}}
| Component = {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10602
    | Hs_Ensembl = ENSG00000163171
    | Hs_RefseqProtein = NP_006440
    | Hs_RefseqmRNA = NM_006449
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 37724247
    | Hs_GenLoc_end = 37752830
    | Hs_Uniprot = Q9UKI2
    | Mm_EntrezGene = 260409
    | Mm_Ensembl = ENSMUSG00000036533
    | Mm_RefseqmRNA = NM_026514
    | Mm_RefseqProtein = NP_080790
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 79238785
    | Mm_GenLoc_end = 79259937
    | Mm_Uniprot = Q9CQC5
  }}
}}
'''CDC42 effector protein (Rho GTPase binding) 3''', also known as '''CDC42EP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10602| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.<ref name="entrez">{{cite web | title = Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10602| accessdate = }}</ref>
| summary_text = CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.<ref name="entrez" />
}}
}}
==Interactions==
CDC42EP3 has been shown to [[Protein-protein interaction|interact]] with [[CDC42]]<ref name=pmid9535835 /><ref name=pmid10490598>{{cite journal |last=Joberty |first=G |author2=Perlungher R R|author3=Macara I G |date=Oct 1999 |title=The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins |journal=Mol. Cell. Biol. |volume=19 |issue=10 |pages=6585–97 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 10490598 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=84628 }}</ref> and [[RHOQ]].<ref name=pmid10490598/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CDC42EP3}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Alberts AS, Bouquin N, Johnston LH, Treisman R |title=Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8616-22 |year= 1998 |pmid= 9535835 |doi=  }}
*{{cite journal  | vauthors=Joberty G, Perlungher RR, Macara IG |title=The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6585–97 |year= 2000 |pmid= 10490598 |doi=  | pmc=84628  }}
*{{cite journal  | author=Joberty G, Perlungher RR, Macara IG |title=The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6585-97 |year= 2000 |pmid= 10490598 |doi= }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal | author=Hirsch DS, Pirone DM, Burbelo PD |title=A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 875-83 |year= 2001 |pmid= 11035016 |doi= 10.1074/jbc.M007039200 }}
*{{cite journal  | vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 |display-authors=etal}}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | vauthors=Simpson JC, Wellenreuther R, Poustka A |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | vauthors=Joberty G, Perlungher RR, Sheffield PJ |title=Borg proteins control septin organization and are negatively regulated by Cdc42 |journal=Nat. Cell Biol. |volume=3 |issue= 10 |pages= 861–6 |year= 2001 |pmid= 11584266 |doi= 10.1038/ncb1001-861 |display-authors=etal}}
*{{cite journal  | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Joberty G, Perlungher RR, Sheffield PJ, ''et al.'' |title=Borg proteins control septin organization and are negatively regulated by Cdc42. |journal=Nat. Cell Biol. |volume=3 |issue= 10 |pages= 861-6 |year= 2001 |pmid= 11584266 |doi= 10.1038/ncb1001-861 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ballif BA, Villén J, Beausoleil SA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to biology: a functional genomics pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4 |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal|bibcode=2005Natur.434..724H }}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | vauthors=Stelzl U, Worm U, Lalowski M |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 01:08, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.[1][2][3]

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.[3]

Interactions

CDC42EP3 has been shown to interact with CDC42[1][4] and RHOQ.[4]

References

  1. ↑ 1.0 1.1 Alberts AS, Bouquin N, Johnston LH, Treisman R (May 1998). "Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7". J Biol Chem. 273 (15): 8616–22. doi:10.1074/jbc.273.15.8616. PMID 9535835.
  2. ↑ Hirsch DS, Pirone DM, Burbelo PD (Mar 2001). "A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes". J Biol Chem. 276 (2): 875–83. doi:10.1074/jbc.M007039200. PMID 11035016.
  3. ↑ 3.0 3.1 "Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3".
  4. ↑ 4.0 4.1 Joberty, G; Perlungher R R; Macara I G (Oct 1999). "The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins". Mol. Cell. Biol. UNITED STATES. 19 (10): 6585–97. ISSN 0270-7306. PMC 84628. PMID 10490598.

External links

Further reading



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