'''Disintegrin and metalloproteinase domain-containing protein 23''' is an [[enzyme]] that in humans is encoded by the ''ADAM23'' [[gene]].<ref name="pmid9693107">{{cite journal | vauthors = Sagane K, Ohya Y, Hasegawa Y, Tanaka I | title = Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain | journal = The Biochemical Journal | volume = 334 ( Pt 1) | issue = Pt 1 | pages = 93–8 | date = Aug 1998 | pmid = 9693107 | pmc = 1219666 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADAM23 ADAM metallopeptidase domain 23| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8745| accessdate = }}</ref>
'''Disintegrin and metalloproteinase domain-containing protein 23''' is a non-catalytic protein that in humans is encoded by the ''ADAM23'' [[gene]].<ref name="pmid9693107">{{cite journal | vauthors = Sagane K, Ohya Y, Hasegawa Y, Tanaka I | title = Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain | journal = The Biochemical Journal | volume = 334 ( Pt 1) | issue = Pt 1 | pages = 93–8 | date = Aug 1998 | pmid = 9693107 | pmc = 1219666 | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADAM23 ADAM metallopeptidase domain 23| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8745| accessdate = }}</ref> It is a member of the [[ADAM (protein)|ADAM family]] of [[extracellular matrix]] [[metalloproteinases]].
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.[2]
Roberts CM, Tani PH, Bridges LC, Laszik Z, Bowditch RD (Oct 1999). "MDC-L, a novel metalloprotease disintegrin cysteine-rich protein family member expressed by human lymphocytes". The Journal of Biological Chemistry. 274 (41): 29251–9. doi:10.1074/jbc.274.41.29251. PMID10506182.
Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (Sep 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. doi:10.1016/S0378-1119(99)00302-9. PMID10524237.
Sun YP, Deng KJ, Wang F, Zhang J, Huang X, Qiao S, Zhao S (Jan 2004). "Two novel isoforms of Adam23 expressed in the developmental process of mouse and human brains". Gene. 325: 171–8. doi:10.1016/j.gene.2003.10.012. PMID14697522.
Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA (Jun 2004). "Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues". Nature Biotechnology. 22 (6): 724–31. doi:10.1038/nbt969. PMID15146195.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID15146197.
Costa FF, Colin C, Shinjo SM, Zanata SM, Marie SK, Sogayar MC, Camargo AA (Jun 2005). "ADAM23 methylation and expression analysis in brain tumors". Neuroscience Letters. 380 (3): 260–4. doi:10.1016/j.neulet.2005.01.050. PMID15862898.
Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R (Aug 2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nature Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID16094384.
Takada H, Imoto I, Tsuda H, Nakanishi Y, Ichikura T, Mochizuki H, Mitsufuji S, Hosoda F, Hirohashi S, Ohki M, Inazawa J (Dec 2005). "ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation". Oncogene. 24 (54): 8051–60. doi:10.1038/sj.onc.1208952. PMID16103878.
External links
The MEROPS online database for peptidases and their inhibitors: M12.979
