DCP2: Difference between revisions

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{{about|the gene and encoded protein|the Disease Control Priorities in Developing Countries Report (2nd edition)|Disease Control Priorities Project}}
{{about|the gene and encoded protein|the Disease Control Priorities in Developing Countries Report (2nd edition)|Disease Control Priorities Project}}
{{Infobox_gene}}
{{Infobox_gene}}
'''mRNA-decapping enzyme 2''' is a [[protein]] that in humans is encoded by the ''DCP2'' [[gene]].<ref name="pmid12218187">{{cite journal | vauthors = Wang Z, Jiao X, Carr-Schmid A, Kiledjian M | title = The hDcp2 protein is a mammalian mRNA decapping enzyme  pro-caratine| journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 20 | pages = 12663–8 |date=Oct 2002 | pmid = 12218187 | pmc = 130517 | doi = 10.1073/pnas.192445599 }}</ref><ref name="pmid12417715">{{cite journal | author = Lykke-Andersen J | title = Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay | journal = Mol Cell Biol | volume = 22 | issue = 23 | pages = 8114–21 |date=Nov 2002 | pmid = 12417715 | pmc = 134073 | doi =10.1128/MCB.22.23.8114-8121.2002  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=167227| accessdate = }}</ref>
'''mRNA-decapping enzyme 2''' is a [[protein]] that in humans is encoded by the ''DCP2'' [[gene]].<ref name="pmid12218187">{{cite journal | vauthors = Wang Z, Jiao X, Carr-Schmid A, Kiledjian M | title = The hDcp2 protein is a mammalian mRNA decapping enzyme  pro-caratine| journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 20 | pages = 12663–8 |date=Oct 2002 | pmid = 12218187 | pmc = 130517 | doi = 10.1073/pnas.192445599 | bibcode = 2002PNAS...9912663W }}</ref><ref name="pmid12417715">{{cite journal | author = Lykke-Andersen J | title = Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay | journal = Mol Cell Biol | volume = 22 | issue = 23 | pages = 8114–21 |date=Nov 2002 | pmid = 12417715 | pmc = 134073 | doi =10.1128/MCB.22.23.8114-8121.2002  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=167227| accessdate = }}</ref>


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| citations =  
| citations =  
*{{cite journal  | vauthors=Ueno K, Kumagai T, Kijima T |title=Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer. |journal=Hum. Genet. |volume=102 |issue= 1 |pages= 63–8 |year= 1998 |pmid= 9490301 |doi=10.1007/s004390050655  |display-authors=etal}}
*{{cite journal  | vauthors=Ueno K, Kumagai T, Kijima T |title=Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer. |journal=Hum. Genet. |volume=102 |issue= 1 |pages= 63–8 |year= 1998 |pmid= 9490301 |doi=10.1007/s004390050655  |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | vauthors=van Dijk E, Cougot N, Meyer S |title=Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6915–24 |year= 2004 |pmid= 12486012 |doi=10.1093/emboj/cdf678  | pmc=139098  |display-authors=etal}}
*{{cite journal  | vauthors=van Dijk E, Cougot N, Meyer S |title=Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6915–24 |year= 2004 |pmid= 12486012 |doi=10.1093/emboj/cdf678  | pmc=139098  |display-authors=etal}}
*{{cite journal  | vauthors=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489–501 |year= 2003 |pmid= 12515382 |doi=  10.1017/S1355838202021726| pmc=1370355  }}
*{{cite journal  | vauthors=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489–501 |year= 2003 |pmid= 12515382 |doi=  10.1017/S1355838202021726| pmc=1370355  }}

Latest revision as of 07:17, 23 June 2018

This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see Disease Control Priorities Project.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.[1][2][3]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][3]

Interactions

DCP2 has been shown to interact with DCP1A[4] and UPF1.[2][5]

References

  1. ↑ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A. 99 (20): 12663–8. Bibcode:2002PNAS...9912663W. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.
  2. ↑ 2.0 2.1 Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
  3. ↑ 3.0 3.1 "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".
  4. ↑ Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. United States. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.
  5. ↑ Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. United States. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413.

Further reading



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