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{{about|the gene and encoded protein|the Disease Control Priorities in Developing Countries Report (2nd edition)|Disease Control Priorities Project}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''mRNA-decapping enzyme 2''' is a [[protein]] that in humans is encoded by the ''DCP2'' [[gene]].<ref name="pmid12218187">{{cite journal | vauthors = Wang Z, Jiao X, Carr-Schmid A, Kiledjian M | title = The hDcp2 protein is a mammalian mRNA decapping enzyme  pro-caratine| journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 20 | pages = 12663–8 |date=Oct 2002 | pmid = 12218187 | pmc = 130517 | doi = 10.1073/pnas.192445599 | bibcode = 2002PNAS...9912663W }}</ref><ref name="pmid12417715">{{cite journal | author = Lykke-Andersen J | title = Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay | journal = Mol Cell Biol | volume = 22 | issue = 23 | pages = 8114–21 |date=Nov 2002 | pmid = 12417715 | pmc = 134073 | doi =10.1128/MCB.22.23.8114-8121.2002 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=167227| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = DCP2 decapping enzyme homolog (S. cerevisiae)
  | HGNCid = 24452
| Symbol = DCP2
| AltSymbols =; FLJ33245; NUDT20
| OMIM = 609844
| ECnumber =
| Homologene = 13968
| MGIid = 1917890
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000184 |text = mRNA catabolic process, nonsense-mediated decay}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 167227
    | Hs_Ensembl = ENSG00000172795
    | Hs_RefseqProtein = NP_689837
    | Hs_RefseqmRNA = NM_152624
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 112340332
    | Hs_GenLoc_end = 112377080
    | Hs_Uniprot = Q8IU60
    | Mm_EntrezGene = 70640
    | Mm_Ensembl = ENSMUSG00000024472
    | Mm_RefseqmRNA = XM_140308
    | Mm_RefseqProtein = XP_140308
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 44505840
    | Mm_GenLoc_end = 44543282
    | Mm_Uniprot = Q3TLD9
  }}
}}
'''DCP2 decapping enzyme homolog (S. cerevisiae)''', also known as '''DCP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=167227| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=167227| accessdate = }}</ref>
| summary_text = DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]<ref name="entrez" />
}}
}}
==Interactions==
DCP2 has been shown to [[Protein-protein interaction|interact]] with [[DCP1A]]<ref name=autogenerated1>{{cite journal |doi=10.1128/MCB.22.23.8114-8121.2002 |last=Lykke-Andersen |first=Jens |date=Dec 2002 |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay |journal=Mol. Cell. Biol. |volume=22 |issue=23 |pages=8114–21 |publisher= |location = United States| issn = 0270-7306| pmid = 12417715 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=134073 }}</ref> and [[UPF1]].<ref name=pmid12417715/><ref name=pmid14527413>{{cite journal |doi=10.1016/S1097-2765(03)00349-6 |last=Lejeune |first=Fabrice |author2=Li Xiaojie |author3=Maquat Lynne E  |date=Sep 2003 |title=Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities |journal=Mol. Cell |volume=12 |issue=3 |pages=675–87 |publisher= |location = United States| issn = 1097-2765| pmid = 14527413 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ueno K, Kumagai T, Kijima T, ''et al.'' |title=Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer. |journal=Hum. Genet. |volume=102 |issue= 1 |pages= 63-8 |year= 1998 |pmid= 9490301 |doi=  }}
*{{cite journal  | vauthors=Ueno K, Kumagai T, Kijima T |title=Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer. |journal=Hum. Genet. |volume=102 |issue= 1 |pages= 63–8 |year= 1998 |pmid= 9490301 |doi=10.1007/s004390050655 |display-authors=etal}}
*{{cite journal  | author=Wang Z, Jiao X, Carr-Schmid A, Kiledjian M |title=The hDcp2 protein is a mammalian mRNA decapping enzyme. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 12663-8 |year= 2002 |pmid= 12218187 |doi= 10.1073/pnas.192445599 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Lykke-Andersen J |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8114-21 |year= 2003 |pmid= 12417715 |doi=  }}
*{{cite journal  | vauthors=van Dijk E, Cougot N, Meyer S |title=Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6915–24 |year= 2004 |pmid= 12486012 |doi=10.1093/emboj/cdf678  | pmc=139098 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489–501 |year= 2003 |pmid= 12515382 |doi= 10.1017/S1355838202021726| pmc=1370355 }}
*{{cite journal  | author=van Dijk E, Cougot N, Meyer S, ''et al.'' |title=Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |journal=EMBO J. |volume=21 |issue= 24 |pages= 6915-24 |year= 2004 |pmid= 12486012 |doi=  }}
*{{cite journal  | author=Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T |title=The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. |journal=RNA |volume=8 |issue= 12 |pages= 1489-501 |year= 2003 |pmid= 12515382 |doi=  }}
*{{cite journal  | author=Grzymski EC |title=Visualizing an mRNA destruction line. |journal=Nat. Struct. Biol. |volume=10 |issue= 6 |pages= 416 |year= 2003 |pmid= 12768200 |doi= 10.1038/nsb0603-416 }}
*{{cite journal  | author=Grzymski EC |title=Visualizing an mRNA destruction line. |journal=Nat. Struct. Biol. |volume=10 |issue= 6 |pages= 416 |year= 2003 |pmid= 12768200 |doi= 10.1038/nsb0603-416 }}
*{{cite journal  | author=Piccirillo C, Khanna R, Kiledjian M |title=Functional characterization of the mammalian mRNA decapping enzyme hDcp2. |journal=RNA |volume=9 |issue= 9 |pages= 1138-47 |year= 2003 |pmid= 12923261 |doi=  }}
*{{cite journal  | vauthors=Piccirillo C, Khanna R, Kiledjian M |title=Functional characterization of the mammalian mRNA decapping enzyme hDcp2. |journal=RNA |volume=9 |issue= 9 |pages= 1138–47 |year= 2003 |pmid= 12923261 |doi=10.1261/rna.5690503  | pmc=1370477 }}
*{{cite journal  | author=Lejeune F, Li X, Maquat LE |title=Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 675-87 |year= 2003 |pmid= 14527413 |doi=  }}
*{{cite journal  | vauthors=Lejeune F, Li X, Maquat LE |title=Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 675–87 |year= 2003 |pmid= 14527413 |doi=10.1016/S1097-2765(03)00349-6 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Cougot N, Babajko S, Séraphin B |title=Cytoplasmic foci are sites of mRNA decay in human cells. |journal=J. Cell Biol. |volume=165 |issue= 1 |pages= 31-40 |year= 2004 |pmid= 15067023 |doi= 10.1083/jcb.200309008 }}
*{{cite journal  | vauthors=Cougot N, Babajko S, Séraphin B |title=Cytoplasmic foci are sites of mRNA decay in human cells. |journal=J. Cell Biol. |volume=165 |issue= 1 |pages= 31–40 |year= 2004 |pmid= 15067023 |doi= 10.1083/jcb.200309008 | pmc=2172085 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | vauthors=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal  | author=Liu SW, Jiao X, Liu H, ''et al.'' |title=Functional analysis of mRNA scavenger decapping enzymes. |journal=RNA |volume=10 |issue= 9 |pages= 1412-22 |year= 2004 |pmid= 15273322 |doi= 10.1261/rna.7660804 }}
*{{cite journal  | vauthors=Liu SW, Jiao X, Liu H |title=Functional analysis of mRNA scavenger decapping enzymes. |journal=RNA |volume=10 |issue= 9 |pages= 1412–22 |year= 2004 |pmid= 15273322 |doi= 10.1261/rna.7660804 | pmc=1370627 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R |title=MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 719-23 |year= 2005 |pmid= 15937477 |doi= 10.1038/ncb1274 }}
*{{cite journal  | vauthors=Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R |title=MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 719–23 |year= 2005 |pmid= 15937477 |doi= 10.1038/ncb1274 | pmc=1855297 }}
*{{cite journal  | author=Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J |title=Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. |journal=Mol. Cell |volume=20 |issue= 6 |pages= 905-15 |year= 2006 |pmid= 16364915 |doi= 10.1016/j.molcel.2005.10.031 }}
*{{cite journal  | vauthors=Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J |title=Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. |journal=Mol. Cell |volume=20 |issue= 6 |pages= 905–15 |year= 2006 |pmid= 16364915 |doi= 10.1016/j.molcel.2005.10.031 }}
*{{cite journal  | author=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 }}
*{{cite journal  | vauthors=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041 | pmc=1458959 }}
*{{cite journal  | author=Chu CY, Rana TM |title=Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. |journal=PLoS Biol. |volume=4 |issue= 7 |pages= e210 |year= 2006 |pmid= 16756390 |doi= 10.1371/journal.pbio.0040210 }}
*{{cite journal  | vauthors=Chu CY, Rana TM |title=Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. |journal=PLoS Biol. |volume=4 |issue= 7 |pages= e210 |year= 2006 |pmid= 16756390 |doi= 10.1371/journal.pbio.0040210 | pmc=1475773 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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{{Post transcriptional modification}}
 
 
{{gene-5-stub}}
 
[[Category:Nudix hydrolases]]

Latest revision as of 07:17, 23 June 2018

This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see Disease Control Priorities Project.
VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.[1][2][3]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][3]

Interactions

DCP2 has been shown to interact with DCP1A[4] and UPF1.[2][5]

References

  1. ↑ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A. 99 (20): 12663–8. Bibcode:2002PNAS...9912663W. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.
  2. ↑ 2.0 2.1 Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
  3. ↑ 3.0 3.1 "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".
  4. ↑ Lykke-Andersen, Jens (Dec 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. United States. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.
  5. ↑ Lejeune, Fabrice; Li Xiaojie; Maquat Lynne E (Sep 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell. United States. 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413.

Further reading



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