OR2H2: Difference between revisions

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Latest revision as of 19:39, 13 March 2018

Olfactory receptor 2H2 is a protein that in humans is encoded by the OR2H2 gene.^[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[1]

References

↑ ^1.0 ^1.1 "Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2".

Fan W, Liu YC, Parimoo S, Weissman SM (1995). "Olfactory receptor-like genes are located in the human major histocompatibility complex". Genomics. 27 (1): 119–23. doi:10.1006/geno.1995.1013. PMID 7665158.
Fan W, Cai W, Parimoo S, et al. (1996). "Identification of seven new human MHC class I region genes around the HLA-F locus". Immunogenetics. 44 (2): 97–103. doi:10.1007/BF02660056. PMID 8662070.
Eklund AC, Belchak MM, Lapidos K, et al. (2000). "Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites". Hum. Immunol. 61 (7): 711–7. doi:10.1016/S0198-8859(00)00132-4. PMID 10880742.
Younger RM, Amadou C, Bethel G, et al. (2001). "Characterization of clustered MHC-linked olfactory receptor genes in human and mouse". Genome Res. 11 (4): 519–30. doi:10.1101/gr.160301. PMC 311051. PMID 11282967.
Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Santos PS, Kellermann T, Uchanska-Ziegler B, et al. (2010). "Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species". Immunogenetics. 62 (9): 569–84. doi:10.1007/s00251-010-0468-6. PMID 20680261.

External links

OR2H2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2".

[1]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
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+'''Olfactory receptor 2H2''' is a [[protein]] that in humans is encoded by the ''OR2H2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7932| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Olfactory receptor, family 2, subfamily H, member 2
- | HGNCid = 8253
- | Symbol = OR2H2
- | AltSymbols =; FAT11; MGC126732; MGC138381; OLFR 42B; OLFR2; OR2H3; dJ271M21.2; hs6M1-12
- | OMIM = 600578
- | ECnumber =
- | Homologene = 68546
- | MGIid = 2177473
- | GeneAtlas_image1 = PBB_GE_OR2H2_208573_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_OR2H2_217081_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0007618 |text = mating}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 7932
-    | Hs_Ensembl = ENSG00000204657
-    | Hs_RefseqProtein = NP_009091
-    | Hs_RefseqmRNA = NM_007160
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 29663211
-    | Hs_GenLoc_end = 29664794
-    | Hs_Uniprot = O95918
-    | Mm_EntrezGene = 258469
-    | Mm_Ensembl = ENSMUSG00000056600
-    | Mm_RefseqmRNA = NM_146477
-    | Mm_RefseqProtein = NP_666688
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 36693284
-    | Mm_GenLoc_end = 36694216
-    | Mm_Uniprot =
-  }}
-}}
-'''Olfactory receptor, family 2, subfamily H, member 2''', also known as '''OR2H2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7932| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7932| accessdate = }}</ref>
+| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR2H2 olfactory receptor, family 2, subfamily H, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7932| accessdate = }}</ref>
 }}
@@ Line 59: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 65: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Fan W, Liu YC, Parimoo S, Weissman SM |title=Olfactory receptor-like genes are located in the human major histocompatibility complex. |journal=Genomics |volume=27 |issue= 1 |pages= 119-23 |year= 1995 |pmid= 7665158 |doi= 10.1006/geno.1995.1013 }}
+*{{cite journal  | vauthors=Fan W, Liu YC, Parimoo S, Weissman SM |title=Olfactory receptor-like genes are located in the human major histocompatibility complex. |journal=Genomics |volume=27 |issue= 1 |pages= 119–23 |year= 1995 |pmid= 7665158 |doi= 10.1006/geno.1995.1013 }}
-*{{cite journal  | author=Fan W, Cai W, Parimoo S, ''et al.'' |title=Identification of seven new human MHC class I region genes around the HLA-F locus. |journal=Immunogenetics |volume=44 |issue= 2 |pages= 97-103 |year= 1996 |pmid= 8662070 |doi=  }}
+*{{cite journal   |vauthors=Fan W, Cai W, Parimoo S, etal |title=Identification of seven new human MHC class I region genes around the HLA-F locus. |journal=Immunogenetics |volume=44 |issue= 2 |pages= 97–103 |year= 1996 |pmid= 8662070 |doi=10.1007/BF02660056  }}
-*{{cite journal  | author=Eklund AC, Belchak MM, Lapidos K, ''et al.'' |title=Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites. |journal=Hum. Immunol. |volume=61 |issue= 7 |pages= 711-7 |year= 2000 |pmid= 10880742 |doi=  }}
+*{{cite journal   |vauthors=Eklund AC, Belchak MM, Lapidos K, etal |title=Polymorphisms in the HLA-linked olfactory receptor genes in the Hutterites. |journal=Hum. Immunol. |volume=61 |issue= 7 |pages= 711–7 |year= 2000 |pmid= 10880742 |doi=10.1016/S0198-8859(00)00132-4  }}
-*{{cite journal  | author=Younger RM, Amadou C, Bethel G, ''et al.'' |title=Characterization of clustered MHC-linked olfactory receptor genes in human and mouse. |journal=Genome Res. |volume=11 |issue= 4 |pages= 519-30 |year= 2001 |pmid= 11282967 |doi= 10.1101/gr.160301 }}
+*{{cite journal   |vauthors=Younger RM, Amadou C, Bethel G, etal |title=Characterization of clustered MHC-linked olfactory receptor genes in human and mouse. |journal=Genome Res. |volume=11 |issue= 4 |pages= 519–30 |year= 2001 |pmid= 11282967 |doi= 10.1101/gr.160301  | pmc=311051 }}
-*{{cite journal  | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi=  }}
+*{{cite journal   |vauthors=Fuchs T, Malecova B, Linhart C, etal |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Volz A, Ehlers A, Younger R, ''et al.'' |title=Complex transcription and splicing of odorant receptor genes. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 19691-701 |year= 2003 |pmid= 12637542 |doi= 10.1074/jbc.M212424200 }}
+*{{cite journal   |vauthors=Volz A, Ehlers A, Younger R, etal |title=Complex transcription and splicing of odorant receptor genes. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 19691–701 |year= 2003 |pmid= 12637542 |doi= 10.1074/jbc.M212424200 }}
-*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
+*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
-*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
+*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993  }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
+*{{cite journal   |vauthors=Santos PS, Kellermann T, Uchanska-Ziegler B, etal |title=Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species. |journal=Immunogenetics |volume=62 |issue=9 |pages=569–84 |year=2010 |pmid=20680261 |doi=10.1007/s00251-010-0468-6 }}
 }}
 {{refend}}
@@ Line 82: / Line 36: @@
 {{NLM content}}
-{{membrane-protein-stub}}
 {{Olfactory receptors}}
-[[Category:G protein coupled receptors]]
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+| update_page = yes
+| require_manual_inspection = no
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+| update_citations = yes
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+[[Category:Olfactory receptors]]
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OR2H2: Difference between revisions

Latest revision as of 19:39, 13 March 2018

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References

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