Chemerin peptide: Difference between revisions
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A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.<ref>{{cite journal|doi=10.1084/jem.20071601|last=cash|first=J|author2=Cash JL|author3=Hart R|author4=Russ A|author5=Dixon JP|author6=Colledge WH|author7=Doran J|author8=Hendrick AG|author9=Carlton MB|author10=Greaves DR|title=Synthetic chemerin-derived peptides suppress inflammation through ChemR23|journal=J. Exp. Med.|date=Apr 2008|volume= 205 | issue=4|pages=767–75|pmid=18391062|pmc=2292217 }}</ref> | A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.<ref>{{cite journal|doi=10.1084/jem.20071601|last=cash|first=J|author2=Cash JL|author3=Hart R|author4=Russ A|author5=Dixon JP|author6=Colledge WH|author7=Doran J|author8=Hendrick AG|author9=Carlton MB|author10=Greaves DR|title=Synthetic chemerin-derived peptides suppress inflammation through ChemR23|journal=J. Exp. Med.|date=Apr 2008|volume= 205 | issue=4|pages=767–75|pmid=18391062|pmc=2292217 }}</ref> | ||
C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro <ref>{{cite journal|last=Cash|first=J|author2=Greaves DR|title=Chemerin peptides promote phagocytosis in a ChemR23 and Syk dependent manner|journal=J | C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro <ref>{{cite journal|last=Cash|first=J|author2=Greaves DR|title=Chemerin peptides promote phagocytosis in a ChemR23 and Syk dependent manner|journal=J. Immunol.|volume=184|issue=9|pages=5315–24|date=May 2010|pmid= 20363975|doi=10.4049/jimmunol.0903378|pmc=4237835}}</ref> | ||
==References== | ==References== | ||
Latest revision as of 21:13, 15 May 2018
| retinoic acid receptor responder (tazarotene induced) 2 | |
|---|---|
| Identifiers | |
| Symbol | RARRES2 |
| Alt. symbols | chemerin |
| Entrez | 5919 |
| HUGO | 9868 |
| OMIM | 601973 |
| RefSeq | NM_002889 |
| UniProt | Q99969 |
| Other data | |
| Locus | Chr. 7 q36.1 |
Chemerin Peptides are short peptides (on the order of 9 amino acids) that are produced from the carboxyl terminus of the chemokine chemerin. They display the same activities as chemerin, although at higher efficacy and potency.[1]
A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.[2]
C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro [3]
References
- ↑ Wittamer V, Grégoire F, Robberecht P, Vassart G, Communi D, Parmentier M (March 2004). "The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency". J. Biol. Chem. 279 (11): 9956–62. doi:10.1074/jbc.M313016200. PMID 14701797.
- ↑ cash, J; Cash JL; Hart R; Russ A; Dixon JP; Colledge WH; Doran J; Hendrick AG; Carlton MB; Greaves DR (Apr 2008). "Synthetic chemerin-derived peptides suppress inflammation through ChemR23". J. Exp. Med. 205 (4): 767–75. doi:10.1084/jem.20071601. PMC 2292217. PMID 18391062.
- ↑ Cash, J; Greaves DR (May 2010). "Chemerin peptides promote phagocytosis in a ChemR23 and Syk dependent manner". J. Immunol. 184 (9): 5315–24. doi:10.4049/jimmunol.0903378. PMC 4237835. PMID 20363975.
See also
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