CENPI: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}})
 
imported>Jabberjaw
clean up
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
'''Centromere protein I''' is a [[protein]] that in humans is encoded by the ''CENPI'' [[gene]].<ref name="pmid16622420">{{cite journal | vauthors = Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T | title = The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 446–57 | date = May 2006 | pmid = 16622420 | pmc = | doi = 10.1038/ncb1396 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CENPI centromere protein I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2491| access-date = }}</ref>
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Centromere protein I
| HGNCid = 3968
| Symbol = CENPI
| AltSymbols =; CENP-I; FSHPRH1; LRPR1; Mis6
| OMIM = 300065
| ECnumber =
| Homologene = 4899
| MGIid = 2147897
| GeneAtlas_image1 = PBB_GE_CENPI_214804_at_tn.png
| GeneAtlas_image2 = PBB_GE_CENPI_207590_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0000775 |text = chromosome, pericentric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0007292 |text = female gamete generation}} {{GNF_GO|id=GO:0007548 |text = sex differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2491
    | Hs_Ensembl = ENSG00000102384
    | Hs_RefseqProtein = NP_006724
    | Hs_RefseqmRNA = NM_006733
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 100242082
    | Hs_GenLoc_end = 100305326
    | Hs_Uniprot = Q92674
    | Mm_EntrezGene = 102920
    | Mm_Ensembl = ENSMUSG00000031262
    | Mm_RefseqmRNA = XM_975916
    | Mm_RefseqProtein = XP_981010
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 129654505
    | Mm_GenLoc_end = 129708989
    | Mm_Uniprot = Q3TLU9
  }}
}}
'''Centromere protein I''', also known as '''CENPI''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CENPI centromere protein I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2491| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{PBB_Summary
The product of this gene is involved in the response of gonadal tissues to [[follicle-stimulating hormone]]. This gene is also a potential candidate for human X-linked disorders of gonadal development and [[gametogenesis]].<ref name="entrez"/> CENPI is a target gene of the [[transcription factor]] [[E2F]].<ref name=Thangavelu2017>{{cite journal | vauthors = Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH | title = CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer | journal = Oncotarget | volume = 8 | issue = 37 | pages = 62167–62182 | date = September 2017 | pmid = 28977935 | doi = 10.18632/oncotarget.19131 }}</ref> Additionally, CENPI expression is increased in [[breast cancer]] and this has been shown to cause [[chromosome instability]] in breast cancer cells.<ref name=Thangavelu2017/>
| section_title =  
| summary_text = The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: CENPI centromere protein I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2491| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K | title = Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells | journal = Genes to Cells | volume = 11 | issue = 6 | pages = 673–84 | date = June 2006 | pmid = 16716197 | doi = 10.1111/j.1365-2443.2006.00969.x }}
| citations =
* {{cite journal | vauthors = Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW | title = The human CENP-A centromeric nucleosome-associated complex | journal = Nature Cell Biology | volume = 8 | issue = 5 | pages = 458–69 | date = May 2006 | pmid = 16622419 | doi = 10.1038/ncb1397 }}
*{{cite journal | author=Izuta H, Ikeno M, Suzuki N, ''et al.'' |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673-84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = April 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Okada M, Cheeseman IM, Hori T, ''et al.'' |title=The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 446-57 |year= 2006 |pmid= 16622420 |doi= 10.1038/ncb1396 }}
* {{cite journal | vauthors = Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K | title = Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase | journal = Genes to Cells | volume = 9 | issue = 2 | pages = 105–20 | date = February 2004 | pmid = 15009096 | doi = 10.1111/j.1365-2443.2004.00705.x }}
*{{cite journal  | author=Foltz DR, Jansen LE, Black BE, ''et al.'' |title=The human CENP-A centromeric nucleosome-associated complex. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 458-69 |year= 2006 |pmid= 16622419 |doi= 10.1038/ncb1397 }}
* {{cite journal | vauthors = Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ | title = Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis | journal = Nature Cell Biology | volume = 5 | issue = 4 | pages = 341–5 | date = April 2003 | pmid = 12640463 | doi = 10.1038/ncb953 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
* {{cite journal | vauthors = Roberts RG, Kendall E, Vetrie D, Bobrow M | title = Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene | journal = Genomics | volume = 37 | issue = 1 | pages = 122–4 | date = October 1996 | pmid = 8921378 | doi = 10.1006/geno.1996.0528 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
* {{cite journal | vauthors = Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA | title = Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein | journal = Molecular and Cellular Endocrinology | volume = 108 | issue = 1-2 | pages = 115–24 | date = February 1995 | pmid = 7758824 | doi = 10.1016/0303-7207(94)03468-9 | hdl = 1765/64471 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC | title = Sequence identification of 2,375 human brain genes | journal = Nature | volume = 355 | issue = 6361 | pages = 632–4 | date = February 1992 | pmid = 1538749 | doi = 10.1038/355632a0 }}
*{{cite journal  | author=Obuse C, Yang H, Nozaki N, ''et al.'' |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105-20 |year= 2004 |pmid= 15009096 |doi= }}
*{{cite journal | author=Liu ST, Hittle JC, Jablonski SA, ''et al.'' |title=Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. |journal=Nat. Cell Biol. |volume=5 |issue= 4 |pages= 341-5 |year= 2003 |pmid= 12640463 |doi= 10.1038/ncb953 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Roberts RG, Kendall E, Vetrie D, Bobrow M |title=Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene. |journal=Genomics |volume=37 |issue= 1 |pages= 122-4 |year= 1997 |pmid= 8921378 |doi= 10.1006/geno.1996.0528 }}
*{{cite journal | author=Slegtenhorst-Eegdeman KE, Post M, Baarends WM, ''et al.'' |title=Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein. |journal=Mol. Cell. Endocrinol. |volume=108 |issue= 1-2 |pages= 115-24 |year= 1995 |pmid= 7758824 |doi= }}
*{{cite journal | author=Adams MD, Dubnick M, Kerlavage AR, ''et al.'' |title=Sequence identification of 2,375 human brain genes. |journal=Nature |volume=355 |issue= 6361 |pages= 632-4 |year= 1992 |pmid= 1538749 |doi= 10.1038/355632a0 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
* {{UCSC gene info|CENPI}}
 
{{Chromosome genetics}}
{{Chromosome genetics}}
{{WikiDoc Sources}}
 
 
{{gene-X-stub}}

Latest revision as of 07:13, 28 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Centromere protein I is a protein that in humans is encoded by the CENPI gene.[1][2]

Function

The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.[2] CENPI is a target gene of the transcription factor E2F.[3] Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.[3]

References

  1. ↑ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420.
  2. ↑ 2.0 2.1 "Entrez Gene: CENPI centromere protein I".
  3. ↑ 3.0 3.1 Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017). "CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer". Oncotarget. 8 (37): 62167–62182. doi:10.18632/oncotarget.19131. PMID 28977935.

Further reading

  • Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
  • Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
  • Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ (April 2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis". Nature Cell Biology. 5 (4): 341–5. doi:10.1038/ncb953. PMID 12640463.
  • Roberts RG, Kendall E, Vetrie D, Bobrow M (October 1996). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene". Genomics. 37 (1): 122–4. doi:10.1006/geno.1996.0528. PMID 8921378.
  • Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA (February 1995). "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein". Molecular and Cellular Endocrinology. 108 (1–2): 115–24. doi:10.1016/0303-7207(94)03468-9. hdl:1765/64471. PMID 7758824.
  • Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (February 1992). "Sequence identification of 2,375 human brain genes". Nature. 355 (6361): 632–4. doi:10.1038/355632a0. PMID 1538749.

External links


Retrieved from "https://www.wikidoc.org/index.php?title=CENPI&oldid=1534233"