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{{Infobox_gene}}
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'''Cbp/p300-interacting transactivator 1''' is a [[protein]] that in humans is encoded by the ''CITED1'' [[gene]].<ref name="pmid8901575">{{cite journal | vauthors = Shioda T, Fenner MH, Isselbacher KJ | title = msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation | journal = Proc Natl Acad Sci U S A | volume = 93 | issue = 22 | pages = 12298–303 |date=December 1996 | pmid = 8901575 | pmc = 37985 | doi =10.1073/pnas.93.22.12298 | bibcode = 1996PNAS...9312298S }}</ref><ref name="pmid9721210">{{cite journal | vauthors = Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T | title = MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis | journal = Genomics | volume = 51 | issue = 3 | pages = 401–7 |date=October 1998 | pmid = 9721210 | pmc =  | doi = 10.1006/geno.1998.5383 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4435| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
| HGNCid = 1986
| Symbol = CITED1
| AltSymbols =; MSG1
| OMIM = 300149
| ECnumber =
| Homologene = 3057
| MGIid = 108023
| GeneAtlas_image1 = PBB_GE_CITED1_207144_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0001570 |text = vasculogenesis}} {{GNF_GO|id=GO:0001892 |text = embryonic placenta development}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0030318 |text = melanocyte differentiation}} {{GNF_GO|id=GO:0043473 |text = pigmentation}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4435
    | Hs_Ensembl = ENSG00000125931
    | Hs_RefseqProtein = NP_004134
    | Hs_RefseqmRNA = NM_004143
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 71438222
    | Hs_GenLoc_end = 71443762
    | Hs_Uniprot = Q99966
    | Mm_EntrezGene = 12705
    | Mm_Ensembl = ENSMUSG00000051159
    | Mm_RefseqmRNA = NM_007709
    | Mm_RefseqProtein = NP_031735
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 98450100
    | Mm_GenLoc_end = 98454882
    | Mm_Uniprot = Q3UGA1
  }}
}}
'''Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1''', also known as '''CITED1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4435| accessdate = }}</ref>


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| summary_text =  
}}
}}
==Interactions==
CITED1 has been shown to [[Protein-protein interaction|interact]] with [[HSPA8]]<ref name=pmid10722728>{{cite journal |last=Yahata |first=T |author2=de Caestecker M P |author3=Lechleider R J |author4=Andriole S |author5=Roberts A B |author6=Isselbacher K J |author7=Shioda T  |date=March 2000  |title=The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors |journal=J. Biol. Chem. |volume=275 |issue=12 |pages=8825–34 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10722728 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.275.12.8825 }}</ref> and [[EP300]].<ref name=pmid10722728/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==External links==
* {{UCSC gene info|CITED1}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Shioda T, Fenner MH, Isselbacher KJ |title=msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12298-303 |year= 1996 |pmid= 8901575 |doi=  }}
*{{cite journal  | vauthors=Shioda T, Fenner MH, Isselbacher KJ |title=MSG1 and its related protein MRG1 share a transcription activating domain. |journal=Gene |volume=204 |issue= 1–2 |pages= 235–41 |year= 1998 |pmid= 9434189 |doi=10.1016/S0378-1119(97)00551-9 }}
*{{cite journal  | author=Shioda T, Fenner MH, Isselbacher KJ |title=MSG1 and its related protein MRG1 share a transcription activating domain. |journal=Gene |volume=204 |issue= 1-2 |pages= 235-41 |year= 1998 |pmid= 9434189 |doi=  }}
*{{cite journal  | vauthors=Li H, Ahmed NU, Fenner MH |title=Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells |journal=Exp. Cell Res. |volume=242 |issue= 2 |pages= 478–86 |year= 1998 |pmid= 9683535 |doi= 10.1006/excr.1998.4123 |display-authors=etal}}
*{{cite journal  | author=Li H, Ahmed NU, Fenner MH, ''et al.'' |title=Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells. |journal=Exp. Cell Res. |volume=242 |issue= 2 |pages= 478-86 |year= 1998 |pmid= 9683535 |doi= 10.1006/excr.1998.4123 }}
*{{cite journal  | vauthors=Shioda T, Lechleider RJ, Dunwoodie SL |title=Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9785–90 |year= 1998 |pmid= 9707553 |doi=10.1073/pnas.95.17.9785  | pmc=21414  |display-authors=etal|bibcode=1998PNAS...95.9785S}}
*{{cite journal  | author=Shioda T, Lechleider RJ, Dunwoodie SL, ''et al.'' |title=Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9785-90 |year= 1998 |pmid= 9707553 |doi= }}
*{{cite journal  | vauthors=Vachtenheim J, Novotná H |title=Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=45 |issue= 7 |pages= 1075–82 |year= 2000 |pmid= 10644012 |doi=  }}
*{{cite journal  | author=Fenner MH, Parrish JE, Boyd Y, ''et al.'' |title=MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis. |journal=Genomics |volume=51 |issue= 3 |pages= 401-7 |year= 1998 |pmid= 9721210 |doi= 10.1006/geno.1998.5383 }}
*{{cite journal  | vauthors=Yahata T, de Caestecker MP, Lechleider RJ |title=The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8825–34 |year= 2000 |pmid= 10722728 |doi=10.1074/jbc.275.12.8825 |display-authors=etal}}
*{{cite journal  | author=Vachtenheim J, Novotná H |title=Expression of genes for microphthalmia isoforms, Pax3 and MSG1, in human melanomas. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=45 |issue= 7 |pages= 1075-82 |year= 2000 |pmid= 10644012 |doi=  }}
*{{cite journal  | vauthors=Ahmed NU, Shioda T, Coser KR |title=Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo |journal=Pigment Cell Res. |volume=14 |issue= 2 |pages= 140–3 |year= 2001 |pmid= 11310794 |doi=  |display-authors=etal}}
*{{cite journal  | author=Yahata T, de Caestecker MP, Lechleider RJ, ''et al.'' |title=The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8825-34 |year= 2000 |pmid= 10722728 |doi=  }}
*{{cite journal  | vauthors=Iwasaki T, Chin WW, Ko L |title=Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM) |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33375–83 |year= 2001 |pmid= 11443112 |doi= 10.1074/jbc.M101517200 }}
*{{cite journal  | author=Ahmed NU, Shioda T, Coser KR, ''et al.'' |title=Aberrant expression of MSG1 transcriptional activator in human malignant melanoma in vivo. |journal=Pigment Cell Res. |volume=14 |issue= 2 |pages= 140-3 |year= 2001 |pmid= 11310794 |doi=  }}
*{{cite journal  | vauthors=Yahata T, Shao W, Endoh H |title=Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein |journal=Genes Dev. |volume=15 |issue= 19 |pages= 2598–612 |year= 2001 |pmid= 11581164 |doi= 10.1101/gad.906301 | pmc=312794 |display-authors=etal}}
*{{cite journal  | author=Iwasaki T, Chin WW, Ko L |title=Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). |journal=J. Biol. Chem. |volume=276 |issue= 36 |pages= 33375-83 |year= 2001 |pmid= 11443112 |doi= 10.1074/jbc.M101517200 }}
*{{cite journal  | vauthors=Bragança J, Swingler T, Marques FI |title=Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2 |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8559–65 |year= 2002 |pmid= 11744733 |doi= 10.1074/jbc.M110850200 |display-authors=etal}}
*{{cite journal  | author=Yahata T, Shao W, Endoh H, ''et al.'' |title=Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. |journal=Genes Dev. |volume=15 |issue= 19 |pages= 2598-612 |year= 2001 |pmid= 11581164 |doi= 10.1101/gad.906301 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Bragança J, Swingler T, Marques FI, ''et al.'' |title=Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8559-65 |year= 2002 |pmid= 11744733 |doi= 10.1074/jbc.M110850200 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Shi G, Boyle SC, Sparrow DB |title=The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 27426–35 |year= 2006 |pmid= 16864582 |doi= 10.1074/jbc.M602631200 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Lovvorn HN, Westrup J, Opperman S |title=CITED1 expression in Wilms' tumor and embryonic kidney |journal=Neoplasia |volume=9 |issue= 7 |pages= 589–600 |year= 2007 |pmid= 17710162 |doi=10.1593/neo.07358  | pmc=1941694 |display-authors=etal}}
*{{cite journal  | author=Shi G, Boyle SC, Sparrow DB, ''et al.'' |title=The transcriptional activity of CITED1 is regulated by phosphorylation in a cell cycle-dependent manner. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 27426-35 |year= 2006 |pmid= 16864582 |doi= 10.1074/jbc.M602631200 }}
*{{cite journal  | author=Lovvorn HN, Westrup J, Opperman S, ''et al.'' |title=CITED1 expression in Wilms' tumor and embryonic kidney. |journal=Neoplasia |volume=9 |issue= 7 |pages= 589-600 |year= 2007 |pmid= 17710162 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 01:10, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.[1][2][3]


Interactions

CITED1 has been shown to interact with HSPA8[4] and EP300.[4]

References

  1. ↑ Shioda T, Fenner MH, Isselbacher KJ (December 1996). "msg1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation". Proc Natl Acad Sci U S A. 93 (22): 12298–303. Bibcode:1996PNAS...9312298S. doi:10.1073/pnas.93.22.12298. PMC 37985. PMID 8901575.
  2. ↑ Fenner MH, Parrish JE, Boyd Y, Reed V, MacDonald M, Nelson DL, Isselbacher KJ, Shioda T (October 1998). "MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis". Genomics. 51 (3): 401–7. doi:10.1006/geno.1998.5383. PMID 9721210.
  3. ↑ "Entrez Gene: CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1".
  4. ↑ 4.0 4.1 Yahata, T; de Caestecker M P; Lechleider R J; Andriole S; Roberts A B; Isselbacher K J; Shioda T (March 2000). "The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors". J. Biol. Chem. UNITED STATES. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. ISSN 0021-9258. PMID 10722728.

External links

Further reading



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