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{{ | '''[[Breast cancer]] [[metastasis suppressor]] 1''' is a [[protein]] that in [[human]]s is encoded by the ''BRMS1'' [[gene]].<ref name="pmid10850410">{{cite journal | vauthors = Seraj MJ, Samant RS, Verderame MF, Welch DR | title = Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13 | journal = [[Cancer Research (journal)|Cancer Research]] | volume = 60 | issue = 11 | pages = 2764–9 |date=Jun 2000 | pmid = 10850410 | pmc = | doi = }}</ref><ref name="entrez"/> | ||
}} | |||
'''Breast cancer [[metastasis suppressor]] 1''' | |||
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | <!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. --> | ||
{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell | | summary_text = This gene reduces the [[metastasis|metastatic]] potential, but not the tumorogenicity, of human breast cancer and [[melanoma]] [[cell line]]s.<ref>[https://www.sciencedaily.com/releases/2000/06/000612084928.htm Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene<!-- Bot generated title -->]</ref> The protein encoded by this gene localizes primarily to the [[cell nucleus|nucleus]], and is a component of the mSin3a family of [[histone deacetylase]] complexes (HDAC). The protein contains two [[coiled-coil]] [[Structural motif|motif]]s and several imperfect [[leucine]] zipper motifs. [[Alternative splicing]] results in two [[primary transcript|transcript]] variants encoding different [[protein isoform|isoform]]s.<ref name="entrez">{{cite web | title = Entrez Gene: BRMS1 breast cancer metastasis suppressor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25855| accessdate = }}</ref> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist| | {{reflist}} | ||
==External links== | |||
* {{UCSC gene info|BRMS1}} | |||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Meehan WJ, Welch DR |title=Breast cancer metastasis suppressor 1: update. |journal=Clin. Exp. Metastasis |volume=20 |issue= 1 |pages= 45–50 |year= 2003 |pmid= 12650606 |doi=10.1023/A:1022542519586 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=[[Genome Res.]] |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }} | ||
*{{cite journal | vauthors=Samant RS, Debies MT, Shevde LA |title=Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1). |journal=[[Int. J. Cancer]] |volume=97 |issue= 1 |pages= 15–20 |year= 2002 |pmid= 11774238 |doi=10.1002/ijc.1569 |display-authors=etal}} | |||
*{{cite journal | | *{{cite journal | vauthors=Shevde LA, Samant RS, Goldberg SF |title=Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1. |journal=[[Exp. Cell Res.]] |volume=273 |issue= 2 |pages= 229–39 |year= 2002 |pmid= 11822878 |doi= 10.1006/excr.2001.5452 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Janneau JL, Maldonado-Estrada J, Tachdjian G |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=[[J. Clin. Endocrinol. Metab.]] |volume=87 |issue= 11 |pages= 5336–9 |year= 2002 |pmid= 12414911 |doi=10.1210/jc.2002-021093 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=[[Proc. Natl. Acad. Sci. U.S.A.]] |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Meehan WJ, Samant RS, Hopper JE |title=Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription |journal=[[J. Biol. Chem.]] |volume=279 |issue= 2 |pages= 1562–9 |year= 2004 |pmid= 14581478 |doi= 10.1074/jbc.M307969200 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Cicek M, Samant RS, Kinter M |title=Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells |journal=Clin. Exp. Metastasis |volume=21 |issue= 2 |pages= 149–57 |year= 2004 |pmid= 15168732 |doi=10.1023/B:CLIN.0000024729.19084.f0 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Nikolaev AY, Papanikolaou NA, Li M |title=Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex |journal=[[Biochem. Biophys. Res. Commun.]] |volume=323 |issue= 4 |pages= 1216–22 |year= 2004 |pmid= 15451426 |doi= 10.1016/j.bbrc.2004.08.227 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Stark AM, Tongers K, Maass N |title=Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases |journal=[[J. Cancer Res. Clin. Oncol.]] |volume=131 |issue= 3 |pages= 191–8 |year= 2005 |pmid= 15592684 |doi= 10.1007/s00432-004-0629-9 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=DeWald DB, Torabinejad J, Samant RS |title=Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells |journal=Cancer Res. |volume=65 |issue= 3 |pages= 713–7 |year= 2005 |pmid= 15705865 |doi= |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Cicek M, Fukuyama R, Welch DR |title=Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity |journal=Cancer Res. |volume=65 |issue= 9 |pages= 3586–95 |year= 2005 |pmid= 15867352 |doi= 10.1158/0008-5472.CAN-04-3139 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Hurst DR, Mehta A, Moore BP |title=Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 4 |pages= 1429–35 |year= 2006 |pmid= 16919237 |doi= 10.1016/j.bbrc.2006.08.005 | pmc=1557677 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Samant RS, Clark DW, Fillmore RA |title=Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation |journal=Mol. Cancer |volume=6 |issue= |pages= 6 |year= 2007 |pmid= 17227585 |doi= 10.1186/1476-4598-6-6 | pmc=1796551 |display-authors=etal}} | ||
*{{cite journal | | *{{cite journal | vauthors=Rivera J, Megias D, Bravo J |title=Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1 |journal=[[J. Proteome Res.]] |volume=6 |issue= 10 |pages= 4006–18 |year= 2007 |pmid= 17854218 |doi= 10.1021/pr0703167 }} | ||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Latest revision as of 06:08, 17 January 2019
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[1][2]
This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[3] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[2]
References
- ↑ Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research. 60 (11): 2764–9. PMID 10850410.
- ↑ 2.0 2.1 "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
- ↑ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene
External links
- Human BRMS1 genome location and BRMS1 gene details page in the UCSC Genome Browser.
Further reading
- Meehan WJ, Welch DR (2003). "Breast cancer metastasis suppressor 1: update". Clin. Exp. Metastasis. 20 (1): 45–50. doi:10.1023/A:1022542519586. PMID 12650606.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Samant RS, Debies MT, Shevde LA, et al. (2002). "Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1)". Int. J. Cancer. 97 (1): 15–20. doi:10.1002/ijc.1569. PMID 11774238.
- Shevde LA, Samant RS, Goldberg SF, et al. (2002). "Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1". Exp. Cell Res. 273 (2): 229–39. doi:10.1006/excr.2001.5452. PMID 11822878.
- Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. doi:10.1210/jc.2002-021093. PMID 12414911.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Meehan WJ, Samant RS, Hopper JE, et al. (2004). "Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription". J. Biol. Chem. 279 (2): 1562–9. doi:10.1074/jbc.M307969200. PMID 14581478.
- Cicek M, Samant RS, Kinter M, et al. (2004). "Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cells". Clin. Exp. Metastasis. 21 (2): 149–57. doi:10.1023/B:CLIN.0000024729.19084.f0. PMID 15168732.
- Nikolaev AY, Papanikolaou NA, Li M, et al. (2004). "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex". Biochem. Biophys. Res. Commun. 323 (4): 1216–22. doi:10.1016/j.bbrc.2004.08.227. PMID 15451426.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Stark AM, Tongers K, Maass N, et al. (2005). "Reduced metastasis-suppressor gene mRNA-expression in breast cancer brain metastases". J. Cancer Res. Clin. Oncol. 131 (3): 191–8. doi:10.1007/s00432-004-0629-9. PMID 15592684.
- DeWald DB, Torabinejad J, Samant RS, et al. (2005). "Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells". Cancer Res. 65 (3): 713–7. PMID 15705865.
- Cicek M, Fukuyama R, Welch DR, et al. (2005). "Breast cancer metastasis suppressor 1 inhibits gene expression by targeting nuclear factor-kappaB activity". Cancer Res. 65 (9): 3586–95. doi:10.1158/0008-5472.CAN-04-3139. PMID 15867352.
- Hurst DR, Mehta A, Moore BP, et al. (2006). "Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone". Biochem. Biophys. Res. Commun. 348 (4): 1429–35. doi:10.1016/j.bbrc.2006.08.005. PMC 1557677. PMID 16919237.
- Samant RS, Clark DW, Fillmore RA, et al. (2007). "Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation". Mol. Cancer. 6: 6. doi:10.1186/1476-4598-6-6. PMC 1796551. PMID 17227585.
- Rivera J, Megias D, Bravo J (2007). "Proteomics-based strategy to delineate the molecular mechanisms of the metastasis suppressor gene BRMS1". J. Proteome Res. 6 (10): 4006–18. doi:10.1021/pr0703167. PMID 17854218.
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