Folate deficiency diagnostic study of choice: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
 
(4 intermediate revisions by the same user not shown)
Line 3: Line 3:
{{CMG}}; {{AE}}
{{CMG}}; {{AE}}
== Overview ==
== Overview ==
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency.


== Diagnostic Study of Choice ==
== Diagnostic Study of Choice ==


=== Study of choice ===
=== Study of choice ===
[Name of the investigation] is the gold standard test for the diagnosis of [disease name].
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, <ref name="Snow1999">{{cite journal|last1=Snow|first1=Christopher F.|title=Laboratory Diagnosis of Vitamin B12 and Folate Deficiency|journal=Archives of Internal Medicine|volume=159|issue=12|year=1999|pages=1289|issn=0003-9926|doi=10.1001/archinte.159.12.1289}}</ref> but [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation.[[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency.<ref name="pmid10926922">{{cite journal| author=Klee GG| title=Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. | journal=Clin Chem | year= 2000 | volume= 46 | issue= 8 Pt 2 | pages= 1277-83 | pmid=10926922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10926922  }}</ref><ref name="pmid24942828">{{cite journal| author=Devalia V, Hamilton MS, Molloy AM, British Committee for Standards in Haematology| title=Guidelines for the diagnosis and treatment of cobalamin and folate disorders. | journal=Br J Haematol | year= 2014 | volume= 166 | issue= 4 | pages= 496-513 | pmid=24942828 | doi=10.1111/bjh.12959 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24942828  }}</ref>
 
OR
 
The following result of [gold standard test] is confirmatory of [disease name]:
* [Result 1]
* [Result 2]
 
OR
 
[Name of the investigation] must be performed when:
* The patient presents with [symptom/sign 1], [symptom/sign 2], and [symptom/sign 3].
* A [name of test] is positive for [sign 1], [sign 2], and [sign 3] in the patient.
 
OR
 
[Name of the investigation] is the gold standard test for the diagnosis of [disease name].
 
OR
 
The diagnostic study of choice for [disease name] is [name of the investigation].
 
OR
 
There is no single diagnostic study of choice for the diagnosis of [disease name].
 
OR
 
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, <ref name="Snow1999">{{cite journal|last1=Snow|first1=Christopher F.|title=Laboratory Diagnosis of Vitamin B12 and Folate Deficiency|journal=Archives of Internal Medicine|volume=159|issue=12|year=1999|pages=1289|issn=0003-9926|doi=10.1001/archinte.159.12.1289}}</ref> but [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation.[[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency.
 
 
 
OR
 
[Disease name] is primarily diagnosed based on the clinical presentation.
 
OR
 
Investigations:
* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most specific test for the diagnosis.
* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most sensitive test for diagnosis.
* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most efficient test for diagnosis.
 
==== The comparison of various diagnostic studies for [disease name] ====
{|
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! style="background: #4479BA; color: #FFFFFF; text-align: center;" | Test
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Sensitivity
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specificity
|-
! style="background: #696969; color: #FFFFFF; text-align: center;" |Test 1
| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
|-
! style="background: #696969; color: #FFFFFF; text-align: center;" |Test 2
| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
|}
<small> [Name of test with higher sensitivity and specificity] is the preferred investigation based on the sensitivity and specificity</small>
 
===== Diagnostic results =====
The following finding(s) on performing [investigation name] is(are) confirmatory for [disease name]:
* [Finding 1]
* [Finding 2]


===== Sequence of Diagnostic Studies =====
===== Sequence of Diagnostic Studies =====
The [name of investigation] must be performed when:
* The patient presented with symptoms/signs 1, 2, and 3 as the first step of diagnosis.
* A positive [test] is detected in the patient, to confirm the diagnosis.
OR
The various investigations must be performed in the following order:
The various investigations must be performed in the following order:
* [Initial investigation]
* CBC
* [2nd investigation]
* Peripheral smear
 
* Liver function test esp. indirect biluribin
=== Name of Diagnostic Criteria ===
* LDH
 
* Serum folate level
'''It is recommended that you include the criteria in a table. Make sure you always cite the source of the content and whether the table has been adapted from another source.'''
* RBC folate level
 
* plasma or serum homocysteine or methylmalonic acid
[Disease name] is primarily diagnosed based on clinical presentation. There are no established criteria for the diagnosis of [disease name].
* serum Vitamin b12 level and finally
 
* serum iron panel
OR
 
There is no single diagnostic study of choice for [disease name], though [disease name] may be diagnosed based on [name of criteria] established by [...].
 
OR
 
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
 
OR
 
The diagnosis of [disease name] is based on the [criteria name] criteria, which includes [criterion 1], [criterion 2], and [criterion 3].
 
OR
 
[Disease name] may be diagnosed at any time if one or more of the following criteria are met:
* Criteria 1
* Criteria 2
* Criteria 3
 
OR
 
'''IF there are clear, established diagnostic criteria'''
 
The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
 
OR
 
The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].
 
OR
 
The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].
 
OR
 
'''IF there are no established diagnostic criteria'''
 
There are no established criteria for the diagnosis of [disease name].


==References==
==References==

Latest revision as of 08:21, 3 February 2019

Folate deficiency Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Folate deficiency from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X ray

Echocardiography and Ultrasound

CT Scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Folate deficiency diagnostic study of choice On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Folate deficiency diagnostic study of choice

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Folate deficiency diagnostic study of choice

CDC on Folate deficiency diagnostic study of choice

Folate deficiency diagnostic study of choice in the news

Blogs on Folate deficiency diagnostic study of choice

Directions to Hospitals Treating Folate deficiency

Risk calculators and risk factors for Folate deficiency diagnostic study of choice

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency.

Diagnostic Study of Choice

Study of choice

There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, [1] but Homocysteine and methylmalonic acid levels can be helpful in confirmation.Homocysteine but not methylmalonic acid is increased in folate deficiency.[2][3]

Sequence of Diagnostic Studies

The various investigations must be performed in the following order:

  • CBC
  • Peripheral smear
  • Liver function test esp. indirect biluribin
  • LDH
  • Serum folate level
  • RBC folate level
  • plasma or serum homocysteine or methylmalonic acid
  • serum Vitamin b12 level and finally
  • serum iron panel

References

  1. ↑ Snow, Christopher F. (1999). "Laboratory Diagnosis of Vitamin B12 and Folate Deficiency". Archives of Internal Medicine. 159 (12): 1289. doi:10.1001/archinte.159.12.1289. ISSN 0003-9926.
  2. ↑ Klee GG (2000). "Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate". Clin Chem. 46 (8 Pt 2): 1277–83. PMID 10926922.
  3. ↑ Devalia V, Hamilton MS, Molloy AM, British Committee for Standards in Haematology (2014). "Guidelines for the diagnosis and treatment of cobalamin and folate disorders". Br J Haematol. 166 (4): 496–513. doi:10.1111/bjh.12959. PMID 24942828.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Folate_deficiency_diagnostic_study_of_choice&oldid=1545060"