Paget's disease of the breast other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
The use of touch/scrape smears for cytological diagnosis is recommended to prevent delay in diagnosis. Mainly in patients who are reluctant to undergo other diagnostic procedures such as wedge biopsy, shave biopsy, surgical excision. A negative result does not exclude the diagnosis of Paget's disease of the breast. | The use of touch/scrape smears for cytological diagnosis is recommended to prevent delay in [[diagnosis]]. Mainly in patients who are reluctant to undergo other [[diagnostic]] [[procedures]] such as wedge [[biopsy]], shave [[biopsy]], [[surgical excision]]. A negative result does not exclude the [[diagnosis]] of Paget's disease of the breast. [[In vivo]] reflectance confocal [[microscopy]] allows visualization of the upper layers of the [[skin]] at a [[cellular resolution]], may also assist in the early [[diagnosis]] of Paget's disease in reluctant patients. | ||
==Other Diasgnostic Findings== | ==Other Diasgnostic Findings== | ||
===Cytology=== | ===Cytology=== | ||
*The use of touch/scrape smears for cytological diagnosis is recommended to prevent delay in diagnosis. | *The use of touch/scrape smears for [[Cytology|cytological]] [[diagnosis]] is recommended to prevent delay in [[diagnosis]]. | ||
*Mainly in patients who are reluctant to undergo other diagnostic procedures such as wedge biopsy, shave biopsy, surgical excision. | *Mainly in patients who are reluctant to undergo other [[diagnostic]] [[procedures]] such as wedge [[biopsy]], shave [[biopsy]], surgical excision. | ||
*Due to the difficulty in differentiating Paget's disease from inflammatory skin conditions or squamous neoplasia on cytology, a biopsy of the nipple and areola is generally preferred for definitive diagnosis. | *Due to the difficulty in differentiating Paget's disease from [[inflammatory]] [[skin]] conditions or [[Squamous cell carcinoma of the skin|squamous neoplasia]] on [[cytology]], a [[biopsy]] of the [[nipple]] and areola is generally preferred for definitive [[diagnosis]]. | ||
*Cytology of skin scrapings many time display the presence of: | *[[Cytology]] of [[skin]] scrapings many time display the presence of: | ||
:*Single malignant cells with vacuolated cytoplasm and eccentric nuclei | :*Single [[malignant]] [[cells]] with [[Vacuole|vacuolated]] [[cytoplasm]] and [[eccentric]] [[nuclei]] | ||
:*Three dimensional cell aggregates | :*Three dimensional [[cell]] aggregates | ||
:*Acinar groups consistent with glandular differentiation | :*[[Acinar]] groups consistent with [[glandular]] differentiation | ||
*A negative result does not exclude the diagnosis of Paget's disease of the breast.<ref name="pmid7529588">{{cite journal |vauthors=Lucarotti ME, Dunn JM, Webb AJ |title=Scrape cytology in the diagnosis of Paget's disease of the breast |journal=Cytopathology |volume=5 |issue=5 |pages=301–5 |date=October 1994 |pmid=7529588 |doi= |url=}}</ref><ref name="pmid8390930">{{cite journal |vauthors=Samarasinghe D, Frost F, Sterrett G, Whitaker D, Ingram D, Sheiner H |title=Cytological diagnosis of Paget's disease of the nipple by scrape smears: a report of five cases |journal=Diagn. Cytopathol. |volume=9 |issue=3 |pages=291–5 |date=1993 |pmid=8390930 |doi= |url=}}</ref> | *A negative result does not exclude the [[diagnosis]] of Paget's disease of the breast.<ref name="pmid7529588">{{cite journal |vauthors=Lucarotti ME, Dunn JM, Webb AJ |title=Scrape cytology in the diagnosis of Paget's disease of the breast |journal=Cytopathology |volume=5 |issue=5 |pages=301–5 |date=October 1994 |pmid=7529588 |doi= |url=}}</ref><ref name="pmid8390930">{{cite journal |vauthors=Samarasinghe D, Frost F, Sterrett G, Whitaker D, Ingram D, Sheiner H |title=Cytological diagnosis of Paget's disease of the nipple by scrape smears: a report of five cases |journal=Diagn. Cytopathol. |volume=9 |issue=3 |pages=291–5 |date=1993 |pmid=8390930 |doi= |url=}}</ref> | ||
===In vivo reflectance confocal microscopy=== | ===In vivo reflectance confocal microscopy=== | ||
In vivo reflectance confocal microscopy allows visualization of the upper layers of the skin at a cellular resolution, may also assist in the early diagnosis of Paget's disease in reluctant patients. | [[In vivo]] reflectance confocal [[microscopy]] allows visualization of the upper layers of the [[skin]] at a [[cellular resolution]], may also assist in the early [[diagnosis]] of Paget's disease in reluctant patients. | ||
Latest revision as of 18:18, 14 March 2019
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Paget's disease of the breast Microchapters |
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Differentiating Paget's disease of the breast from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]
Overview
The use of touch/scrape smears for cytological diagnosis is recommended to prevent delay in diagnosis. Mainly in patients who are reluctant to undergo other diagnostic procedures such as wedge biopsy, shave biopsy, surgical excision. A negative result does not exclude the diagnosis of Paget's disease of the breast. In vivo reflectance confocal microscopy allows visualization of the upper layers of the skin at a cellular resolution, may also assist in the early diagnosis of Paget's disease in reluctant patients.
Other Diasgnostic Findings
Cytology
- The use of touch/scrape smears for cytological diagnosis is recommended to prevent delay in diagnosis.
- Mainly in patients who are reluctant to undergo other diagnostic procedures such as wedge biopsy, shave biopsy, surgical excision.
- Due to the difficulty in differentiating Paget's disease from inflammatory skin conditions or squamous neoplasia on cytology, a biopsy of the nipple and areola is generally preferred for definitive diagnosis.
- Cytology of skin scrapings many time display the presence of:
In vivo reflectance confocal microscopy
In vivo reflectance confocal microscopy allows visualization of the upper layers of the skin at a cellular resolution, may also assist in the early diagnosis of Paget's disease in reluctant patients.
References
- ↑ Lucarotti ME, Dunn JM, Webb AJ (October 1994). "Scrape cytology in the diagnosis of Paget's disease of the breast". Cytopathology. 5 (5): 301–5. PMID 7529588.
- ↑ Samarasinghe D, Frost F, Sterrett G, Whitaker D, Ingram D, Sheiner H (1993). "Cytological diagnosis of Paget's disease of the nipple by scrape smears: a report of five cases". Diagn. Cytopathol. 9 (3): 291–5. PMID 8390930.