Pseudomyxoma peritonei causes: Difference between revisions

Jump to navigation Jump to search
No edit summary
 
(5 intermediate revisions by one other user not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Pseudomyxoma peritonei}}
{{Pseudomyxoma peritonei}}
{{CMG}}{{AE}}{{PSD}}
{{CMG}}{{AE}}{{Nnasiri}}{{PSD}}
==Overview==
==Overview==
Pseudomyxoma peritonei is caused by a pre-existing intraperitoneal mucinous neoplasm. The ''K-Ras'' and ''p53'' genes may be involved in the oncogenesis.
Pseudomyxoma peritonei is a rare disease caused by a pre-existing [[intraperitoneal]] [[mucinous]] [[neoplasm]], accumulation of fluids in [[abdominal]] cavity causes mass impact on vital [[Organ (anatomy)|organs]] such as the [[spleen]], [[kidney]], and [[pancreas]]. The pathology and causes of pseudomyxoma peritonei are poorly understood. It is shown in some studies that the ''[[K-Ras]]'' and ''[[p53]]'' genes may be involved in the [[oncogenesis]].
 
==Causes==
==Causes==


*Studies have shown and supported that pseudomyxoma peritonei arises from primary appendiceal neoplasm rather than ovarian or colon origin.<ref name="pmid22718846">{{cite journal |vauthors=Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B |title=Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases |journal=J. Clin. Pathol. |volume=65 |issue=10 |pages=919–23 |date=October 2012 |pmid=22718846 |doi=10.1136/jclinpath-2012-200843 |url=}}</ref>
*Studies have shown and supported that pseudomyxoma peritonei arises from primary [[Appendiceal cancers|appendiceal neoplasm]] rather than [[ovarian]] or [[colon]].<ref name="pmid22718846">{{cite journal |vauthors=Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B |title=Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases |journal=J. Clin. Pathol. |volume=65 |issue=10 |pages=919–23 |date=October 2012 |pmid=22718846 |doi=10.1136/jclinpath-2012-200843 |url=}}</ref>
*The primary tumor appears to arise from the [[MUC2]] expressing [[goblet cell]]s and most commonly from these cells in the appendix. <ref name="pmid12163380">{{cite journal |vauthors=O'Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH |title=Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells |journal=Am. J. Pathol. |volume=161 |issue=2 |pages=551–64 |date=August 2002 |pmid=12163380 |doi=10.1016/S0002-9440(10)64211-3 |url=}}</ref>
*The primary [[tumor]] appears to arise from the [[MUC2]] expressing [[goblet cell]]s and most commonly from these cells in the [[appendix]].<ref name="pmid12163380">{{cite journal |vauthors=O'Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH |title=Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells |journal=Am. J. Pathol. |volume=161 |issue=2 |pages=551–64 |date=August 2002 |pmid=12163380 |doi=10.1016/S0002-9440(10)64211-3 |url=}}</ref>
*The K-Ras and ''[[p53]]'' genes may be involved in the oncogenesis, it was shown in studies that overexpression of p53 is in correlation with female sex, higher-grade disease, and worse survival. <ref name="pmid23199549">{{cite journal |vauthors=Shetty S, Thomas P, Ramanan B, Sharma P, Govindarajan V, Loggie B |title=Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis |journal=J. Surg. Res. |volume=180 |issue=1 |pages=97–103 |date=March 2013 |pmid=23199549 |doi=10.1016/j.jss.2012.10.053 |url=}}</ref>
*The K-Ras and ''[[p53]]'' [[Gene|genes]] may be involved in the [[oncogenesis]]. It was shown in studies that [[overexpression]] of [[p53]] was in correlation with female sex, highe-grade disease, and worse [[Survival rate|survival]].<ref name="pmid23199549">{{cite journal |vauthors=Shetty S, Thomas P, Ramanan B, Sharma P, Govindarajan V, Loggie B |title=Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis |journal=J. Surg. Res. |volume=180 |issue=1 |pages=97–103 |date=March 2013 |pmid=23199549 |doi=10.1016/j.jss.2012.10.053 |url=}}</ref>
*While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas, other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several [[mucinous]] tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).<ref name="Jacquemin_2005">{{cite journal |author=Jacquemin G, Laloux P |title=Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases |journal=Acta Chir Belg |volume=105 |issue=2 |pages=127–33 |year=2005 |pmid=15906901}}</ref>


== References ==
== References ==

Latest revision as of 20:33, 1 April 2019

Pseudomyxoma peritonei Microchapters

Home

Patient Information

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Pseudomyxoma peritonei from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Pseudomyxoma peritonei causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Pseudomyxoma peritonei causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Pseudomyxoma peritonei causes

CDC on Pseudomyxoma peritonei causes

Pseudomyxoma peritonei causes in the news

Blogs on Pseudomyxoma peritonei causes

Directions to Hospitals Treating Pseudomyxoma peritonei

Risk calculators and risk factors for Pseudomyxoma peritonei causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]Parminder Dhingra, M.D. [3]

Overview

Pseudomyxoma peritonei is a rare disease caused by a pre-existing intraperitoneal mucinous neoplasm, accumulation of fluids in abdominal cavity causes mass impact on vital organs such as the spleen, kidney, and pancreas. The pathology and causes of pseudomyxoma peritonei are poorly understood. It is shown in some studies that the K-Ras and p53 genes may be involved in the oncogenesis.

Causes

References

  1. Carr NJ, Finch J, Ilesley IC, Chandrakumaran K, Mohamed F, Mirnezami A, Cecil T, Moran B (October 2012). "Pathology and prognosis in pseudomyxoma peritonei: a review of 274 cases". J. Clin. Pathol. 65 (10): 919–23. doi:10.1136/jclinpath-2012-200843. PMID 22718846.
  2. O'Connell JT, Tomlinson JS, Roberts AA, McGonigle KF, Barsky SH (August 2002). "Pseudomyxoma peritonei is a disease of MUC2-expressing goblet cells". Am. J. Pathol. 161 (2): 551–64. doi:10.1016/S0002-9440(10)64211-3. PMID 12163380.
  3. Shetty S, Thomas P, Ramanan B, Sharma P, Govindarajan V, Loggie B (March 2013). "Kras mutations and p53 overexpression in pseudomyxoma peritonei: association with phenotype and prognosis". J. Surg. Res. 180 (1): 97–103. doi:10.1016/j.jss.2012.10.053. PMID 23199549.


Template:WikiDoc Sources