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__NOTOC__
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{{Pseudomyxoma peritonei}}
{{Pseudomyxoma peritonei}}
{{CMG}}{{AE}}{{PSD}}
{{CMG}}{{AE}}{{Nnasiri}}{{PSD}}
==Overview==
==Overview==
Symptoms of pseudomyxoma peritonei include [[abdominal pain]], [[bloating]], [[abdominal distention]], weight changes, and [[infertility]].
==History==
The median age of diagnosis for pseudomyxoma peritonei is 50 years of age. It is usually found incidentally in patients undergoing [[abdominal]] surgery or [[imaging]] for other medical conditions, most [[Patient|patients]] are diagnosed with advanced disease due to non specific symptoms of pseudomyxoma peritonei. The clinical presentation of the disease is dependent on the progression of the disease, [[tumor]]<nowiki/>s with [[Appendiceal cancers|appendiceal]] origin typically presents with [[appendicitis]]-like symptoms or if there is [[ovarian]] origin, it may present as a [[pelvic]] [[mass]] due to its compression impact on internal [[Organ (anatomy)|organs]]. More advanced disease may present with [[abdominal]] [[distension]], [[bowel obstruction]], and [[ascites]].<ref name="pmid17511043">{{cite journal |vauthors=Dixit A, Robertson JH, Mudan SS, Akle C |title=Appendiceal mucocoeles and pseudomyxoma peritonei |journal=World J. Gastroenterol. |volume=13 |issue=16 |pages=2381–4 |date=April 2007 |pmid=17511043 |pmc=4147153 |doi= |url=}}</ref><ref name="pmid11044169">{{cite journal |vauthors=Esquivel J, Sugarbaker PH |title=Clinical presentation of the Pseudomyxoma peritonei syndrome |journal=Br J Surg |volume=87 |issue=10 |pages=1414–8 |date=October 2000 |pmid=11044169 |doi=10.1046/j.1365-2168.2000.01553.x |url=}}</ref><ref name="pmid7750935">{{cite journal |vauthors=Ronnett BM, Kurman RJ, Zahn CM, Shmookler BM, Jablonski KA, Kass ME, Sugarbaker PH |title=Pseudomyxoma peritonei in women: a clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential |journal=Hum. Pathol. |volume=26 |issue=5 |pages=509–24 |date=May 1995 |pmid=7750935 |doi= |url=}}</ref>


==History==
When evaluating a patient for pseudomyxoma peritonei, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough review of past medical history.


==Symptoms==
==Symptoms==
Symptoms of pseudomyxoma peritonei may include:<ref>Pseudomyxoma peritonei. Wikipedia. https://en.wikipedia.org/wiki/Pseudomyxoma_peritonei. Accessed on 20 November, 2015.</ref><ref name="AminiMasoumi-Moghaddam2014">{{cite journal|last1=Amini|first1=Afshin|last2=Masoumi-Moghaddam|first2=Samar|last3=Ehteda|first3=Anahid|last4=Morris|first4=David|title=Secreted mucins in pseudomyxoma peritonei: pathophysiological significance and potential therapeutic prospects|journal=Orphanet Journal of Rare Diseases|volume=9|issue=1|year=2014|pages=71|issn=1750-1172|doi=10.1186/1750-1172-9-71}}</ref>
Symptoms of pseudomyxoma peritonei may include:<ref name="pmid11044169">{{cite journal |vauthors=Esquivel J, Sugarbaker PH |title=Clinical presentation of the Pseudomyxoma peritonei syndrome |journal=Br J Surg |volume=87 |issue=10 |pages=1414–8 |date=October 2000 |pmid=11044169 |doi=10.1046/j.1365-2168.2000.01553.x |url=}}</ref>
* Abdominal or pelvic pain
* [[Abdominal]] or [[pelvic]] [[pain]]
* Bloating
*New-onset [[hernia]]<ref name="pmid30026907">{{cite journal |vauthors=Gomes C, Tenreiro N, Marçal A, Moreira H, Pinto B, Avelar P |title=Pseudomyxoma peritonei presenting as irreducible epigastric hernia |journal=J Surg Case Rep |volume=2018 |issue=7 |pages=rjy148 |date=July 2018 |pmid=30026907 |pmc=6044295 |doi=10.1093/jscr/rjy148 |url=}}</ref>
* Abdominal distension
* [[Bloating]]
* Weight change
* [[Abdominal distension]]
* Increased girth
* [[Weight change]]
* [[Infertility]]
* Increased [[abdominal]] girth  
* In advanced disease, increased abdominal girth and complaints of abdominal pain related to intestinal obstruction are the most presenting symptom seen in 30-50% of the PMP patients as a result of disseminated mucinous tumor and ascites classically presenting at laparotomy with jelly belly.
*[[Appendicitis]]-like [[symptoms]] in some cases<ref name="pmid17343142">{{cite journal |vauthors=Smeenk RM, Verwaal VJ, Zoetmulder FA |title=[Pseudomyxoma peritonei; a rare tumour that can be treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy] |language=Dutch; Flemish |journal=Ned Tijdschr Geneeskd |volume=151 |issue=7 |pages=418–23 |date=February 2007 |pmid=17343142 |doi= |url=}}</ref>
* In less advanced disease, local symptoms are seen in 50-80% of PMP patients without jelly belly ascites and might correspond to the site of the primary tumor, such as appendicitis-like symptoms in 25% of cases, or the location of the peritoneal implants, including lower abdominal pain, pelvic pressure and gynecological complaints in females due to the ovarian deposits of the mucinous tumor in 20-30% of the patients.
*[[Gynecological]] complaints in [[Female|females]] such as [[menstrual]] irregularity due to the [[ovarian]] deposits of the [[mucinous]] [[tumor]]
* PMP cases presenting with an ulcerated skin fistula on the right flank or a subcutaneous non tender umbilical nodule have also been reported.
*[[Subcutaneous]] non tender [[umbilical]] [[Nodule (medicine)|nodules]] have also been reported in rare cases<ref name="pmid18224368">{{cite journal |vauthors=Srinivasaiah N, Retnasingam G, Kasarneni R, Slater B |title=Pseudomyxoma peritonei: a rare presentation as an umbilical nodule |journal=Ir J Med Sci |volume=178 |issue=2 |pages=219–21 |date=June 2009 |pmid=18224368 |doi=10.1007/s11845-008-0118-2 |url=}}</ref>


== References ==
== References ==
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]Parminder Dhingra, M.D. [3]

Overview

Symptoms of pseudomyxoma peritonei include abdominal pain, bloating, abdominal distention, weight changes, and infertility.

History

The median age of diagnosis for pseudomyxoma peritonei is 50 years of age. It is usually found incidentally in patients undergoing abdominal surgery or imaging for other medical conditions, most patients are diagnosed with advanced disease due to non specific symptoms of pseudomyxoma peritonei. The clinical presentation of the disease is dependent on the progression of the disease, tumors with appendiceal origin typically presents with appendicitis-like symptoms or if there is ovarian origin, it may present as a pelvic mass due to its compression impact on internal organs. More advanced disease may present with abdominal distension, bowel obstruction, and ascites.[1][2][3]


Symptoms

Symptoms of pseudomyxoma peritonei may include:[2]

References

  1. Dixit A, Robertson JH, Mudan SS, Akle C (April 2007). "Appendiceal mucocoeles and pseudomyxoma peritonei". World J. Gastroenterol. 13 (16): 2381–4. PMC 4147153. PMID 17511043.
  2. 2.0 2.1 Esquivel J, Sugarbaker PH (October 2000). "Clinical presentation of the Pseudomyxoma peritonei syndrome". Br J Surg. 87 (10): 1414–8. doi:10.1046/j.1365-2168.2000.01553.x. PMID 11044169.
  3. Ronnett BM, Kurman RJ, Zahn CM, Shmookler BM, Jablonski KA, Kass ME, Sugarbaker PH (May 1995). "Pseudomyxoma peritonei in women: a clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential". Hum. Pathol. 26 (5): 509–24. PMID 7750935.
  4. Gomes C, Tenreiro N, Marçal A, Moreira H, Pinto B, Avelar P (July 2018). "Pseudomyxoma peritonei presenting as irreducible epigastric hernia". J Surg Case Rep. 2018 (7): rjy148. doi:10.1093/jscr/rjy148. PMC 6044295. PMID 30026907.
  5. Smeenk RM, Verwaal VJ, Zoetmulder FA (February 2007). "[Pseudomyxoma peritonei; a rare tumour that can be treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy]". Ned Tijdschr Geneeskd (in Dutch; Flemish). 151 (7): 418–23. PMID 17343142.
  6. Srinivasaiah N, Retnasingam G, Kasarneni R, Slater B (June 2009). "Pseudomyxoma peritonei: a rare presentation as an umbilical nodule". Ir J Med Sci. 178 (2): 219–21. doi:10.1007/s11845-008-0118-2. PMID 18224368.


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