Hairy cell leukemia history and symptoms: Difference between revisions
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{{Hairy cell leukemia}} | {{Hairy cell leukemia}} | ||
{{CMG}} {{AE}}{{HL}} | {{CMG}}; {{AE}} {{VKG}}, {{HL}} | ||
==Overview== | ==Overview== | ||
A positive history of [[splenomegaly]] or [[cytopenias]] is suggestive of [[hairy cell leukemia]]. The most common symptoms of [[hairy cell leukemia]] include [[weakness]], [[fatigue]], [[gingival bleeding]], [[epistaxis]] and [[menorrhagia]]. | |||
==History== | ==History and Symptoms== | ||
==Symptoms== | === History === | ||
* | * When evaluating a patient for [[hairy cell leukemia]], you should take a detailed history of the [[Chief complaint|presenting symptom]] (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below:<ref>{{cite journal|title=How I diagnose and manage individuals at risk for inherited myeloid malignancies|journal=Blood|volume=128|issue=14|year=2016|pages=1800–1813|issn=0006-4971|doi=10.1182/blood-2016-05-670240}}</ref> | ||
** Review occupational history related to sawdust exposure | |||
** Review any exposure to [[Radiation|radiations]] | |||
** Review any exposure to [[herbicides]] or [[diesel]] | |||
=== Common Symptoms === | |||
* Common symptoms of [[hairy cell leukemia]] include:<ref name="pmid717940">{{cite journal |vauthors=Golomb HM, Catovsky D, Golde DW |title=Hairy cell leukemia: a clinical review based on 71 cases |journal=Ann. Intern. Med. |volume=89 |issue=5 Pt 1 |pages=677–83 |date=November 1978 |pmid=717940 |doi= |url=}}</ref><ref name="pmid267883822">{{cite journal |vauthors=Yonal-Hindilerden I, Hindilerden F, Bulut-Dereli S, Yıldız E, Dogan IO, Nalcaci M |title=Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature |journal=Case Rep Hematol |volume=2015 |issue= |pages=803921 |date=2015 |pmid=26788382 |pmc=4695657 |doi=10.1155/2015/803921 |url=}}</ref><ref name="pmid7519510">{{cite journal |vauthors=Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V |title=Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia |journal=Leuk. Lymphoma |volume=13 |issue=3-4 |pages=307–16 |date=April 1994 |pmid=7519510 |doi=10.3109/10428199409056295 |url=}}</ref><ref name="pmid6733679">{{cite journal |vauthors=Westbrook CA, Groopman JE, Golde DW |title=Hairy cell leukemia. Disease pattern and prognosis |journal=Cancer |volume=54 |issue=3 |pages=500–6 |date=August 1984 |pmid=6733679 |doi= |url=}}</ref> | |||
** [[Fever]] | |||
:* Early satiety | ** [[Abdominal]] fullness | ||
** [[Splenomegaly]] | |||
** [[Night sweat]]s | |||
** [[Fatigue]] | |||
** Easy [[bruising]] or [[bleeding]] | |||
** Generalized weakness | |||
** [[Weight loss]] | |||
** Recurrent [[infection]]s | |||
=== Less Common Symptoms === | |||
* Less common symptoms of [[hairy cell leukemia]] include:<ref name="pmid26788382">{{cite journal |vauthors=Yonal-Hindilerden I, Hindilerden F, Bulut-Dereli S, Yıldız E, Dogan IO, Nalcaci M |title=Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature |journal=Case Rep Hematol |volume=2015 |issue= |pages=803921 |date=2015 |pmid=26788382 |pmc=4695657 |doi=10.1155/2015/803921 |url=}}</ref> | |||
** [[Gingival bleeding]] | |||
** [[Epistaxis]] | |||
** Early [[satiety]] | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2], Haytham Allaham, M.D. [3]
Overview
A positive history of splenomegaly or cytopenias is suggestive of hairy cell leukemia. The most common symptoms of hairy cell leukemia include weakness, fatigue, gingival bleeding, epistaxis and menorrhagia.
History and Symptoms
History
- When evaluating a patient for hairy cell leukemia, you should take a detailed history of the presenting symptom (duration, onset, progression), other associated symptoms, and a thorough medication review. Other specific areas of focus when obtaining the history are outlined below:[1]
- Review occupational history related to sawdust exposure
- Review any exposure to radiations
- Review any exposure to herbicides or diesel
Common Symptoms
- Common symptoms of hairy cell leukemia include:[2][3][4][5]
- Fever
- Abdominal fullness
- Splenomegaly
- Night sweats
- Fatigue
- Easy bruising or bleeding
- Generalized weakness
- Weight loss
- Recurrent infections
Less Common Symptoms
- Less common symptoms of hairy cell leukemia include:[6]
References
- ↑ "How I diagnose and manage individuals at risk for inherited myeloid malignancies". Blood. 128 (14): 1800–1813. 2016. doi:10.1182/blood-2016-05-670240. ISSN 0006-4971.
- ↑ Golomb HM, Catovsky D, Golde DW (November 1978). "Hairy cell leukemia: a clinical review based on 71 cases". Ann. Intern. Med. 89 (5 Pt 1): 677–83. PMID 717940.
- ↑ Yonal-Hindilerden I, Hindilerden F, Bulut-Dereli S, Yıldız E, Dogan IO, Nalcaci M (2015). "Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature". Case Rep Hematol. 2015: 803921. doi:10.1155/2015/803921. PMC 4695657. PMID 26788382.
- ↑ Frassoldati A, Lamparelli T, Federico M, Annino L, Capnist G, Pagnucco G, Dini E, Resegotti L, Damasio EE, Silingardi V (April 1994). "Hairy cell leukemia: a clinical review based on 725 cases of the Italian Cooperative Group (ICGHCL). Italian Cooperative Group for Hairy Cell Leukemia". Leuk. Lymphoma. 13 (3–4): 307–16. doi:10.3109/10428199409056295. PMID 7519510.
- ↑ Westbrook CA, Groopman JE, Golde DW (August 1984). "Hairy cell leukemia. Disease pattern and prognosis". Cancer. 54 (3): 500–6. PMID 6733679.
- ↑ Yonal-Hindilerden I, Hindilerden F, Bulut-Dereli S, Yıldız E, Dogan IO, Nalcaci M (2015). "Hairy Cell Leukemia Presenting with Isolated Skeletal Involvement Successfully Treated by Radiation Therapy and Cladribine: A Case Report and Review of the Literature". Case Rep Hematol. 2015: 803921. doi:10.1155/2015/803921. PMC 4695657. PMID 26788382.