Testicular cancer classification: Difference between revisions
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{{CMG}}; {{AE}} {{G.D.}}, {{SC}} | {{CMG}}; {{AE}} {{G.D.}}, {{SC}} | ||
==Overview== | ==Overview== | ||
Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into six subtypes: [[germ cell tumors]], sex-cord stromal tumors, tumors containing both germ cell and sex-cord stromal elements, miscellaneous tumors of the testis, hematolymphoid tumors, and tumors of collecting duct and rete testis. | Testicular cancer is a very rare type of [[Cancer (disease)|cancer]]. Based on the [[histopathological]] features, testicular cancer may be classified into six subtypes: [[germ cell tumors]], [[Sex (activity)|sex]]-[[cord]] [[stromal]] [[tumors]], [[tumors]] containing both [[germ cell]] and [[Sex (activity)|sex]]-[[cord]] [[stromal]] elements, miscellaneous [[tumors]] of the [[testis]], hematolymphoid [[tumors]], and [[tumors]] of [[collecting duct]] and [[rete testis]]. | ||
==Classification== | ==Classification== | ||
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'''WHO''' classifies testicular tumors as follows:<ref name="pmid27747907">{{cite journal |vauthors=Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM |title=The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel |journal=Histopathology |volume=70 |issue=3 |pages=335–346 |date=February 2017 |pmid=27747907 |doi=10.1111/his.13102 |url=}}</ref><ref name="pmid26935559">{{cite journal |vauthors=Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM |title=The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours |journal=Eur. Urol. |volume=70 |issue=1 |pages=93–105 |date=July 2016 |pmid=26935559 |doi=10.1016/j.eururo.2016.02.029 |url=}}</ref> | '''WHO''' classifies testicular tumors as follows:<ref name="pmid27747907">{{cite journal |vauthors=Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM |title=The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel |journal=Histopathology |volume=70 |issue=3 |pages=335–346 |date=February 2017 |pmid=27747907 |doi=10.1111/his.13102 |url=}}</ref><ref name="pmid26935559">{{cite journal |vauthors=Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM |title=The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours |journal=Eur. Urol. |volume=70 |issue=1 |pages=93–105 |date=July 2016 |pmid=26935559 |doi=10.1016/j.eururo.2016.02.029 |url=}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
| | |- style="vertical-align:top;" | ||
! colspan="6" style="background:#4479BA; color: #FFFFFF;" align="center" + |Testicular Cancer | ! colspan="6" style="background:#4479BA; color: #FFFFFF;" align="center" + |Testicular Cancer | ||
|- | |- | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Germ cell tumors | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Germ cell tumors | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Sex-cord stromal tumors | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Sex-cord stromal tumors | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Miscellaneous tumors of the testis | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Miscellaneous tumors of the testis | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Hematolymphoid tumors | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Hematolymphoid tumors | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Tumors of collecting duct and rete testis | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Tumors of collecting duct and rete testis | ||
|- | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Tumors containing both germ cell and sex-cord stromal elements | ||
|'''Germ cell tumors derived from germ cell neoplasia in situ:''' | |- style="vertical-align:top;" | ||
* Non-invasive germ cell neoplasia | |'''[[Germ cell tumors]] derived from [[Germ cell neoplasm|germ cell neoplasia]] [[in situ]]:''' | ||
**Germ cell neoplasia in situ | * Non-invasive [[germ cell]] [[neoplasia]] | ||
**Specific forms of intratubular germ cell tumor neoplasia | **[[Germ cell]] [[neoplasia]] [[in situ]] | ||
* Tumors of a single histological type (pure forms) | **Specific forms of intratubular [[germ cell]] tumor [[neoplasia]] | ||
**Seminoma | * [[Tumor|Tumors]] of a single [[histological]] type (pure forms) | ||
**Seminoma with syncytiotrophoblast cells | **[[Seminoma]] | ||
**Non-seminomatous germ cell tumors | **[[Seminoma|Seminoma with syncytiotrophoblast cells]] | ||
**Embryonal carcinoma | **Non-seminomatous [[germ cell]] [[tumors]] | ||
** | **[[Embryonal carcinoma]] | ||
**Trophoblastic tumors | **[[Yolk sac tumor]], postpubertal-type | ||
***Choriocarcinoma | **[[Trophoblastic|Trophoblastic tumors]] | ||
***Non-choriocarcinomatous trophoblastic tumors | ***[[Choriocarcinoma]] | ||
***Placental site trophoblastic tumor | ***Non-choriocarcinomatous [[Trophoblastic|trophoblastic tumors]] | ||
***Epitheliol trophoblastic tumor | ***[[Placental]] site [[trophoblastic]] [[tumor]] | ||
***Cystic trophoblastic tumor | ***Epitheliol [[Trophoblastic|trophoblastic tumor]] | ||
**Teratoma, postpubertal-type | ***[[Cystic]] [[trophoblastic]] tumor | ||
**Teratoma with somatic-type | **[[Teratoma]], postpubertal-type | ||
*Non-seminomatous germ cell type tumor of more than one histological type | **[[Teratoma]] with somatic-type | ||
**Mixed germ cell tumors | *Non-seminomatous [[Germ cell tumor|germ cell type tumor]] of more than one [[histological]] type | ||
*Germ cell tumors of unknown type | **[[Germ cell tumors|Mixed germ cell tumors]] | ||
**Regressed germ cell tumors | *[[Germ cell tumors]] of unknown type | ||
'''Germ cell tumors unrelated to germ cell neoplasia in situ:''' | **Regressed [[germ cell tumors]] | ||
*Spermatocytic tumor | '''[[Germ cell tumors]] unrelated to [[Germ cell neoplasm|germ cell neoplasia]] [[in situ]]:''' | ||
*Teratoma, prepubertal-type | *Spermatocytic [[tumor]] | ||
**Dermoid cyst | *[[Teratoma]], prepubertal-type | ||
**Epidermoid cyst | **[[Dermoid cyst]] | ||
**Well-differentiated neuroendocrine tumor (monodermal teratoma) | **[[Epidermoid cyst]] | ||
*Mixed teratoma and yolk sac tumor, prepubertal-type | **Well-differentiated [[neuroendocrine]] [[tumor]] ([[monodermal teratoma]]) | ||
*Yolk sac tumor, prepubertal-type | *Mixed [[teratoma]] and [[yolk sac tumor]], prepubertal-type | ||
*[[Yolk sac tumor]], prepubertal-type | |||
| | | | ||
* | *Pure [[tumors]] | ||
*[[Leydig cell tumor]] | |||
* | **[[Leydig cell tumor|Malignant leydig cell tumor]] | ||
|'''Ovarian epithelial-type tumors''' | *[[Sertoli cell|Sertoli cell tumor]] | ||
*Serous cystadenoma | **[[Malignant]] [[Sertoli cell]] [[tumor]] | ||
*Serous tumor of borderline malignancy | **[[Large cell]] calcifying [[Sertoli cell]] [[tumor]] | ||
**Intratubular large cell hyalinizing [[Sertoli cell]] [[neoplasia]] | |||
*[[Granulosa cell tumor]] | |||
**[[Granulosa cell tumor|Adult granulosa cell tumor]] | |||
**[[Granulosa cell tumor|Juvenile granulosa cell tumor]] | |||
*[[Tumors]] in the [[fibroma]]-[[thecoma]] group | |||
*Mixed and unclassified sex-[[Stromal|stromal tumors]] | |||
*Mixed [[sex cord-stromal tumor]] | |||
*Unclassified [[sex cord-stromal tumor]] | |||
|'''[[Ovarian]] epithelial-type tumors''' | |||
*[[Serous]] cystadenoma | |||
*Serous [[tumor]] of borderline [[malignancy]] | |||
*Serous cystadenocarcinoma | *Serous cystadenocarcinoma | ||
*Mucinous borderline tumor | *[[Mucinous]] borderline [[tumor]] | ||
*Mucinous cystadenocarcinoma | *Mucinous cystadenocarcinoma | ||
*Endometrioid adenocarcinoma | *[[Endometrioid tumor|Endometrioid]] [[adenocarcinoma]] | ||
*Clear cell adenocarcinoma | *[[Adenocarcinoma|Clear cell adenocarcinoma]] | ||
*Brenner tumor | *Brenner tumor | ||
'''Juvenile Xanthogranuloma''' | '''Juvenile Xanthogranuloma''' | ||
'''Hemangioma''' | '''Hemangioma''' | ||
| | | | ||
*Diffuse large B-cell lymphoma | *[[Diffuse large B-cell lymphoma]] | ||
*Follicular lymphoma, NOS | *[[Follicular lymphoma]], NOS | ||
*Extranodal NK/T-cell lymphoma, nasal type | *[[Extranodal NK-T-cell lymphoma|Extranodal]] [[Lymphoma|NK/T-cell lymphoma]], nasal type | ||
*Plasmacytoma | *[[Plasmacytoma]] | ||
*Myeloid sarcoma | *[[Myeloid]] [[sarcoma]] | ||
*Rosai-Dorfman disease | *[[Rosai-Dorfman disease]] | ||
* | | | ||
*[[Adenoma]] | |||
*[[Adenocarcinoma]] | |||
| | | | ||
* | *[[Gonadoblastoma]] | ||
|} | |} | ||
Latest revision as of 16:19, 28 May 2019
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Testicular cancer Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Testicular cancer classification On the Web |
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American Roentgen Ray Society Images of Testicular cancer classification |
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Risk calculators and risk factors for Testicular cancer classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]
Overview
Testicular cancer is a very rare type of cancer. Based on the histopathological features, testicular cancer may be classified into six subtypes: germ cell tumors, sex-cord stromal tumors, tumors containing both germ cell and sex-cord stromal elements, miscellaneous tumors of the testis, hematolymphoid tumors, and tumors of collecting duct and rete testis.
Classification
WHO Classification of testicular Tumors
WHO classifies testicular tumors as follows:[1][2]
| Testicular Cancer | |||||
|---|---|---|---|---|---|
| Germ cell tumors | Sex-cord stromal tumors | Miscellaneous tumors of the testis | Hematolymphoid tumors | Tumors of collecting duct and rete testis | Tumors containing both germ cell and sex-cord stromal elements |
Germ cell tumors derived from germ cell neoplasia in situ:
Germ cell tumors unrelated to germ cell neoplasia in situ:
|
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Ovarian epithelial-type tumors
Juvenile Xanthogranuloma Hemangioma |
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References
- ↑ Williamson SR, Delahunt B, Magi-Galluzzi C, Algaba F, Egevad L, Ulbright TM, Tickoo SK, Srigley JR, Epstein JI, Berney DM (February 2017). "The World Health Organization 2016 classification of testicular germ cell tumours: a review and update from the International Society of Urological Pathology Testis Consultation Panel". Histopathology. 70 (3): 335–346. doi:10.1111/his.13102. PMID 27747907.
- ↑ Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM (July 2016). "The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours". Eur. Urol. 70 (1): 93–105. doi:10.1016/j.eururo.2016.02.029. PMID 26935559.