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__NOTOC__
{{Lung cancer}}
{{Lung cancer}}
{{CMG}}; '''Assistant Editor(s)-In-Chief:''' [[User:Michael Maddaleni|Michael Maddaleni, B.S.]]
{{CMG}}; {{AE}} {{SH}} {{YD}}
 


==Overview==
==Overview==
Today, lung cancer is one of the leading causes of death worldwide, killing over 1 million people per year but it was not always that way. Approximately 150 years ago, lung cancer was actually a very rare disease. At the Institute of Pathology of the University of Dresden in Germany, lung cancer represented only 1% of all cancers seen at autopsy.<ref name="urlA Short History of Lung Cancer">{{cite web |url=http://toxsci.oxfordjournals.org/content/64/1/4.full |title=A Short History of Lung Cancer |format= |work= |accessdate=2011-12-05}}</ref>
Prior to the introduction of [[cigarette]] [[smoking]] and industrial [[carcinogens]], lung cancer was thought to be a [[rare disease]]. Of all the [[tumors]] detected on [[autopsy]], lung cancer accounted for only 1% of [[cancers]] in the 1800s. The majority of cases of lung cancer were associated with occupational hazards due to [[radon]] exposure. The association between lung cancer and [[smoking]] was not defined until the mid-20th century.


Lung cancer steadily rose from this point on and in 1918 the percentage had risen to nearly 10% and by 1927, it represented more than 14% of all cancers. Around this time period, the disease had a life expectancy from about 6 months to 2 years and in most cases, the afflicted individual had had long term chronic bronchitis.<ref name="urlA Short History of Lung Cancer">{{cite web |url=http://toxsci.oxfordjournals.org/content/64/1/4.full |title=A Short History of Lung Cancer |format= |work= |accessdate=2011-12-05}}</ref>
==Historical Perspective==
*The historical data on lung cancer is described below:<ref name="pmid11606795">{{cite journal |author=Witschi H |title=A short history of lung cancer |journal=[[Toxicological Sciences : an Official Journal of the Society of Toxicology]] |volume=64 |issue=1 |pages=4–6 |year=2001 |month=November |pmid=11606795 |doi= |url=http://toxsci.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=11606795 |accessdate=2011-12-09}}</ref><ref name="pmid10413421">{{cite journal |vauthors=Hecht SS |title=Tobacco smoke carcinogens and lung cancer |journal=J. Natl. Cancer Inst. |volume=91 |issue=14 |pages=1194–210 |year=1999 |pmid=10413421 |doi= |url=}}</ref><ref>Kluger, R. (1996). Ashes to ashes: America's hundred-year cigarette war, the public health, and the unabashed triumph of Philip Morris. New York: Alfred A. Knopf.</ref><ref>{{cite book | last = Proctor | first = Robert | title = The Nazi war on cancer | publisher = Princeton University Press | location = Princeton, N.J. Oxford | year = 2000 | isbn = 978-0691070513 }}</ref><ref name="Morabia2012">{{cite journal|last1=Morabia|first1=Alfredo|title=Quality, originality, and significance of the 1939 “Tobacco consumption and lung carcinoma” article by Mueller, including translation of a section of the paper|journal=Preventive Medicine|volume=55|issue=3|year=2012|pages=171–177|issn=00917435|doi=10.1016/j.ypmed.2012.05.008}}</ref><ref>Mueller F. Tabakmissbrauch und Lungencarcinom. Z. Krebsforsch. 1939;49:57–85.</ref><ref>Wynder, E. L. (1994). Prevention and cessation of tobacco use: Obstacles and challenges. J. Smoking-Related Dis. 5(Suppl. 1), 3–8.</ref><ref>Hanspeter Witschi
ITEH and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616</ref>
*The majority of cases of lung cancer were associated with occupational hazards. Death among miners was reported to be caused by ''Bergkrankheit'' ([[mountain sickness]]).
*During World War 1, [[cigarette smoking]] gained popularity because the soldiers used to [[Smoking|smoke]] in trenches to relieve [[Stress (medicine)|stress]], so did the civilians and the women at home. General John J. (“Black Jack”) Pershing reportedly stated: “You ask me what it is we need to win this war. I answer [[tobacco]] as much as bullets.”
*In 1924, [[radon]] [[gas]] was first reported to be a prominent cause of lung cancer among miners.
*In 1929, Fritz Lickint, a German [[physician]], published a paper and suggested that lung cancer [[Patient|patients]] were likely to be [[Smoking|smokers]].
*In 1929, Fritz Lickint launched an anti-[[tobacco]] campaign in Germany.
*In the 1930s, [[Clinician|clinicians]] started suspecting the association between [[cigarette]] [[smoking]] and lung cancer due to an increased number of cases.
*The association between lung cancer and [[smoking]] was not defined until the mid-20th century. The first reports between lung cancer and [[smoking]] were often [[Confounding|confounded]] by gender, given that [[men]] were more likely to be [[Smoking|smokers]] compared to [[Female|women]].
*In the 1950s, Doll and Hill in England provided additional corroboration for a causal association between [[smoking]] and lung cancer.
*In the 1950s, Cuyler Hammond and Ernest Wynder in the U.S provided additional corroboration for a causal association between [[smoking]] and lung cancer.
*In 1961, the first case of [[Adenocarcinoma of the lung|adenocarcinoma]] of the [[lung]] was reported.
*The 1969, Springer Handbook of Special Pathology is considered to be the landmark [[publication]] that highlighted the role of [[smoking]] in the development of lung cancer in over 25 pages.
*In 1969, the first [[surgeon]] general warning suggesting [[cigarette smoking]] to be a hazard for lung cancer was issued.
*In the 1980s, [[cisplatin]]-based [[chemotherapy]] emerged and demonstrated modest [[efficacy]] in the reduction of [[tumor]] related [[symptoms]] and the improvement of [[quality of life]].


==History by Cause==
==References==
{{reflist|2}}
{{Tumors}}


===Smoking===
[[Category:Disease]]
When lung cancer started to become prevalent, tobacco use was not one of the suspected culprits. In the 1930 edition of the ''Springer Handbook of Special Pathology'' [[smoking]] was briefly mentioned in 1 or 2 sentences as a possible cause. It did point out that many investigations had shown no correlation between smoking and lung cancer.<ref name="urlA Short History of Lung Cancer">{{cite web |url=http://toxsci.oxfordjournals.org/content/64/1/4.full |title=A Short History of Lung Cancer |format= |work= |accessdate=2011-12-05}}</ref> Although the majority of countries didn't suspect the chemicals in smoke as [[carcinogens]], a German physician, Fritz Lickint published a paper in which he said that lung cancer patients are likely to be smokers. Lickint went on an anti-smoking crusade and it actually caught on relatively strongly in Germany.<ref name="urlA Short History of Lung Cancer">{{cite web |url=http://toxsci.oxfordjournals.org/content/64/1/4.full |title=A Short History of Lung Cancer |format= |work= |accessdate=2011-12-05}}</ref>
[[Category:Types of cancer]]
[[Category:Pulmonology]]
[[Category:Lung cancer]]


By 1969, a new edition of the handbook had 25 detailed pages of the role of cigarette smoking and lung cancer. Contrary to popular belief, between 1930 and 1969 (when the new edition of the handbook was released) there actually were actually studies done determining the detriments of [[smoking]]. A case control study in Germany in 1940 was published in which the author stated that “the extraordinary rise in tobacco use was the single most important cause of the rising incidence of lung cancer” (Müller).<ref name="urlA Short History of Lung Cancer">{{cite web |url=http://toxsci.oxfordjournals.org/content/64/1/4.full |title=A Short History of Lung Cancer |format= |work= |accessdate=2011-12-05}}</ref> Also, in 1943, the German Institute for Tobacco Hazards Research released a study which showed that out of 109 lung cancer patients, only 3 of them were non-smokers. Although studies like these existed, it took quite some time for the connection between lung cancer and smoking to catch on.
{{WH}}
 
{{WS}}
===Radon===
[[Category:Up-To-Date]]
As early as 1500, attention was called to a certain condition that was not known at the time to be anything cancerous. In two German regions, there were successful mines of silver, nickel, cobalt, bismuth, and [[arsenic]]. 60 to 80% of all the miners in these mines died from a disease they called ''Bergkrankheit'' (mountain sickness).<ref name="urlA Short History of Lung Cancer">{{cite web |url=http://toxsci.oxfordjournals.org/content/64/1/4.full |title=A Short History of Lung Cancer |format= |work= |accessdate=2011-12-05}}</ref> Lung cancer in miners became considered an occupational hazard. It was thought that the chemical constituents, such as [[arsenic]], were the cause of this deadly disease but it was also suspected that so called ''[[radium]] emanation'' was the main cause. In 1924, measurements published by a German physics journal confirmed that there were very high concentrations of [[radon gas]] in the mines. Some of them had concentrations as high as 18,000 picocuries per liter.<ref name="urlA Short History of Lung Cancer">{{cite web |url=http://toxsci.oxfordjournals.org/content/64/1/4.full |title=A Short History of Lung Cancer |format= |work= |accessdate=2011-12-05}}</ref>
[[Category:Oncology]]
 
[[Category:Medicine]]
==References==
[[Category:Pulmonology]]
{{reflist|2}}
[[Category:Surgery]]

Latest revision as of 17:41, 2 July 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dildar Hussain, MBBS [2] Yazan Daaboul, M.D.

Overview

Prior to the introduction of cigarette smoking and industrial carcinogens, lung cancer was thought to be a rare disease. Of all the tumors detected on autopsy, lung cancer accounted for only 1% of cancers in the 1800s. The majority of cases of lung cancer were associated with occupational hazards due to radon exposure. The association between lung cancer and smoking was not defined until the mid-20th century.

Historical Perspective

  • The historical data on lung cancer is described below:[1][2][3][4][5][6][7][8]
  • The majority of cases of lung cancer were associated with occupational hazards. Death among miners was reported to be caused by Bergkrankheit (mountain sickness).
  • During World War 1, cigarette smoking gained popularity because the soldiers used to smoke in trenches to relieve stress, so did the civilians and the women at home. General John J. (“Black Jack”) Pershing reportedly stated: “You ask me what it is we need to win this war. I answer tobacco as much as bullets.”
  • In 1924, radon gas was first reported to be a prominent cause of lung cancer among miners.
  • In 1929, Fritz Lickint, a German physician, published a paper and suggested that lung cancer patients were likely to be smokers.
  • In 1929, Fritz Lickint launched an anti-tobacco campaign in Germany.
  • In the 1930s, clinicians started suspecting the association between cigarette smoking and lung cancer due to an increased number of cases.
  • The association between lung cancer and smoking was not defined until the mid-20th century. The first reports between lung cancer and smoking were often confounded by gender, given that men were more likely to be smokers compared to women.
  • In the 1950s, Doll and Hill in England provided additional corroboration for a causal association between smoking and lung cancer.
  • In the 1950s, Cuyler Hammond and Ernest Wynder in the U.S provided additional corroboration for a causal association between smoking and lung cancer.
  • In 1961, the first case of adenocarcinoma of the lung was reported.
  • The 1969, Springer Handbook of Special Pathology is considered to be the landmark publication that highlighted the role of smoking in the development of lung cancer in over 25 pages.
  • In 1969, the first surgeon general warning suggesting cigarette smoking to be a hazard for lung cancer was issued.
  • In the 1980s, cisplatin-based chemotherapy emerged and demonstrated modest efficacy in the reduction of tumor related symptoms and the improvement of quality of life.

References

  1. Witschi H (2001). "A short history of lung cancer". Toxicological Sciences : an Official Journal of the Society of Toxicology. 64 (1): 4–6. PMID 11606795. Retrieved 2011-12-09. Unknown parameter |month= ignored (help)
  2. Hecht SS (1999). "Tobacco smoke carcinogens and lung cancer". J. Natl. Cancer Inst. 91 (14): 1194–210. PMID 10413421.
  3. Kluger, R. (1996). Ashes to ashes: America's hundred-year cigarette war, the public health, and the unabashed triumph of Philip Morris. New York: Alfred A. Knopf.
  4. Proctor, Robert (2000). The Nazi war on cancer. Princeton, N.J. Oxford: Princeton University Press. ISBN 978-0691070513.
  5. Morabia, Alfredo (2012). "Quality, originality, and significance of the 1939 "Tobacco consumption and lung carcinoma" article by Mueller, including translation of a section of the paper". Preventive Medicine. 55 (3): 171–177. doi:10.1016/j.ypmed.2012.05.008. ISSN 0091-7435.
  6. Mueller F. Tabakmissbrauch und Lungencarcinom. Z. Krebsforsch. 1939;49:57–85.
  7. Wynder, E. L. (1994). Prevention and cessation of tobacco use: Obstacles and challenges. J. Smoking-Related Dis. 5(Suppl. 1), 3–8.
  8. Hanspeter Witschi ITEH and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616

Template:Tumors

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