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Uveal melanoma is caused by a [[mutation]] in the [[DNA]].
Uveal melanoma is caused by a [[mutation]] in the [[DNA]].
==Causes==
==Causes==
Uveal melanoma is caused by a mutation in the DNA. These DNA mutations may be either inherited or acquired during life.
Uveal melanoma is caused by a [[mutation]] in the [[DNA]]. These [[DNA]] [[Mutation|mutations]] may be either inherited or acquired during life.<ref name="pmid21083380">{{cite journal| author=Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T et al.| title=Mutations in GNA11 in uveal melanoma. | journal=N Engl J Med | year= 2010 | volume= 363 | issue= 23 | pages= 2191-9 | pmid=21083380 | doi=10.1056/NEJMoa1000584 | pmc=PMC3107972 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21083380  }} </ref><ref name="pmid19078957">{{cite journal| author=Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM et al.| title=Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. | journal=Nature | year= 2009 | volume= 457 | issue= 7229 | pages= 599-602 | pmid=19078957 | doi=10.1038/nature07586 | pmc=PMC2696133 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19078957  }} </ref><ref name="pmid25304237">{{cite journal| author=Shoushtari AN, Carvajal RD| title=GNAQ and GNA11 mutations in uveal melanoma. | journal=Melanoma Res | year= 2014 | volume= 24 | issue= 6 | pages= 525-34 | pmid=25304237 | doi=10.1097/CMR.0000000000000121 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25304237  }} </ref>
== References ==  
== References ==  
{{Reflist|2}}
{{reflist|2}}
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[[Category:Disease]]
[[Category:Disease]]
[[Category:Ophthalmology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Ophthalmology]]
[[Category:Ophthalmology]]

Latest revision as of 14:39, 13 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Uveal melanoma is caused by a mutation in the DNA.

Causes

Uveal melanoma is caused by a mutation in the DNA. These DNA mutations may be either inherited or acquired during life.[1][2][3]

References

  1. Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T; et al. (2010). "Mutations in GNA11 in uveal melanoma". N Engl J Med. 363 (23): 2191–9. doi:10.1056/NEJMoa1000584. PMC 3107972. PMID 21083380.
  2. Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM; et al. (2009). "Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi". Nature. 457 (7229): 599–602. doi:10.1038/nature07586. PMC 2696133. PMID 19078957.
  3. Shoushtari AN, Carvajal RD (2014). "GNAQ and GNA11 mutations in uveal melanoma". Melanoma Res. 24 (6): 525–34. doi:10.1097/CMR.0000000000000121. PMID 25304237.

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