Schwannoma natural history, complications and prognosis: Difference between revisions

Jump to navigation Jump to search
(Created page with "__NOTOC__ {{Schwannoma}} {{CMG}}; {{AE}}{{M.N}} ==== Clinical presentation ==== Presentation depends on the location of the tumor (see below) but generally, symptoms are due...")
 
 
(5 intermediate revisions by the same user not shown)
Line 2: Line 2:
{{Schwannoma}}
{{Schwannoma}}
{{CMG}}; {{AE}}{{M.N}}
{{CMG}}; {{AE}}{{M.N}}
==Natural history==
More than half of all VS grow at an average of 2–4 mm/year, whereas less than 10% regress27. One study revealed that extrameatal tumors (28.9%) were more likely to grow compared to intrameatal tumors (17%) and a larger percentage of tumors grew early on after detection28. VS >2 cm are more likely to grow compared to smaller VS29–30. Growth rates of >2 mm/year are associated with decreased rates of hearing preservation compared to slower growth rates31


==== Clinical presentation ====
==== Clinical presentation ====
Presentation depends on the location of the tumor (see below) but generally, symptoms are due to local mass effect or dysfunction of the nerve they arise from.   
Presentation depends on the location of the tumor (see below) but generally, symptoms are due to local mass effect or dysfunction of the nerve they arise from. <ref name="pmid8971818">{{cite journal |vauthors=Matthies C, Samii M |title=Management of 1000 vestibular schwannomas (acoustic neuromas): clinical presentation |journal=Neurosurgery |volume=40 |issue=1 |pages=1–9; discussion 9–10 |date=January 1997 |pmid=8971818 |doi=10.1097/00006123-199701000-00001 |url=}}</ref>  


Symptoms of schwannoma depend on the location of the tumor.
Symptoms of schwannoma depend on the location of the tumor.
Line 42: Line 45:
*Intramuscular schwannoma
*Intramuscular schwannoma
:*Painless [[mass]]
:*Painless [[mass]]
==Complications==
Besides the complications that are directly produced the schwannoma itself due to it mass affect, there are many other complications that may arise post-surgical or post-radiation therapy depending on the anatomic location of the tumor. <ref name="pmid22937847">{{cite journal |vauthors=Yashar P, Zada G, Harris B, Giannotta SL |title=Extent of resection and early postoperative outcomes following removal of cystic vestibular schwannomas: surgical experience over a decade and review of the literature |journal=Neurosurg Focus |volume=33 |issue=3 |pages=E13 |date=September 2012 |pmid=22937847 |doi=10.3171/2012.7.FOCUS12206 |url=}}</ref>
==== Surgical complications: ====
* Peri-operative hemorrhage
* CSF leaks
* Infections
==Prognosis==
* Schwannomas are slow growing tumors.
* The rate of recurrence after resection is extremely low. <ref name="pmid27695564">{{cite journal |vauthors=Senapati SB, Mishra SS, Dhir MK, Patnaik A, Panigrahi S |title=Recurrence of spinal schwannoma: Is it preventable? |journal=Asian J Neurosurg |volume=11 |issue=4 |pages=451 |date=2016 |pmid=27695564 |pmc=4974985 |doi=10.4103/1793-5482.145060 |url=}}</ref>
* They almost never turn malignant.
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 01:48, 30 October 2019

Schwannoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Schwannoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Biopsy

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Schwannoma natural history, complications and prognosis On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Schwannoma natural history, complications and prognosis

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Schwannoma natural history, complications and prognosis

CDC on Schwannoma natural history, complications and prognosis

Schwannoma natural history, complications and prognosis in the news

Blogs on Schwannoma natural history, complications and prognosis

Directions to Hospitals Treating Schwannoma

Risk calculators and risk factors for Schwannoma natural history, complications and prognosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maneesha Nandimandalam, M.B.B.S.[2]

Natural history

More than half of all VS grow at an average of 2–4 mm/year, whereas less than 10% regress27. One study revealed that extrameatal tumors (28.9%) were more likely to grow compared to intrameatal tumors (17%) and a larger percentage of tumors grew early on after detection28. VS >2 cm are more likely to grow compared to smaller VS29–30. Growth rates of >2 mm/year are associated with decreased rates of hearing preservation compared to slower growth rates31

Clinical presentation

Presentation depends on the location of the tumor (see below) but generally, symptoms are due to local mass effect or dysfunction of the nerve they arise from. [1]

Symptoms of schwannoma depend on the location of the tumor.

  • Intracranial schwannoma:
  • Trigeminal schwannoma
  • Facial nerve schwannoma
  • Jugular foramen schwannoma
  • Hypoglossal schwannomas
  • Spinal schwannoma
  • Intercostal nerve schwannoma
  • Usually asymptomatic
  • Intramuscular schwannoma

Complications

Besides the complications that are directly produced the schwannoma itself due to it mass affect, there are many other complications that may arise post-surgical or post-radiation therapy depending on the anatomic location of the tumor. [2]

Surgical complications:

  • Peri-operative hemorrhage
  • CSF leaks
  • Infections

Prognosis

  • Schwannomas are slow growing tumors.
  • The rate of recurrence after resection is extremely low. [3]
  • They almost never turn malignant.

References

  1. Matthies C, Samii M (January 1997). "Management of 1000 vestibular schwannomas (acoustic neuromas): clinical presentation". Neurosurgery. 40 (1): 1–9, discussion 9–10. doi:10.1097/00006123-199701000-00001. PMID 8971818.
  2. Yashar P, Zada G, Harris B, Giannotta SL (September 2012). "Extent of resection and early postoperative outcomes following removal of cystic vestibular schwannomas: surgical experience over a decade and review of the literature". Neurosurg Focus. 33 (3): E13. doi:10.3171/2012.7.FOCUS12206. PMID 22937847.
  3. Senapati SB, Mishra SS, Dhir MK, Patnaik A, Panigrahi S (2016). "Recurrence of spinal schwannoma: Is it preventable?". Asian J Neurosurg. 11 (4): 451. doi:10.4103/1793-5482.145060. PMC 4974985. PMID 27695564.


Template:WikiDoc Sources