Secondary amyloidosis laboratory findings: Difference between revisions
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{{Secondary amyloidosis}} | {{Secondary amyloidosis}} | ||
{{CMG}}; {{AE}} {{Sahar}} | {{CMG}}; {{AE}} {{Sahar}} {{SHH}} | ||
==Overview== | ==Overview== | ||
An elevated urinary protein is suggestive of secondary amyloidosis. | An elevated [[urinary]] [[protein]] is suggestive of secondary amyloidosis. Elevated level of [[acute phase reactant]], abnormal [[liver function test]], and other findings may also be observed. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
* Laboratory findings suggestive of secondary amyloidosis vary depending on the affected organ.<ref name="PapaLachmann2018">{{cite journal|last1=Papa|first1=Riccardo|last2=Lachmann|first2=Helen J.|title=Secondary, AA, Amyloidosis|journal=Rheumatic Disease Clinics of North America|volume=44|issue=4|year=2018|pages=585–603|issn=0889857X|doi=10.1016/j.rdc.2018.06.004}}</ref> | * Laboratory findings suggestive of secondary amyloidosis vary depending on the affected [[organ]].<ref name="PapaLachmann2018">{{cite journal|last1=Papa|first1=Riccardo|last2=Lachmann|first2=Helen J.|title=Secondary, AA, Amyloidosis|journal=Rheumatic Disease Clinics of North America|volume=44|issue=4|year=2018|pages=585–603|issn=0889857X|doi=10.1016/j.rdc.2018.06.004}}</ref> | ||
* The most commonly observable finding is proteinuria, particularly nephrotic range (>3.5 g/day). | * The most commonly observable finding is [[proteinuria]], particularly [[nephrotic]] range (>3.5 g/day). | ||
* Other possible laboratory findings include:<ref name="Real de AsuaGalvan2014">{{cite journal|last1=Real de Asua|first1=Diego|last2=Galvan|first2=Jose Maria|last3=Filigghedu|first3=Maria Teresa|last4=Trujillo|first4=Davinia|last5=Costa|first5=Ramon|last6=Cadinanos|first6=Julen|title=Systemic AA amyloidosis: epidemiology, diagnosis, and management|journal=Clinical Epidemiology|year=2014|pages=369|issn=1179-1349|doi=10.2147/CLEP.S39981}}</ref> | |||
** Elevated NT-proBNP in case of [[cardiac]] involvement. | |||
** [[Alkaline phosphatase]] Value >1.5 upper limit of normal in case of [[liver]] involvement. | |||
** Elevated level of [[acute phase reactant]] due to underlying inflammatory condition. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Latest revision as of 19:34, 7 November 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sahar Memar Montazerin, M.D.[2] Shaghayegh Habibi, M.D.[3]
Overview
An elevated urinary protein is suggestive of secondary amyloidosis. Elevated level of acute phase reactant, abnormal liver function test, and other findings may also be observed.
Laboratory Findings
- Laboratory findings suggestive of secondary amyloidosis vary depending on the affected organ.[1]
- The most commonly observable finding is proteinuria, particularly nephrotic range (>3.5 g/day).
- Other possible laboratory findings include:[2]
- Elevated NT-proBNP in case of cardiac involvement.
- Alkaline phosphatase Value >1.5 upper limit of normal in case of liver involvement.
- Elevated level of acute phase reactant due to underlying inflammatory condition.
References
- ↑ Papa, Riccardo; Lachmann, Helen J. (2018). "Secondary, AA, Amyloidosis". Rheumatic Disease Clinics of North America. 44 (4): 585–603. doi:10.1016/j.rdc.2018.06.004. ISSN 0889-857X.
- ↑ Real de Asua, Diego; Galvan, Jose Maria; Filigghedu, Maria Teresa; Trujillo, Davinia; Costa, Ramon; Cadinanos, Julen (2014). "Systemic AA amyloidosis: epidemiology, diagnosis, and management". Clinical Epidemiology: 369. doi:10.2147/CLEP.S39981. ISSN 1179-1349.