Cretinism causes: Difference between revisions

Jump to navigation Jump to search
← Older edit
VisualWikitext
Aelsaiey (talk | contribs)
nocaptcha, smwadministrator, Administrators
4,616 edits
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Bot: Automated text replacement (-{{columns-list|3| +{{columns-list|)
 
(12 intermediate revisions by 3 users not shown)
Line 4: Line 4:


==Overview==
==Overview==
Cretinism may be caused by congenital causes like [[thyroid dysgenesis]] and [[ectopic]] thyroid gland. Cretinism can be caused by other causes like antithyroid medications and iodine deficiency.  
Cretinism may be caused by congenital causes like [[thyroid dysgenesis]] and [[ectopic]] [[thyroid gland]]. Cretinism may be caused by other causes like [[Antithyroid agents|antithyroid medications]] and [[iodine deficiency]].
 
==Causes==
==Causes==


Line 11: Line 12:
====Common Causes====
====Common Causes====
Primary Cretinism may be caused by:<ref name="pmid20083154">{{cite journal| author=Persani L, Calebiro D, Cordella D, Weber G, Gelmini G, Libri D et al.| title=Genetics and phenomics of hypothyroidism due to TSH resistance. | journal=Mol Cell Endocrinol | year= 2010 | volume= 322 | issue= 1-2 | pages= 72-82 | pmid=20083154 | doi=10.1016/j.mce.2010.01.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20083154  }}</ref><ref name="pmid28534114">{{cite journal| author=Wassner AJ| title=Pediatric Hypothyroidism: Diagnosis and Treatment. | journal=Paediatr Drugs | year= 2017 | volume= 19 | issue= 4 | pages= 291-301 | pmid=28534114 | doi=10.1007/s40272-017-0238-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28534114  }}</ref>
Primary Cretinism may be caused by:<ref name="pmid20083154">{{cite journal| author=Persani L, Calebiro D, Cordella D, Weber G, Gelmini G, Libri D et al.| title=Genetics and phenomics of hypothyroidism due to TSH resistance. | journal=Mol Cell Endocrinol | year= 2010 | volume= 322 | issue= 1-2 | pages= 72-82 | pmid=20083154 | doi=10.1016/j.mce.2010.01.008 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20083154  }}</ref><ref name="pmid28534114">{{cite journal| author=Wassner AJ| title=Pediatric Hypothyroidism: Diagnosis and Treatment. | journal=Paediatr Drugs | year= 2017 | volume= 19 | issue= 4 | pages= 291-301 | pmid=28534114 | doi=10.1007/s40272-017-0238-0 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28534114  }}</ref>
* Congenital causes:  
* '''Congenital causes:'''
**Thyroid dysgenesis  
**[[Thyroid dysgenesis]]
**Thyroid dyshormonogenesis  
**[[Thyroid]] [[dyshormonogenesis]]
**Ectopic thyroid  
**[[Ectopic]] [[thyroid gland]] 
*Acquired causes:
*'''Acquired causes:'''
**Autoimmune diseases
**[[Autoimmune diseases]]
**Antibodies pass placenta cause hypothyroidism  
**[[Antibodies]] pass [[placenta]] cause [[hypothyroidism]]
**Antithyroid medications usage that can cross the placenta   
**[[Antithyroid agents|Antithyroid medications]] usage that can cross the [[placenta]]  
**Iodine deficiency   
**[[Iodine deficiency]]  
**Inability to uptake iodide   
**Inability to uptake [[iodide]]  


=== Secondary (central) hypothyroidism ===
=== Secondary (central) hypothyroidism ===
Central hypothyroidism is caused by:<ref name="pmid14671180">{{cite journal| author=Kempers MJ, van Tijn DA, van Trotsenburg AS, de Vijlder JJ, Wiedijk BM, Vulsma T| title=Central congenital hypothyroidism due to gestational hyperthyroidism: detection where prevention failed. | journal=J Clin Endocrinol Metab | year= 2003 | volume= 88 | issue= 12 | pages= 5851-7 | pmid=14671180 | doi=10.1210/jc.2003-030665 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14671180  }}</ref>
Central hypothyroidism is caused by:<ref name="pmid14671180">{{cite journal| author=Kempers MJ, van Tijn DA, van Trotsenburg AS, de Vijlder JJ, Wiedijk BM, Vulsma T| title=Central congenital hypothyroidism due to gestational hyperthyroidism: detection where prevention failed. | journal=J Clin Endocrinol Metab | year= 2003 | volume= 88 | issue= 12 | pages= 5851-7 | pmid=14671180 | doi=10.1210/jc.2003-030665 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14671180  }}</ref>
* Inflammation or infection of pituitary gland and hypothalamus  
* [[Inflammation]] or [[infection]] of [[pituitary gland]] and [[hypothalamus]]
* Trauma  
* [[Trauma]]
* Structural changes  
* Structural changes  
* Untreated maternal hyperthyroidism during pregnancy  
* Untreated maternal [[hypothyroidism]] during [[Cardiac disease in pregnancy epidemiology and demographics|pregnancy]]


===Genetic Causes===
===Genetic Causes===
*Cretinism is caused by a mutation in the TTF-2 gene.
*Cretinism is caused by a [[mutation]] in the TTF-2 gene.
*Cretinism is caused by a mutation in the genes responsible for the thyroid hormone secretion. These genes include the following:<ref name="pmid21900383">{{cite journal| author=Narumi S, Muroya K, Asakura Y, Aachi M, Hasegawa T| title=Molecular basis of thyroid dyshormonogenesis: genetic screening in population-based Japanese patients. | journal=J Clin Endocrinol Metab | year= 2011 | volume= 96 | issue= 11 | pages= E1838-42 | pmid=21900383 | doi=10.1210/jc.2011-1573 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21900383  }}</ref><ref name="pmid18426362">{{cite journal| author=Ohye H, Fukata S, Hishinuma A, Kudo T, Nishihara E, Ito M et al.| title=A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter. | journal=Thyroid | year= 2008 | volume= 18 | issue= 5 | pages= 561-6 | pmid=18426362 | doi=10.1089/thy.2007.0258 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18426362  }}</ref>
*Cretinism is caused by a mutation in the genes responsible for the [[thyroid hormone]] secretion. These genes include the following:<ref name="pmid21900383">{{cite journal| author=Narumi S, Muroya K, Asakura Y, Aachi M, Hasegawa T| title=Molecular basis of thyroid dyshormonogenesis: genetic screening in population-based Japanese patients. | journal=J Clin Endocrinol Metab | year= 2011 | volume= 96 | issue= 11 | pages= E1838-42 | pmid=21900383 | doi=10.1210/jc.2011-1573 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21900383  }}</ref><ref name="pmid18426362">{{cite journal| author=Ohye H, Fukata S, Hishinuma A, Kudo T, Nishihara E, Ito M et al.| title=A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter. | journal=Thyroid | year= 2008 | volume= 18 | issue= 5 | pages= 561-6 | pmid=18426362 | doi=10.1089/thy.2007.0258 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18426362  }}</ref>
**Dual oxidase 2 gene (DUOX 2)
**[[DUOX2|Dual oxidase 2 gene (DUOX 2)]]
**Thyroglobulin gene (TG)  
**[[Thyroglobulin|Thyroglobulin gene (TG)]]
**Thyroid peroxidase (gene (TPO)  
**[[Thyroid peroxidase|Thyroid peroxidase gene (TPO)]]
**Thyroid stimulating hormone receptor gene (TSHR) 
**[[Thyroid-stimulating hormone|Thyroid stimulating hormone receptor gene (TSHR)]] 


===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
List the causes of the disease in alphabetical order.
List the causes of the disease in alphabetical order.
{{columns-list|3|
{{columns-list|
*Antibodies  
*[[Antibodies]]
*Antithyroid medications
*[[Antithyroid agents|Antithyroid medications]]
*Autoimmune diseases
*[[Autoimmune diseases]]
*Ectopic thyroid  
*[[Ectopic]] [[thyroid gland]]
*Iodine deficiency
*[[Iodine deficiency]]
*Infection  
*[[Infection]]
*Inflammation  
*[[Inflammation]]
*Maternal [[hypothyroidism]]
*Structural changes
*Structural changes
*Maternal hyperthyroidism
*[[Thyroid dysgenesis]]
*Thyroid dysgenesis
*Thyroid dyshormonogenesis
*Thyroid dyshormonogenesis
*Trauma
*[[Trauma]]
}}
}}


Line 59: Line 60:
{{WH}}
{{WH}}
{{WS}}
{{WS}}
​​[[Category:Medicine]]
[[Category:Endocrinology]]
[[Category:Up-To-Date]]​
[[Category:Pediatrics]]

Latest revision as of 20:40, 10 January 2020

Cretinism Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Cretinism from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Cretinism causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Cretinism causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Cretinism causes

CDC on Cretinism causes

Cretinism causes in the news

Blogs on Cretinism causes

Directions to Hospitals Treating Cretinism

Risk calculators and risk factors for Cretinism causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Cretinism may be caused by congenital causes like thyroid dysgenesis and ectopic thyroid gland. Cretinism may be caused by other causes like antithyroid medications and iodine deficiency.

Causes

Primary cretinism

Common Causes

Primary Cretinism may be caused by:[1][2]

Secondary (central) hypothyroidism

Central hypothyroidism is caused by:[3]

Genetic Causes

Causes in Alphabetical Order

List the causes of the disease in alphabetical order.

References

  1. ↑ Persani L, Calebiro D, Cordella D, Weber G, Gelmini G, Libri D; et al. (2010). "Genetics and phenomics of hypothyroidism due to TSH resistance". Mol Cell Endocrinol. 322 (1–2): 72–82. doi:10.1016/j.mce.2010.01.008. PMID 20083154.
  2. ↑ Wassner AJ (2017). "Pediatric Hypothyroidism: Diagnosis and Treatment". Paediatr Drugs. 19 (4): 291–301. doi:10.1007/s40272-017-0238-0. PMID 28534114.
  3. ↑ Kempers MJ, van Tijn DA, van Trotsenburg AS, de Vijlder JJ, Wiedijk BM, Vulsma T (2003). "Central congenital hypothyroidism due to gestational hyperthyroidism: detection where prevention failed". J Clin Endocrinol Metab. 88 (12): 5851–7. doi:10.1210/jc.2003-030665. PMID 14671180.
  4. ↑ Narumi S, Muroya K, Asakura Y, Aachi M, Hasegawa T (2011). "Molecular basis of thyroid dyshormonogenesis: genetic screening in population-based Japanese patients". J Clin Endocrinol Metab. 96 (11): E1838–42. doi:10.1210/jc.2011-1573. PMID 21900383.
  5. ↑ Ohye H, Fukata S, Hishinuma A, Kudo T, Nishihara E, Ito M; et al. (2008). "A novel homozygous missense mutation of the dual oxidase 2 (DUOX2) gene in an adult patient with large goiter". Thyroid. 18 (5): 561–6. doi:10.1089/thy.2007.0258. PMID 18426362.

Template:WH Template:WS ​​​

Retrieved from "https://www.wikidoc.org/index.php?title=Cretinism_causes&oldid=1594743"