Osteoarthritis causes: Difference between revisions

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Latest revision as of 22:14, 10 January 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammadmain Rezazadehsaatlou [2] Robert G. Badgett, M.D. [2] Luke Rusowicz-Orazem, B.S.; , Irfan Dotani [4]

Overview

Osteoarthritis (OA) is a result of a variety of disorders that lead to structural and functional failure in involved joints. Osteoarthritis, traditionally, has been considered as a disease specifically related to articular cartilage. Presently, it's been proven that OA influencing the whole joint system consisted of capsule, and synovium, subchondral bone, cartilage, menisci, ligaments, and periarticular muscle^[1]^[2].

Causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	No underlying causes
Dental	No underlying causes
Dermatologic	Paget disease
Drug Side Effect	No underlying causes
Ear Nose Throat	No underlying causes
Endocrine	Acromegaly, Hemochromatosis, hyperparathyroidism, Pituitary cancer, Pituitary tumors, Reduced sex hormones
Environmental	No underlying causes
Gastroenterologic	Hemochromatosis, Wilson disease
Genetic	Adam12, Alkaptonuria , Asymmetric leg length, Bmp, Clip, Col11a2, Ehlers-danlos syndrome, Erg, Familial chondrocalcinosis, Frzb, Gdf5, Il10, Larsen syndrome , Mcf2l, Mmp3, Multiple epiphyseal dysplasia , Nail-patella syndrome , Osteochondritis dissecans , Spondyloepiphyseal dysplasia tarda , Tgfb1, Thalassemia, Wilson disease
Hematologic	Diabetes, Hemochromatosis, Thalassemia
Iatrogenic	Meniscectomy, Surgery
Infectious Disease	Syringomyelia, Tabes dorsalis, Viral hepatitis
Musculoskeletal/Orthopedic	Aseptic necrosis of bone, Asymmetric leg length, Avascular necrosis, Chondrocalcinosis 1 , Chondrocalcinosis 2, Developmental dysplasia of the hip, Ehlers-danlos syndrome, Familial chondrocalcinosis, Fracture of bone, Joint injury, Meniscectomy, Multiple epiphyseal dysplasia , Muscle dysfunction, Osteochondritis dissecans , Syringomyelia, Tabes dorsalis
Neurologic	No underlying causes
Nutritional/Metabolic	Diabetes, Obesity
Obstetric/Gynecologic	No underlying causes
Oncologic	Pituitary cancer, Pituitary tumors
Ophthalmologic	No underlying causes
Overdose/Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	Allergies, Aseptic necrosis of bone, Avascular necrosis, Chondrocalcinosis 1 , Chondrocalcinosis 2, Crystal deposition, Gout, Lupus, Rheumatoid arthritis, Satoyoshi syndrome
Sexual	No underlying causes
Trauma	Developmental dysplasia of the hip, Fracture of bone, Joint injury, Physical trauma, Trauma
Urologic	Alkaptonuria
Miscellaneous	Aging

===Causes in Alphabetical Order=== ^[3]^[4]^[5]

References

↑ Bennet D (March 1993). "Arthritis--its classification, pathogenesis and clinical relevance". Tijdschr Diergeneeskd. 118 Suppl 1: 19S–23S. PMID 8480308.
↑ Man GS, Mologhianu G (March 2014). "Osteoarthritis pathogenesis - a complex process that involves the entire joint". J Med Life. 7 (1): 37–41. PMC 3956093. PMID 24653755.
↑ Renberg WC (September 2005). "Pathophysiology and management of arthritis". Vet. Clin. North Am. Small Anim. Pract. 35 (5): 1073–91, v. doi:10.1016/j.cvsm.2005.05.005. PMID 16129133.
↑ Harari J (July 1997). "Clinical evaluation of the osteoarthritic patient". Vet. Clin. North Am. Small Anim. Pract. 27 (4): 725–34. PMID 9243778.
↑ Rychel JK (February 2010). "Diagnosis and treatment of osteoarthritis". Top Companion Anim Med. 25 (1): 20–5. doi:10.1053/j.tcam.2009.10.005. PMID 20188335.

Template:WH Template:WS

[pmid8480308-1] Bennet D (March 1993). "Arthritis--its classification, pathogenesis and clinical relevance". Tijdschr Diergeneeskd. 118 Suppl 1: 19S–23S. PMID 8480308.

[pmid24653755-2] Man GS, Mologhianu G (March 2014). "Osteoarthritis pathogenesis - a complex process that involves the entire joint". J Med Life. 7 (1): 37–41. PMC 3956093. PMID 24653755.

[pmid16129133-3] Renberg WC (September 2005). "Pathophysiology and management of arthritis". Vet. Clin. North Am. Small Anim. Pract. 35 (5): 1073–91, v. doi:10.1016/j.cvsm.2005.05.005. PMID 16129133.

[pmid9243778-4] Harari J (July 1997). "Clinical evaluation of the osteoarthritic patient". Vet. Clin. North Am. Small Anim. Pract. 27 (4): 725–34. PMID 9243778.

[pmid20188335-5] Rychel JK (February 2010). "Diagnosis and treatment of osteoarthritis". Top Companion Anim Med. 25 (1): 20–5. doi:10.1053/j.tcam.2009.10.005. PMID 20188335.

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
+[[File:Osteoarthritis causes.jpg|thumb|Osteoarthritis causes]]
 __NOTOC__
 {{Osteoarthritis}}
-{{CMG}}
+{{CMG}} {{AE}}[[User:DrMars|Mohammadmain Rezazadehsaatlou]] [2] {{Badgett}} {{LRO}}; , [[User:Irfan Dotani|Irfan Dotani]] [4]
 ==Overview==
-==Causes==
+Osteoarthritis (OA) is a result of a variety of disorders that lead to structural and functional failure in involved joints. Osteoarthritis, traditionally, has been considered as a disease specifically related to articular cartilage. Presently, it's been proven that OA influencing the whole joint system consisted of capsule, and synovium, subchondral bone, cartilage, menisci, ligaments, and periarticular muscle<ref name="pmid8480308">{{cite journal |vauthors=Bennet D |title=Arthritis--its classification, pathogenesis and clinical relevance |journal=Tijdschr Diergeneeskd |volume=118 Suppl 1 |issue= |pages=19S–23S |date=March 1993 |pmid=8480308 |doi= |url=}}</ref><ref name="pmid24653755">{{cite journal |vauthors=Man GS, Mologhianu G |title=Osteoarthritis pathogenesis - a complex process that involves the entire joint |journal=J Med Life |volume=7 |issue=1 |pages=37–41 |date=March 2014 |pmid=24653755 |pmc=3956093 |doi= |url=}}</ref>.
-Osteoarthritis often affects multiple members of the same family, suggesting that there is [[hereditary]] susceptibility to this condition. A number of studies have shown that there is a greater prevalence of the disease between siblings and especially [[Twin#Identical twins|identical twins]], indicating a hereditary basis. Up to 60% of OA cases are thought to result from genetic factors. Researchers are also investigating the possibility of [[Allergy|allergies]], [[infection]]s, or [[Mycosis|fungi]] as a cause. There is some evidence that allergies, whether fungal, infectious or systemically induced, may be a significant contributing factor to the appearance of osteoarthritis in a synovial sac. Randomized, controlled studies have shown a 40% reduction in joint degeneration if [[Tetracycline]] derivative antibiotics are taken consistently over time.
+==Causes==
+<div style="-webkit-user-select: none;">
+===Causes by Organ System===
+{| style="width:80%; height:100px" border="1"
+| style="width:25%" bgcolor="LightSteelBlue" ; border="1" |'''Cardiovascular'''
+| style="width:75%" bgcolor="Beige" ; border="1" | No underlying causes
+|-
+| bgcolor="LightSteelBlue" | '''Chemical/Poisoning'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Dental'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Dermatologic'''
+| bgcolor="Beige" | [[Paget disease]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Drug Side Effect'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Ear Nose Throat'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Endocrine'''
+| bgcolor="Beige" | [[Acromegaly]],  [[Hemochromatosis]], [[hyperparathyroidism]], [[Pituitary cancer]],  [[Pituitary tumors]],  [[Reduced sex hormones]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Environmental'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Gastroenterologic'''
+| bgcolor="Beige" | [[Hemochromatosis]],  [[Wilson disease]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Genetic'''
+| bgcolor="Beige" | [[Adam12]],  [[Alkaptonuria ]] ,  [[Asymmetric leg length]],  [[Bmp]],  [[Clip]],  [[Col11a2]],  [[Ehlers-danlos syndrome]],  [[Erg]],  [[Familial chondrocalcinosis]],  [[Frzb]],  [[Gdf5]],  [[Il10]],  [[Larsen syndrome ]] ,  [[Mcf2l]],  [[Mmp3]],  [[Multiple epiphyseal dysplasia ]] ,  [[Nail-patella syndrome ]] ,  [[Osteochondritis dissecans ]] ,  [[Spondyloepiphyseal dysplasia tarda ]] ,  [[Tgfb1]],  [[Thalassemia]],  [[Wilson disease]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Hematologic'''
+| bgcolor="Beige" | [[Diabetes]],  [[Hemochromatosis]],  [[Thalassemia]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Iatrogenic'''
+| bgcolor="Beige" | [[Meniscectomy]],  [[Surgery]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Infectious Disease'''
+| bgcolor="Beige" | [[Syringomyelia]],  [[Tabes dorsalis]],  [[Viral hepatitis]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Musculoskeletal/Orthopedic'''
+| bgcolor="Beige" | [[Aseptic necrosis of bone]],  [[Asymmetric leg length]],  [[Avascular necrosis]],  [[Chondrocalcinosis 1 ]] ,  [[Chondrocalcinosis 2]],  [[Developmental dysplasia of the hip]],  [[Ehlers-danlos syndrome]],  [[Familial chondrocalcinosis]],  [[Fracture of bone]],  [[Joint injury]],  [[Meniscectomy]],  [[Multiple epiphyseal dysplasia ]] ,  [[Muscle dysfunction]],  [[Osteochondritis dissecans ]] ,  [[Syringomyelia]],  [[Tabes dorsalis]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Neurologic'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Nutritional/Metabolic'''
+| bgcolor="Beige" | [[Diabetes]],  [[Obesity]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Obstetric/Gynecologic'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Oncologic'''
+| bgcolor="Beige" | [[Pituitary cancer]],  [[Pituitary tumors]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Ophthalmologic'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Overdose/Toxicity'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Psychiatric'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Pulmonary'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Renal/Electrolyte'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Rheumatology/Immunology/Allergy'''
+| bgcolor="Beige" | [[Allergies]],  [[Aseptic necrosis of bone]],  [[Avascular necrosis]],  [[Chondrocalcinosis 1 ]] ,  [[Chondrocalcinosis 2]],  [[Crystal deposition]],  [[Gout]],  [[Lupus]],  [[Rheumatoid arthritis]],  [[Satoyoshi syndrome]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Sexual'''
+| bgcolor="Beige" | No underlying causes
+|-
+|- bgcolor="LightSteelBlue"
+| '''Trauma'''
+| bgcolor="Beige" | [[Developmental dysplasia of the hip]],  [[Fracture of bone]],  [[Joint injury]],  [[Physical trauma]],  [[Trauma]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Urologic'''
+| bgcolor="Beige" | [[Alkaptonuria ]]
+|-
+|- bgcolor="LightSteelBlue"
+| '''Miscellaneous'''
+| bgcolor="Beige" | [[Aging]]
+|-
+|}
+===Causes in Alphabetical Order=== <ref name="pmid16129133">{{cite journal |vauthors=Renberg WC |title=Pathophysiology and management of arthritis |journal=Vet. Clin. North Am. Small Anim. Pract. |volume=35 |issue=5 |pages=1073–91, v |date=September 2005 |pmid=16129133 |doi=10.1016/j.cvsm.2005.05.005 |url=}}</ref><ref name="pmid9243778">{{cite journal |vauthors=Harari J |title=Clinical evaluation of the osteoarthritic patient |journal=Vet. Clin. North Am. Small Anim. Pract. |volume=27 |issue=4 |pages=725–34 |date=July 1997 |pmid=9243778 |doi= |url=}}</ref><ref name="pmid20188335">{{cite journal |vauthors=Rychel JK |title=Diagnosis and treatment of osteoarthritis |journal=Top Companion Anim Med |volume=25 |issue=1 |pages=20–5 |date=February 2010 |pmid=20188335 |doi=10.1053/j.tcam.2009.10.005 |url=}}</ref>
+{{columns-list|
+*[[Acromegaly]]
+*[[Adam12]]
+*[[Aging]]
+*[[Alkaptonuria ]]
+*[[Allergies]]
+*[[Aseptic necrosis of bone]]
+*[[Asymmetric leg length]]
+*[[Avascular necrosis]]
+*[[Bmp]]
+*[[Chondrocalcinosis 1 ]]
+*[[Chondrocalcinosis 2]]
+*[[Clip]]
+*[[Col11a2]]
+*[[Crystal deposition]]
+*[[Developmental dysplasia of the hip]]
+*[[Diabetes]]
+*[[Ehlers-danlos syndrome]]
+*[[Erg]]
+*[[Familial chondrocalcinosis]]
+*[[Fracture of bone]]
+*[[Frzb]]
+*[[Gdf5]]
+*[[Gout]]
+*[[Hemochromatosis]]
+*[[Hyperparathyroidism]]
+*[[Il10]]
+*[[Joint injury]]
+*[[Larsen syndrome ]]
+*[[Lupus]]
+*[[Mcf2l]]
+*[[Meniscectomy]]
+*[[Mmp3]]
+*[[Multiple epiphyseal dysplasia ]]
+*[[Muscle dysfunction]]
+*[[Nail-patella syndrome ]]
+*[[Obesity]]
+*[[Osteochondritis dissecans ]]
+*[[Paget disease]]
+*[[Physical trauma]]
+*[[Pituitary cancer]]
+*[[Pituitary tumors]]
+*[[Reduced sex hormones]]
+*[[Rheumatoid arthritis]]
+*[[Satoyoshi syndrome]]
+*[[Spondyloepiphyseal dysplasia tarda ]]
+*[[Surgery]]
+*[[Syringomyelia]]
+*[[Tabes dorsalis]]
+*[[Tgfb1]]
+*[[Thalassemia]]
+*[[Trauma]]
+*[[Viral hepatitis]]
+*[[Wilson disease]]
+}}
+</div>
 ==References==
 {{reflist|2}}
 {{WH}}
 {{WS}}
-[[Category:Arthritis]]
-[[Category:General practice]]
 [[Category:Rheumatology]]