Central pontine myelinolysis diagnostic study of choice: Difference between revisions

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Latest revision as of 16:21, 2 April 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Brain MRI is the gold standard test for the diagnosis of central pontine myelinolysis. The following findings on performing Brain MRI are confirmatory for central pontine myelinolysis: T2 hyperintensity in the central pontine region in the axial plane and hyperintense lesion in the midpons in the midsagittal T2-weighted MRI.

Diagnostic Study of Choice

Study of choice

Brain MRI is the gold standard test for the diagnosis of central pontine myelinolysis.^[1]

Diagnostic results

The following findings on performing Brain MRI are confirmatory for central pontine myelinolysis:^[1]^[2]

T2 hyperintensity in the central pontine region in the axial plane
Hyperintense lesion in the midpons in the midsagittal T2-weighted MRI

References

↑ ^1.0 ^1.1 Lambeck J, Hieber M, Dreßing A, Niesen WD (2019). "Central Pontine Myelinosis and Osmotic Demyelination Syndrome". Dtsch Arztebl Int. 116 (35–36): 600–606. doi:10.3238/arztebl.2019.0600. PMC 6804268 Check |pmc= value (help). PMID 31587708.
↑ Thompson PD, Miller D, Gledhill RF, Rossor MN (1989). "Magnetic resonance imaging in central pontine myelinolysis". J Neurol Neurosurg Psychiatry. 52 (5): 675–7. doi:10.1136/jnnp.52.5.675. PMC 1032189. PMID 2732743.

Template:WH Template:WS

[pmid31587708-1] 1.0 ^1.1 Lambeck J, Hieber M, Dreßing A, Niesen WD (2019). "Central Pontine Myelinosis and Osmotic Demyelination Syndrome". Dtsch Arztebl Int. 116 (35–36): 600–606. doi:10.3238/arztebl.2019.0600. PMC 6804268 Check |pmc= value (help). PMID 31587708.

[pmid2732743-2] Thompson PD, Miller D, Gledhill RF, Rossor MN (1989). "Magnetic resonance imaging in central pontine myelinolysis". J Neurol Neurosurg Psychiatry. 52 (5): 675–7. doi:10.1136/jnnp.52.5.675. PMC 1032189. PMID 2732743.

[1]

[2]

@@ Line 3: / Line 3: @@
 {{CMG}}; {{AE}}{{MMJ}}
 == Overview ==
+Brain MRI is the gold standard test for the diagnosis of central pontine myelinolysis. The following findings on performing Brain MRI are confirmatory for central pontine myelinolysis: T2 hyperintensity in the central [[pontine]] region in the axial plane and hyperintense lesion in the midpons in the midsagittal T2-weighted [[MRI]].
 == Diagnostic Study of Choice ==
 === Study of choice ===
-[Name of the investigation] is the gold standard test for the diagnosis of [disease name].
+Brain MRI is the gold standard test for the diagnosis of central pontine myelinolysis.<ref name="pmid31587708">{{cite journal| author=Lambeck J, Hieber M, Dreßing A, Niesen WD| title=Central Pontine Myelinosis and Osmotic Demyelination Syndrome. | journal=Dtsch Arztebl Int | year= 2019 | volume= 116 | issue= 35-36 | pages= 600-606 | pmid=31587708 | doi=10.3238/arztebl.2019.0600 | pmc=6804268 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31587708  }} </ref>
-OR
-The following result of [gold standard test] is confirmatory of [disease name]:
-* [Result 1]
-* [Result 2]
-OR
-[Name of the investigation] must be performed when:
-* The patient presents with [symptom/sign 1], [symptom/sign 2], and [symptom/sign 3].
-* A [name of test] is positive for [sign 1], [sign 2], and [sign 3] in the patient.
-OR
-[Name of the investigation] is the gold standard test for the diagnosis of [disease name].
-OR
-The diagnostic study of choice for [disease name] is [name of the investigation].
-OR
-There is no single diagnostic study of choice for the diagnosis of [disease name].
-OR
-There is no single diagnostic study of choice for the diagnosis of [disease name], but [disease name] can be diagnosed based on [name of the investigation 1] and [name of the investigation 2].
-OR
-[Disease name] is primarily diagnosed based on the clinical presentation.
-OR
-Investigations:
-* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most specific test for the diagnosis.
-* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most sensitive test for diagnosis.
-* Among the patients who present with clinical signs of [disease name], the [investigation name] is the most efficient test for diagnosis.
-==== The comparison of various diagnostic studies for [disease name] ====
-{|
-|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" | Test
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Sensitivity
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Specificity
-|-
-! style="background: #696969; color: #FFFFFF; text-align: center;" |Test 1
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
-|-
-! style="background: #696969; color: #FFFFFF; text-align: center;" |Test 2
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |...%
-|}
-<small> [Name of test with higher sensitivity and specificity] is the preferred investigation based on the sensitivity and specificity</small>
 ===== Diagnostic results =====
-The following finding(s) on performing [investigation name] is(are) confirmatory for [disease name]:
+The following findings on performing Brain MRI are confirmatory for central pontine myelinolysis:<ref name="pmid31587708">{{cite journal| author=Lambeck J, Hieber M, Dreßing A, Niesen WD| title=Central Pontine Myelinosis and Osmotic Demyelination Syndrome. | journal=Dtsch Arztebl Int | year= 2019 | volume= 116 | issue= 35-36 | pages= 600-606 | pmid=31587708 | doi=10.3238/arztebl.2019.0600 | pmc=6804268 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31587708  }} </ref><ref name="pmid2732743">{{cite journal| author=Thompson PD, Miller D, Gledhill RF, Rossor MN| title=Magnetic resonance imaging in central pontine myelinolysis. | journal=J Neurol Neurosurg Psychiatry | year= 1989 | volume= 52 | issue= 5 | pages= 675-7 | pmid=2732743 | doi=10.1136/jnnp.52.5.675 | pmc=1032189 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2732743  }} </ref>
-* [Finding 1]
+* T2 hyperintensity in the central [[pontine]] region in the axial plane
-* [Finding 2]
+* Hyperintense lesion in the midpons in the midsagittal T2-weighted [[MRI]]
-===== Sequence of Diagnostic Studies =====
-The [name of investigation] must be performed when:
-* The patient presented with symptoms/signs 1, 2, and 3 as the first step of diagnosis.
-* A positive [test] is detected in the patient, to confirm the diagnosis.
-OR
-The various investigations must be performed in the following order:
-* [Initial investigation]
-* [2nd investigation]
-=== Name of Diagnostic Criteria ===
-'''It is recommended that you include the criteria in a table. Make sure you always cite the source of the content and whether the table has been adapted from another source.'''
-[Disease name] is primarily diagnosed based on clinical presentation. There are no established criteria for the diagnosis of [disease name].
-OR
-There is no single diagnostic study of choice for [disease name], though [disease name] may be diagnosed based on [name of criteria] established by [...].
-OR
-The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
-OR
-The diagnosis of [disease name] is based on the [criteria name] criteria, which includes [criterion 1], [criterion 2], and [criterion 3].
-OR
-[Disease name] may be diagnosed at any time if one or more of the following criteria are met:
-* Criteria 1
-* Criteria 2
-* Criteria 3
-OR
-'''IF there are clear, established diagnostic criteria'''
-The diagnosis of [disease name] is made when at least [number] of the following [number] diagnostic criteria are met: [criterion 1], [criterion 2], [criterion 3], and [criterion 4].
-OR
-The diagnosis of [disease name] is based on the [criteria name] criteria, which include [criterion 1], [criterion 2], and [criterion 3].
-OR
-The diagnosis of [disease name] is based on the [definition name] definition, which includes [criterion 1], [criterion 2], and [criterion 3].
-OR
-'''IF there are no established diagnostic criteria'''
-There are no established criteria for the diagnosis of [disease name].
 ==References==