HIV associated nephropathy laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{HIV associated nephropathy}} | {{HIV associated nephropathy}} | ||
{{CMG}}{{APM}};{{AE}}{{KW}} | {{CMG}}{{APM}};{{AE}}{{KW}} {{SHA}} | ||
==Overview== | ==Overview== | ||
Laboratory findings in HIV-associated nephropathy include: [[proteinuria]], elevated serum [[creatinine]] levels, decreased [[Glomerular filtration rate|GFR]], dyslipidemia, and [[CD4]] counts below 200 cells/mm<sup>3</sup> .<ref name="pmid22248510" /><ref name="pmid21745806" /> | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
HIV-associated nephropathy (HIVAN) can not be diagnosed clinically or with [[Non-invasive (medical)|noninvasive]] measures such as laboratory findings or ultrasound.<ref name="pmid18588500">{{cite journal| author=Atta MG, Lucas GM, Fine DM| title=HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and management. | journal=Expert Rev Anti Infect Ther | year= 2008 | volume= 6 | issue= 3 | pages= 365-71 | pmid=18588500 | doi=10.1586/14787210.6.3.365 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18588500 }} </ref><ref name="pmid16271919">{{cite journal| author=Atta MG, Choi MJ, Longenecker JC, Haymart M, Wu J, Nagajothi N | display-authors=etal| title=Nephrotic range proteinuria and CD4 count as noninvasive indicators of HIV-associated nephropathy. | journal=Am J Med | year= 2005 | volume= 118 | issue= 11 | pages= 1288 | pmid=16271919 | doi=10.1016/j.amjmed.2005.05.027 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16271919 }} </ref><ref name="pmid15154526">{{cite journal| author=Atta MG, Longenecker JC, Fine DM, Nagajothi N, Grover DS, Wu J | display-authors=etal| title=Sonography as a predictor of human immunodeficiency virus-associated nephropathy. | journal=J Ultrasound Med | year= 2004 | volume= 23 | issue= 5 | pages= 603-10; quiz 612-3 | pmid=15154526 | doi=10.7863/jum.2004.23.5.603 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15154526 }} </ref> | |||
[[Laboratory]] findings in HIV-associated nephropathy include:<ref name="pmid22248510">{{cite journal| author=Lescure FX, Flateau C, Pacanowski J, Brocheriou I, Rondeau E, Girard PM | display-authors=etal| title=HIV-associated kidney glomerular diseases: changes with time and HAART. | journal=Nephrol Dial Transplant | year= 2012 | volume= 27 | issue= 6 | pages= 2349-55 | pmid=22248510 | doi=10.1093/ndt/gfr676 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22248510 }} </ref><ref name="pmid21745806">{{cite journal| author=Bigé N, Lanternier F, Viard JP, Kamgang P, Daugas E, Elie C | display-authors=etal| title=Presentation of HIV-associated nephropathy and outcome in HAART-treated patients. | journal=Nephrol Dial Transplant | year= 2012 | volume= 27 | issue= 3 | pages= 1114-21 | pmid=21745806 | doi=10.1093/ndt/gfr376 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21745806 }} </ref> | |||
* Proteinuria | |||
* Elevated serum [[creatinine]] levels | |||
*Decreased [[Glomerular filtration rate|GFR]] | |||
* Dyslipidemia | |||
*[[CD4]] counts below 200 cells/mm<sup>3</sup> | |||
Routine [[laboratory]] tests that may be ordered to help in identify HIV-associated nephropathy (HIVAN) may include: | |||
'''Blood Work-up''' | '''Blood Work-up''' | ||
* Complete blood count (CBC) | * Complete blood count (CBC) | ||
* Serum creatinine | * Serum [[creatinine]] | ||
* Lipid profile | *[[Lipid]] profile | ||
* Albumin | *[[Albumin]] | ||
* ELISA | *[[Enzyme linked immunosorbent assay (ELISA)|ELISA]] | ||
* Dot blot | *[[Dot blot]] | ||
* Latex agglutination test | *[[Latex fixation test|Latex agglutination test]] | ||
*[[Hepatitis B]] | |||
*[[Hepatitis C]] | |||
'''Supplemental Test''' | '''Supplemental Test''' | ||
* Western blot | *[[Western blot]] | ||
* Immunofluorescence | *[[Immunofluorescence]] | ||
'''Urinalysis''' | '''Urinalysis''' | ||
* Proteinuria | *[[Proteinuria]] | ||
* Microhematuria | * Microhematuria | ||
* Leukocytes | *[[White blood cells|Leukocytes]] | ||
* Oval fat bodies | * Oval fat bodies | ||
* Hyaline casts | *[[Hyaline]] casts | ||
==References== | ==References== | ||
| Line 38: | Line 51: | ||
[[Category:HIV/AIDS]] | [[Category:HIV/AIDS]] | ||
[[Category:Immune system disorders]] | [[Category:Immune system disorders]] | ||
[[Category:Viral diseases]] | [[Category:Viral diseases]] | ||
Latest revision as of 19:24, 30 June 2020
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HIV associated nephropathy laboratory findings On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2];Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3] Shakiba Hassanzadeh, MD[4]
Overview
Laboratory findings in HIV-associated nephropathy include: proteinuria, elevated serum creatinine levels, decreased GFR, dyslipidemia, and CD4 counts below 200 cells/mm3 .[1][2]
Laboratory Findings
HIV-associated nephropathy (HIVAN) can not be diagnosed clinically or with noninvasive measures such as laboratory findings or ultrasound.[3][4][5]
Laboratory findings in HIV-associated nephropathy include:[1][2]
- Proteinuria
- Elevated serum creatinine levels
- Decreased GFR
- Dyslipidemia
- CD4 counts below 200 cells/mm3
Routine laboratory tests that may be ordered to help in identify HIV-associated nephropathy (HIVAN) may include:
Blood Work-up
- Complete blood count (CBC)
- Serum creatinine
- Lipid profile
- Albumin
- ELISA
- Dot blot
- Latex agglutination test
- Hepatitis B
- Hepatitis C
Supplemental Test
Urinalysis
- Proteinuria
- Microhematuria
- Leukocytes
- Oval fat bodies
- Hyaline casts
References
- ↑ 1.0 1.1 Lescure FX, Flateau C, Pacanowski J, Brocheriou I, Rondeau E, Girard PM; et al. (2012). "HIV-associated kidney glomerular diseases: changes with time and HAART". Nephrol Dial Transplant. 27 (6): 2349–55. doi:10.1093/ndt/gfr676. PMID 22248510.
- ↑ 2.0 2.1 Bigé N, Lanternier F, Viard JP, Kamgang P, Daugas E, Elie C; et al. (2012). "Presentation of HIV-associated nephropathy and outcome in HAART-treated patients". Nephrol Dial Transplant. 27 (3): 1114–21. doi:10.1093/ndt/gfr376. PMID 21745806.
- ↑ Atta MG, Lucas GM, Fine DM (2008). "HIV-associated nephropathy: epidemiology, pathogenesis, diagnosis and management". Expert Rev Anti Infect Ther. 6 (3): 365–71. doi:10.1586/14787210.6.3.365. PMID 18588500.
- ↑ Atta MG, Choi MJ, Longenecker JC, Haymart M, Wu J, Nagajothi N; et al. (2005). "Nephrotic range proteinuria and CD4 count as noninvasive indicators of HIV-associated nephropathy". Am J Med. 118 (11): 1288. doi:10.1016/j.amjmed.2005.05.027. PMID 16271919.
- ↑ Atta MG, Longenecker JC, Fine DM, Nagajothi N, Grover DS, Wu J; et al. (2004). "Sonography as a predictor of human immunodeficiency virus-associated nephropathy". J Ultrasound Med. 23 (5): 603–10, quiz 612-3. doi:10.7863/jum.2004.23.5.603. PMID 15154526.