Cervical cancer causes: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Cervical cancer}} | {{Cervical cancer}} | ||
{{CMG}}; {{AE}} {{Nnasiri}}, {{MD}} | |||
==Overview== | |||
Cervical cancer is caused by an [[infection]] with [[Human papillomavirus]], which is transmitted by skin to skin contact and sexually. Only high risk strains of HPV are causing cervical cancer, having multiple sexual partner is a risk factor for infecting with [[HPV]]. | |||
==Causes== | |||
* [[Human papillomavirus]] is main cause of cervical cancer, only high-risk [[HPV]] types can affect squamous [[epithelium]] of [[cervix]] and cause cancer. | |||
* [[HPV]] is a small, nonenveloped [[DNA]] virus, 55 nm in diameter, and transmits primarily by skin to skin contact. <ref name="pmid12525422">{{cite journal |vauthors=Burd EM |title=Human papillomavirus and cervical cancer |journal=Clin. Microbiol. Rev. |volume=16 |issue=1 |pages=1–17 |date=January 2003 |pmid=12525422 |doi= |url=}}</ref> | |||
* High risk strains include types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70. | |||
* [[HPV]] [[oncogenes]] interfere with [[cell cycle]] control and causes abnormal growth of [[Squamous epithelium|squamous cells in epithelium]] of [[cervix]].<ref name="pmid12525422" /> | |||
* The assosiciation between [[HPV]] infection and [[glandular]] type of cervical [[neoplasia]] is not as strong as that of squamous carcinoma of [[cervix]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WH}} | |||
{{WS}} | |||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Gynecology]] | [[Category:Gynecology]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | [[Category:Oncology]] | ||
[[Category:Medicine]] | |||
Latest revision as of 20:51, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2], Monalisa Dmello, M.B,B.S., M.D. [3]
Overview
Cervical cancer is caused by an infection with Human papillomavirus, which is transmitted by skin to skin contact and sexually. Only high risk strains of HPV are causing cervical cancer, having multiple sexual partner is a risk factor for infecting with HPV.
Causes
- Human papillomavirus is main cause of cervical cancer, only high-risk HPV types can affect squamous epithelium of cervix and cause cancer.
- HPV is a small, nonenveloped DNA virus, 55 nm in diameter, and transmits primarily by skin to skin contact. [1]
- High risk strains include types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70.
- HPV oncogenes interfere with cell cycle control and causes abnormal growth of squamous cells in epithelium of cervix.[1]
- The assosiciation between HPV infection and glandular type of cervical neoplasia is not as strong as that of squamous carcinoma of cervix.