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{{Congenital rubella syndrome}}
{{Congenital rubella syndrome}}
==Overview==
Originally, [[rubella]] was referred to as the ''third disease'', because it was thought to branch from [[measles]] or [[Scarlet fever]]. However, in 1814, it was recognized as a separate entity of disease and became known as ''[[German measles]]''.<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref> In 1941, congenital rubella syndrome was recognized as a complication of [[rubella]] [[infection]] among [[pregnant]] women who became infected with the [[virus]] early in their [[pregnancy]].<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref> An Australian ophthalmologist made the connection and reported 78 cases of congenital [[cataract]] among [[infants]] born to mothers who had a [[Rubella|rubella infection]] early in their [[pregnancy]].<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>
==Historical Perspective==
==Historical Perspective==
The link between congenital [[cataract]]s and maternal rubella infection was first made in 1941 by Australian [[ophthalmologist]], Norman Gregg, who had noticed an unusual number of infants with cataracts following a rubella epidemic in 1940. In the absence of [[vaccination]], rubella is an endemic disease with epidemics every 6 to 9 years. If rubella infections occurred among nonimmune pregnant women, CRS cases can occur. During the 1962–1965 global rubella pandemic, an estimated 12.5 million rubella cases occurred in the United States, resulting in 2,000 cases of encephalitis, 11,250 therapeutic or spontaneous abortions, 2,100 neonatal deaths, and 20,000 infants born with CRS.
*Originally, [[rubella]] was referred to as the ''third disease'', because it was thought to branch from [[measles]] or [[Scarlet fever]]. However, in 1814, it was recognized as a separate entity of disease and became known as ''[[German measles]]''.<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>
*It was not until 1941 that congenital rubella syndrome became recognized as a complication of [[rubella]] [[infection]] among [[pregnant]] women who became infected with the [[virus]] early in their [[pregnancy]].<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>
*This connection was made by the Australian ophthalmologist, ''Norman Gregg'', who reported 78 cases of congenital [[cataract]] among [[pregnant]] women who were infected with [[rubella]] [[virus]] during the early phases of their [[pregnancy]].<ref name="pmid16580940">{{cite journal |vauthors=De Santis M, Cavaliere AF, Straface G, Caruso A |title=Rubella infection in pregnancy |journal=Reprod. Toxicol. |volume=21 |issue=4 |pages=390–8 |year=2006 |pmid=16580940 |doi=10.1016/j.reprotox.2005.01.014 |url=}}</ref><ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>
*[[Rubella]] [[virus]] was first isolated from tissue in 1962.<ref name="pmid4164540">{{cite journal |vauthors=Cooper LZ, Krugman S |title=Clinical manifestations of postnatal and congenital rubella |journal=Arch. Ophthalmol. |volume=77 |issue=4 |pages=434–9 |year=1967 |pmid=4164540 |doi= |url=}}</ref>


In 1969, live attenuated rubella vaccines were licensed in the United States. The goal of the rubella vaccination program was and continues to be to prevent congenital rubella infections, including CRS. Following vaccine licensure, the number of reported cases of CRS in the United States declined dramatically to <1 case per year or 4 cases total during 2005–2011 (CDC, unpublished data). In 28 (85%) of the 33 cases occurring during 1998–2011, the mother was born outside the United States. Of the 33 CRS cases occurring during this time, 16 (48%) were known importations (CDC, unpublished data). In 2004, an independent panel of internationally recognized experts in public health, infectious diseases, and immunizations reviewed the available data on rubella epidemiology and unanimously agreed that rubella elimination (i.e., the absence of year round endemic transmission) was achieved in the United States.
==External link==
http://www.cdc.gov/vaccines/pubs/surv-manual/chpt15-crs.html
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
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Latest revision as of 21:03, 29 July 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

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Overview

Originally, rubella was referred to as the third disease, because it was thought to branch from measles or Scarlet fever. However, in 1814, it was recognized as a separate entity of disease and became known as German measles.[1][2] In 1941, congenital rubella syndrome was recognized as a complication of rubella infection among pregnant women who became infected with the virus early in their pregnancy.[1][2] An Australian ophthalmologist made the connection and reported 78 cases of congenital cataract among infants born to mothers who had a rubella infection early in their pregnancy.[1][2]

Historical Perspective

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 De Santis M, Cavaliere AF, Straface G, Caruso A (2006). "Rubella infection in pregnancy". Reprod. Toxicol. 21 (4): 390–8. doi:10.1016/j.reprotox.2005.01.014. PMID 16580940.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Cooper LZ, Krugman S (1967). "Clinical manifestations of postnatal and congenital rubella". Arch. Ophthalmol. 77 (4): 434–9. PMID 4164540.


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