Congenital syphilis natural history: Difference between revisions
Jump to navigation
Jump to search
m Bot: Removing from Primary care |
|||
| (14 intermediate revisions by 5 users not shown) | |||
| Line 1: | Line 1: | ||
{{CMG}} | __NOTOC__ | ||
{{CMG}} {{AE}} {{KD}} {{AKI}} | |||
{{Congenital syphilis}} | {{Congenital syphilis}} | ||
==Overview== | ==Overview== | ||
Congenital syphilis is a result of [[transplacental transmission]] of the infection and severity of manifestations depend on the duration of maternal infection and duration of exposure to the fetus in utero. | |||
==Natural | ==Natural History, Complications and Prognosis== | ||
== | ===Natural History=== | ||
[[Syphilis]] is a [[sexually transmitted disease]] and is more [[prevalent]] in [[high risk]] population. Women with [[syphilis]] infection can transmit the [[infection]] to the [[fetus]] in utero resulting in a wide spectrum of outcomes. The risk of transmission is higher in [[pregnant]] women who do not undergo regular [[antenatal screening]] or in women who are untreated or adequately treated during the period of [[gestation]]. The risk of transmission to the fetus is dependent on the stage of [[syphilis]] infection in the mother (primary, secondary, tertiary or latent), duration of maternal infection and the exposure to [[fetus]] in utero. The transmission of infection typically occurs during the [[second trimester]] but early [[transmission]] also occurs. [[Syphilis]] can complicate the outcome of [[pregnancy]] and is dependent on the severity of infection in the [[fetus]], severe infection has adverse outcomes in the [[new born]].<ref name="pmid6340889">{{cite journal| author=Charles D| title=Syphilis. | journal=Clin Obstet Gynecol | year= 1983 | volume= 26 | issue= 1 | pages= 125-37 | pmid=6340889 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6340889 }} </ref><ref name="QinFeng2014">{{cite journal|last1=Qin|first1=Jia-Bi|last2=Feng|first2=Tie-Jian|last3=Yang|first3=Tu-Bao|last4=Hong|first4=Fu-Chang|last5=Lan|first5=Li-Na|last6=Zhang|first6=Chun-Lai|last7=Yang|first7=Fan|last8=Mamady|first8=Keita|last9=Dong|first9=Willa|title=Risk Factors for Congenital Syphilis and Adverse Pregnancy Outcomes in Offspring of Women With Syphilis in Shenzhen, China|journal=Sexually Transmitted Diseases|volume=41|issue=1|year=2014|pages=13–23|issn=0148-5717|doi=10.1097/OLQ.0000000000000062}}</ref> | |||
== | ===Complications=== | ||
* | *Severe infection in the [[fetus]] can result in [[spontaneous abortion]], [[stillbirth]], non-immune [[hydrops]], [[intrauterine growth restriction]], and [[perinatal]] death, and other serious sequelae in liveborn.<ref name="pmid24275265">{{cite journal| author=Cohen SE, Klausner JD, Engelman J, Philip S| title=Syphilis in the modern era: an update for physicians. | journal=Infect Dis Clin North Am | year= 2013 | volume= 27 | issue= 4 | pages= 705-22 | pmid=24275265 | doi=10.1016/j.idc.2013.08.005 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24275265 }} </ref> | ||
* | ===Prognosis=== | ||
*Adequate treatment of infected mother during the period of [[gestation]] can prevent the [[transmission]] of disease significantly and treatment of the mother with one dose of [[penicillin]] is proven to improve outcomes in the [[fetus]].<ref name="pmid12232835">{{cite journal |vauthors=Watson-Jones D, Gumodoka B, Weiss H, Changalucha J, Todd J, Mugeye K, Buvé A, Kanga Z, Ndeki L, Rusizoka M, Ross D, Marealle J, Balira R, Mabey D, Hayes R |title=Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomes |journal=J. Infect. Dis. |volume=186 |issue=7 |pages=948–57 |year=2002 |pmid=12232835 |doi=10.1086/342951 |url=}}</ref> | |||
* | *In [[newborns]] and [[infants]] with [[congenital syphilis]] treatment with [[penicillin]] has good [[prognosis]] with normal development.<ref name="pmid21639965">{{cite journal| author=Caddy SC, Lee BE, Sutherland K, Robinson JL, Plitt SS, Read R et al.| title=Pregnancy and neonatal outcomes of women with reactive syphilis serology in Alberta, 2002 to 2006. | journal=J Obstet Gynaecol Can | year= 2011 | volume= 33 | issue= 5 | pages= 453-9 | pmid=21639965 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21639965 }} </ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
{{WikiDoc Help Menu}} | |||
{{WikiDoc Sources}} | |||
[[Category:Disease]] | |||
[[Category:Pediatrics]] | |||
[[Category:Needs content]] | |||
[[Category:Neonatology]] | |||
[[Category:Needs overview]] | |||
[[Category:Emergency medicine]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | |||
[[Category:Obstetrics]] | |||
Latest revision as of 21:04, 29 July 2020
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Aravind Kuchkuntla, M.B.B.S[3]
|
Congenital syphilis Microchapters |
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Congenital syphilis natural history On the Web |
|
American Roentgen Ray Society Images of Congenital syphilis natural history |
|
Risk calculators and risk factors for Congenital syphilis natural history |
Overview
Congenital syphilis is a result of transplacental transmission of the infection and severity of manifestations depend on the duration of maternal infection and duration of exposure to the fetus in utero.
Natural History, Complications and Prognosis
Natural History
Syphilis is a sexually transmitted disease and is more prevalent in high risk population. Women with syphilis infection can transmit the infection to the fetus in utero resulting in a wide spectrum of outcomes. The risk of transmission is higher in pregnant women who do not undergo regular antenatal screening or in women who are untreated or adequately treated during the period of gestation. The risk of transmission to the fetus is dependent on the stage of syphilis infection in the mother (primary, secondary, tertiary or latent), duration of maternal infection and the exposure to fetus in utero. The transmission of infection typically occurs during the second trimester but early transmission also occurs. Syphilis can complicate the outcome of pregnancy and is dependent on the severity of infection in the fetus, severe infection has adverse outcomes in the new born.[1][2]
Complications
- Severe infection in the fetus can result in spontaneous abortion, stillbirth, non-immune hydrops, intrauterine growth restriction, and perinatal death, and other serious sequelae in liveborn.[3]
Prognosis
- Adequate treatment of infected mother during the period of gestation can prevent the transmission of disease significantly and treatment of the mother with one dose of penicillin is proven to improve outcomes in the fetus.[4]
- In newborns and infants with congenital syphilis treatment with penicillin has good prognosis with normal development.[5]
References
- ↑ Charles D (1983). "Syphilis". Clin Obstet Gynecol. 26 (1): 125–37. PMID 6340889.
- ↑ Qin, Jia-Bi; Feng, Tie-Jian; Yang, Tu-Bao; Hong, Fu-Chang; Lan, Li-Na; Zhang, Chun-Lai; Yang, Fan; Mamady, Keita; Dong, Willa (2014). "Risk Factors for Congenital Syphilis and Adverse Pregnancy Outcomes in Offspring of Women With Syphilis in Shenzhen, China". Sexually Transmitted Diseases. 41 (1): 13–23. doi:10.1097/OLQ.0000000000000062. ISSN 0148-5717.
- ↑ Cohen SE, Klausner JD, Engelman J, Philip S (2013). "Syphilis in the modern era: an update for physicians". Infect Dis Clin North Am. 27 (4): 705–22. doi:10.1016/j.idc.2013.08.005. PMID 24275265.
- ↑ Watson-Jones D, Gumodoka B, Weiss H, Changalucha J, Todd J, Mugeye K, Buvé A, Kanga Z, Ndeki L, Rusizoka M, Ross D, Marealle J, Balira R, Mabey D, Hayes R (2002). "Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomes". J. Infect. Dis. 186 (7): 948–57. doi:10.1086/342951. PMID 12232835.
- ↑ Caddy SC, Lee BE, Sutherland K, Robinson JL, Plitt SS, Read R; et al. (2011). "Pregnancy and neonatal outcomes of women with reactive syphilis serology in Alberta, 2002 to 2006". J Obstet Gynaecol Can. 33 (5): 453–9. PMID 21639965.