Graft-versus-host disease other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Biopsies of the suspected organs can be used to help diagnose GvHD. A tissue diagnosis is not necessary, but helps a clinician make the diagnosis in the correct clinical context. The skin, liver, or GI tract can be readily biopsied. | |||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
The diagnosis of GvHD can be made at the histologic level via tissue biopsy. Biopsies of the suspected organs involved can aid in the diagnosis | The diagnosis of GvHD can be made at the histologic level via tissue biopsy. Biopsies of the suspected organs involved can aid in the diagnosis. The sensitivities of tissue biopsy is somewhat limited though, and nearly 40% of cases can be missed.<ref name="pmid23802653">{{cite journal| author=Qian L, Wu Z, Shen J| title=Advances in the treatment of acute graft-versus-host disease. | journal=J Cell Mol Med | year= 2013 | volume= 17 | issue= 8 | pages= 966-75 | pmid=23802653 | doi=10.1111/jcmm.12093 | pmc=3780546 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23802653 }} </ref> | ||
*'''Skin''': A skin biopsy will show findings such as [[vacuolar interface dermatitis]]. Skin biopsy is typically done via a [[punch biopsy]] at bedside, without the requirement of local or general anesthesia. This is the most readily obtainable biopsy as it is the least invasive. | |||
*'''Liver''': A liver biopsy can be obtained via [[transjugular]] or [[percutananeous]] approaches. This is a relatively invasive procedure that requires anesthesia and carries a risk for bleeding and bowel perforation. | |||
*'''GI tract''': A GI tract biopsy can be done via [[endoscopy]] (for upper GI tract) or [[colonoscopy]] or [[flexible sigmoidoscopy]] (for lower GI tract). These are moderately invasive procedures that requires sedation and carries a moderate risk for bleeding. GI tract biopsies are particular important if there is a clinical concern about CMV enteritis or CMV colitis, as it can be quite challenging to differentiate CMV infection from GI GvHD. | |||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Immunology]] | [[Category:Immunology]] | ||
Latest revision as of 21:56, 29 July 2020
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Graft-versus-host disease |
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Differentiating Graft-versus-host disease from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Graft-versus-host disease other diagnostic studies On the Web |
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American Roentgen Ray Society Images of Graft-versus-host disease other diagnostic studies |
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Graft-versus-host disease other diagnostic studies in the news |
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Risk calculators and risk factors for Graft-versus-host disease other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
Biopsies of the suspected organs can be used to help diagnose GvHD. A tissue diagnosis is not necessary, but helps a clinician make the diagnosis in the correct clinical context. The skin, liver, or GI tract can be readily biopsied.
Other Diagnostic Studies
The diagnosis of GvHD can be made at the histologic level via tissue biopsy. Biopsies of the suspected organs involved can aid in the diagnosis. The sensitivities of tissue biopsy is somewhat limited though, and nearly 40% of cases can be missed.[1]
- Skin: A skin biopsy will show findings such as vacuolar interface dermatitis. Skin biopsy is typically done via a punch biopsy at bedside, without the requirement of local or general anesthesia. This is the most readily obtainable biopsy as it is the least invasive.
- Liver: A liver biopsy can be obtained via transjugular or percutananeous approaches. This is a relatively invasive procedure that requires anesthesia and carries a risk for bleeding and bowel perforation.
- GI tract: A GI tract biopsy can be done via endoscopy (for upper GI tract) or colonoscopy or flexible sigmoidoscopy (for lower GI tract). These are moderately invasive procedures that requires sedation and carries a moderate risk for bleeding. GI tract biopsies are particular important if there is a clinical concern about CMV enteritis or CMV colitis, as it can be quite challenging to differentiate CMV infection from GI GvHD.
References
- ↑ Qian L, Wu Z, Shen J (2013). "Advances in the treatment of acute graft-versus-host disease". J Cell Mol Med. 17 (8): 966–75. doi:10.1111/jcmm.12093. PMC 3780546. PMID 23802653.