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   Image          = Crossed-fused-ectopia-003.jpg|
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   Caption        = Renal scan image demonstrates cross-fused renal ectopia. <br> [http://www.radswiki.net Image courtesy of RadsWiki]|
   DiseasesDB    = |
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   ICD10          = {{ICD10|Q|63|2|q|60}} |
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{{Renal ectopia}}
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{{CMG}}; {{AE}}:  [[User:zorkun|Cafer Zorkun]] M.D., PhD.


'''Contributors:''' [[User:zorkun|Cafer Zorkun]] M.D., PhD.
'''Editor:''' [https://www.wikidoc.org/index.php?title=L.Farrukh&action=edit&redlink=1 L.Farrukh]


{{EH}}
{{SK}} Ectopic kidney


==Overview==
==[[Renal ectopia overview|Overview]]==
Renal ectopia is defined as an atypically placed kidney due to faulty migration from the fetal pelvis during embryologic development. Ectopic kidney may be abdominal, lumbar or pelvic, based on its position in the retroperitoneum. It can be placed either ipsilaterally or contralaterally, when it is called crossed renal ectopia.


'''Renal ectopia''' or ''ectopic kidney'' describes a [[kidney]] that is not located in its usual position. It results from the kidney failing to ascend from its origin in the true pelvis or from a superiorly ascended kidney located in the thorax.
==[[Renal ectopia historical perspective|Historical Perspective]]==


==Crossed-fused renal ectopia==
==[[Renal ectopia classification|Classification]]==


* Crossed ectopy = kidney located on the opposite side of the midline from its ureter.
==[[Renal ectopia pathophysiology|Pathophysiology]]==
* In 90% of crossed ectopy, there is at least partial fusion of the kidneys (the remainder demonstrate two discrete kidneys on the same side, crossed-unfused ectopy)
* Due to improper renal ascent in embryogenesis (4<sup>th</sup>-8<sup>th</sup> week of fetal life - normally, the kidney reaches its appropriate position at L2 level at the end of the 2<sup>nd</sup> month)
* Fusion of the kidneys within the pelvis leads to crossed-fused renal ectopia.
* Abnormally situated umbilical artery prevents normal cephalic migration. Another theory is that the ureteric bud crosses to the opposite side and induces nephron formation in the contralateral metanephric blastema.


===Epidemiology===
==[[Renal ectopia causes|Causes]]==


* Incidence: 1 out of 1,000 births.
==[[Renal ectopia differential diagnosis|Differentiating Renal ectopia from other Diseases]]==
* 2:1 male to female ratio
* A single renal mass with two collecting systems is located on one side of the abdomen.
* Left-to-right ectopy three times more common.


===Pathogenesis===
==[[Renal ectopia epidemiology and demographics|Epidemiology and Demographics]]==


* Normal ascent of the kidneys is required for formation of the extraperitoneal perirenal fascial planes.
==[[Renal ectopia risk factors|Risk Factors]]==
* Ectopia (or renal agenesis) results in failure of development of fascial layers in the flanks on the side not occupied by renal tissue.
* Lack of restraining fascia leads to possible malposition of bowel into the extraperitoneal fat of the empty renal fossa and relaxation of mesenteric supports for bowel loops in this region.


===Diagnostic Findings===
==[[Renal ectopia screening|Screening]]==


* Readily detected on conventional urography.
==[[Renal ectopia natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
* CT and US very useful.
* On US, identified by characteristic anterior or posterior "notch" between the two fused kidneys.
* Anterograde or retrograde ureterogram most often demonstrates normal bladder trigone without ureteral ectopy.
* Blood supply usually anomalous.
* Angiography recommended before surgical intervention.
* Findings on CT or barium contrast studies of the bowel should be interpreted in light of bowel laxity in the region of the empty renal fossa (discussed above). In particular, distinction must be made from internal hernia.


'''Patient #1: CT images demonstrate cross-fused renal ectopia'''
==Diagnosis==
<gallery>
[[Renal ectopia diagnostic study of choice|Diagnostic Study of Choice]] | [[Renal ectopia history and symptoms|History and Symptoms]] | [[Renal ectopia physical examination|Physical Examination]] | [[Renal ectopia laboratory findings|Laboratory Findings]] | [[Renal ectopia electrocardiogram|Electrocardiogram]] | [[Renal ectopia x ray|X Ray]] | [[Renal ectopia CT|CT]] | [[Renal ectopia mri|MRI]] | [[Renal ectopia ultrasound|Ultrasound]] | [[Renal ectopia other imaging findings|Other Imaging Findings]] | [[Renal ectopia other diagnostic studies|Other Diagnostic Studies]]
Image:Crossed-fused-ectopia-101.jpg|Kidney 1
Image:Crossed-fused-ectopia-102.jpg|
Image:Crossed-fused-ectopia-103.jpg|Kidney 2
</gallery>


'''Patient #2: Renal scan images demonstrate cross-fused renal ectopia'''
==Treatment==
<gallery>
[[Renal ectopia medical therapy|Medical Therapy]] | [[Renal ectopia surgery|Surgery]] | [[Renal ectopia primary prevention|Primary Prevention]] | [[Renal ectopia secondary prevention|Secondary Prevention]] | [[Renal ectopia cost-effectiveness of therapy| Cost-Effectiveness of Therapy]] | [[Renal ectopia future or investigational therapies|Future or Investigational Therapies]]
Image:Crossed-fused-ectopia-001.jpg
Image:Crossed-fused-ectopia-002.jpg
Image:Crossed-fused-ectopia-003.jpg
</gallery>


===Complications===
==Case Studies==
[[Renal ectopia case study one|Case #1]]


* In a crossed fused renal ectopic kidney, complications such as [[nephrolithiasis]], infection, and [[hydronephrosis]] approaches 50%.
'''Presentation :'''
 
A 28–year-old male presented with recurrent pain in his lower left abdomen present for one month and an episode of hematuria 3 days earlier, accompanied by an attack of acute pain lasting for 3–4 hours. He gave a history of passing 2 small (about 5 mm each) calculi in his urine after the occurrence of hematuria, following which pain decreased in intensity. No history of fever was present.
 
'''Investigations and Findings :'''
 
*Routine blood tests were normal except for erythrocyte sedimentation rate which was slightly raised (38 mm/hr, Westergren method).
*Urine was sterile and serum creatinine and urea were within normal limits.
*The kidneys/ureter/bladder x-ray was unremarkable.
*An emergency ultrasound scan of the abdomen was reported as non-visualization of the left kidney in the left renal region, or elsewhere in the abdomen.
*During scan of the urinary bladder which was normal in outline a jet of urine was seen emerging from the left uretero-vesical junction which was confirmed on color Doppler examination. These sonographic findings led to the impression of an ectopically located left kidney.
*Subsequently, an IVP (intravenous pyelogram) was requested. It revealed that the left kidney was not located in its normal anatomical position and was instead found at the level of L4, L5 and S1 vertebrae, slightly to the left of the midline
*It was smaller compared to the right kidney, measuring 10 cm vertically, 7 cm transversally, and 3.5 cm in thickness (right kidney measured 14×10×4.5 cm). This ectopic kidney was slightly malrotated with its pelvis oriented anteromedially. The long axis passed inferiomedially. It showed normal excretion on IVP.
*The right kidney was normal in size, site and function. No calculus or hydronephrosis was seen. Both ureters were normal with contrast opacification and were opening into the bladder. The left ureter was, however, shorter in its course. The urinary bladder showed normal contrast opacification and on emptying, no significant residual urine was seen.
 
'''Results :'''
 
As the patient did not present with any other complaint, he was discharged with the advice of follow-up ultrasound scans and to report back in case of similar complaints in future.


{{Congenital malformations of genital organs and urinary system}}
{{Congenital malformations of genital organs and urinary system}}
{{SIB}}


[[Category:Nephrology]]
[[Category:Nephrology]]
 
[[Category:Disease]]
{{WH}}
{{WH}}
{{WS}}
{{WS}}

Latest revision as of 15:15, 6 September 2020

Renal ectopia
Renal scan image demonstrates cross-fused renal ectopia.
Image courtesy of RadsWiki
ICD-10 Q63.2
ICD-9 753.3

Renal ectopia Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Renal ectopia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Ultrasound

Other Imaging Findings

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Surgery

Primary Prevention

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: : Cafer Zorkun M.D., PhD.

Editor: L.Farrukh

Synonyms and keywords: Ectopic kidney

Overview

Renal ectopia is defined as an atypically placed kidney due to faulty migration from the fetal pelvis during embryologic development. Ectopic kidney may be abdominal, lumbar or pelvic, based on its position in the retroperitoneum. It can be placed either ipsilaterally or contralaterally, when it is called crossed renal ectopia.

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Renal ectopia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Ultrasound | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

Presentation :

A 28–year-old male presented with recurrent pain in his lower left abdomen present for one month and an episode of hematuria 3 days earlier, accompanied by an attack of acute pain lasting for 3–4 hours. He gave a history of passing 2 small (about 5 mm each) calculi in his urine after the occurrence of hematuria, following which pain decreased in intensity. No history of fever was present.

Investigations and Findings :

  • Routine blood tests were normal except for erythrocyte sedimentation rate which was slightly raised (38 mm/hr, Westergren method).
  • Urine was sterile and serum creatinine and urea were within normal limits.
  • The kidneys/ureter/bladder x-ray was unremarkable.
  • An emergency ultrasound scan of the abdomen was reported as non-visualization of the left kidney in the left renal region, or elsewhere in the abdomen.
  • During scan of the urinary bladder which was normal in outline a jet of urine was seen emerging from the left uretero-vesical junction which was confirmed on color Doppler examination. These sonographic findings led to the impression of an ectopically located left kidney.
  • Subsequently, an IVP (intravenous pyelogram) was requested. It revealed that the left kidney was not located in its normal anatomical position and was instead found at the level of L4, L5 and S1 vertebrae, slightly to the left of the midline
  • It was smaller compared to the right kidney, measuring 10 cm vertically, 7 cm transversally, and 3.5 cm in thickness (right kidney measured 14×10×4.5 cm). This ectopic kidney was slightly malrotated with its pelvis oriented anteromedially. The long axis passed inferiomedially. It showed normal excretion on IVP.
  • The right kidney was normal in size, site and function. No calculus or hydronephrosis was seen. Both ureters were normal with contrast opacification and were opening into the bladder. The left ureter was, however, shorter in its course. The urinary bladder showed normal contrast opacification and on emptying, no significant residual urine was seen.

Results :

As the patient did not present with any other complaint, he was discharged with the advice of follow-up ultrasound scans and to report back in case of similar complaints in future.

Template:WH Template:WS