Papillorenal syndrome medical therapy: Difference between revisions
No edit summary |
|||
| (20 intermediate revisions by the same user not shown) | |||
| Line 3: | Line 3: | ||
{{CMG}} {{AE}} {{Shivam Singla}} | {{CMG}} {{AE}} {{Shivam Singla}} | ||
==Overview== | ==Overview== | ||
The medical management for the patients suffering from [[Renal-coloboma syndrome]] consists of a combination of [[preventive]] as well as a curative component for the [[complications]] or the [[clinical]] manifestations happening in [[patients]] clinically. The most important component is the clinical evaluation of [[patient]] symptoms and signs. The most common evaluation involves a careful assessment of [[Renal]] and [[optical]] manifestations. The early evaluation and workup should be done in patients to cover up all the possible aspects of [[clinical]] manifestations. The [[prevention]] of [[secondary]] [[complications]] is usually important in patients with [[Renal-coloboma syndrome]]. The ongoing [[treatment]] for [[hypertension]] or any other [[medical]] [[illness]] should be provided to the [[patients]] that will further help in the prevention of the development of [[End-stage renal disease]]. Evaluation of family members is also important and must be done to detect any asymptomatic individual in the family so he can be managed at the earliest possible time and severe complications in those patients can be avoided. | |||
==Medical Management== | ==Medical Management== | ||
The medical management for the patients suffering from Renal-coloboma syndrome | The medical management<ref name="urlPAX2-Related Disorder - GeneReviews® - NCBI Bookshelf">{{cite web |url=https://www.ncbi.nlm.nih.gov/books/NBK1451/ |title=PAX2-Related Disorder - GeneReviews® - NCBI Bookshelf |format= |work= |accessdate=}}</ref> for the patients suffering from [[Renal-coloboma syndrome]] consists of a combination of preventive as well as a curative component for the complications or the clinical manifestations happening in patients clinically. The most important component is the clinical evaluation of patient symptoms and signs. The most common evaluation involves a careful assessment of [[Renal]] and [[optical]] manifestations. The following test and workup should be done in patients if not already done to cover up all the possible aspects of clinical manifestations. | ||
1) Evaluation of Renal structure by renal ultrasound | ===Early Evaluation=== | ||
1) Evaluation of Renal structure by [[renal]] [[ultrasound]] | |||
2) Urinalyses to look for the presence of blood and proteins | 2) [[Urinalyses]] to look for the presence of [[blood]] and [[proteins]] | ||
3) Evaluation | 3) Evaluation of the presence of [[vesicoureteral reflux]]. | ||
4) Measurement of renal function by renal by checking serum electrolyte concentration, creatinine and BUN | 4) Measurement of [[renal]] function by [[renal]] by checking serum electrolyte concentration, [[creatinine]], and [[BUN]] concentration levels. | ||
4) Voiding Cystourethrogram | 4) Voiding Cystourethrogram | ||
5) Eye and ear examination- Audiologic testing to look for the presence of hearing loss | 5) [[Eye]] and [[ear]] examination- [[Audiologic]] testing to look for the presence of [[hearing loss]]. | ||
6) [[Genetic]] counseling | |||
7) Team approach that usually includes [[ophthalmologist]], [[nephrologist]], [[audiologist]] along with clinical [[genetic]] specialist. | |||
The prevention of complications is the most important component involved in | ===Prevention of complications=== | ||
The prevention of complications is the most important component involved in patient care. | |||
Most importantly focuses on the prevention of | Most importantly focuses on the prevention of | ||
| Line 39: | Line 33: | ||
*Vision Loss resulting from the detachment of retinal epithelium. | *Vision Loss resulting from the detachment of retinal epithelium. | ||
===Treatment for ongoing symptoms and complications=== | |||
The treatment approach for patients with Renal-coloboma syndrome mainly involves the team of Nephrologists, Ophthalmologists, Audiologists. The ongoing treatment helps in the better control of symptoms and giving patients a better quality of life. | |||
*Managing the patients for hypertension and the vesicoureteral reflux that might be affecting the long-term renal outcome and the renal function. | |||
*This helps in preventing the development of end-stage renal disease in patients. | |||
*ESRD if develops - dialysis, and/or renal transplantation. | |||
*Vision experts or ophthalmologists are helpful in correcting the vision and help in the occurrence of significant vision loss.<br /> | |||
ESRD if develops | |||
==Prevention== | |||
===Prevention of secondary complications=== | |||
Prevention of secondary complications is usually performed for the patients having some form of congenital abnormalities. | |||
*If patient is having congenital optic disc abnormalities the secondary prevention is done | |||
*close follow-up with the ophthalmologist and protective eyewear. | |||
===Avoid=== | |||
Avoid the use of medications and substances that can negatively impact one's kidney function. | |||
Avoid the | |||
*A nephrologist should always be consulted before starting any medication to avoid any impairment in kidney function. | |||
*Patients are also instructed to avoid contact sports. | |||
===Evaluation of Relatives at Risk=== | |||
It is the most important component in patients with renal coloboma syndrome. | |||
*It is acceptable to evaluate and clarify the genetic status of asymptomatic relatives of patients with Renal-coloboma syndrome. | |||
It is | *It is usually done with the help of genetic testing of the PAX2 pathogenic variant | ||
*To identify asymptomatic family members so a to identify any family member that could be benefited from the therapy. | |||
<br /> | |||
==References== | ==References== | ||
Latest revision as of 16:16, 30 September 2020
|
Papillorenal syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Papillorenal syndrome medical therapy On the Web |
|
American Roentgen Ray Society Images of Papillorenal syndrome medical therapy |
|
Risk calculators and risk factors for Papillorenal syndrome medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shivam Singla, M.D.[2]
Overview
The medical management for the patients suffering from Renal-coloboma syndrome consists of a combination of preventive as well as a curative component for the complications or the clinical manifestations happening in patients clinically. The most important component is the clinical evaluation of patient symptoms and signs. The most common evaluation involves a careful assessment of Renal and optical manifestations. The early evaluation and workup should be done in patients to cover up all the possible aspects of clinical manifestations. The prevention of secondary complications is usually important in patients with Renal-coloboma syndrome. The ongoing treatment for hypertension or any other medical illness should be provided to the patients that will further help in the prevention of the development of End-stage renal disease. Evaluation of family members is also important and must be done to detect any asymptomatic individual in the family so he can be managed at the earliest possible time and severe complications in those patients can be avoided.
Medical Management
The medical management[1] for the patients suffering from Renal-coloboma syndrome consists of a combination of preventive as well as a curative component for the complications or the clinical manifestations happening in patients clinically. The most important component is the clinical evaluation of patient symptoms and signs. The most common evaluation involves a careful assessment of Renal and optical manifestations. The following test and workup should be done in patients if not already done to cover up all the possible aspects of clinical manifestations.
Early Evaluation
1) Evaluation of Renal structure by renal ultrasound
2) Urinalyses to look for the presence of blood and proteins
3) Evaluation of the presence of vesicoureteral reflux.
4) Measurement of renal function by renal by checking serum electrolyte concentration, creatinine, and BUN concentration levels.
4) Voiding Cystourethrogram
5) Eye and ear examination- Audiologic testing to look for the presence of hearing loss.
6) Genetic counseling
7) Team approach that usually includes ophthalmologist, nephrologist, audiologist along with clinical genetic specialist.
Prevention of complications
The prevention of complications is the most important component involved in patient care.
Most importantly focuses on the prevention of
- Development of ESRD
- Vision Loss resulting from the detachment of retinal epithelium.
Treatment for ongoing symptoms and complications
The treatment approach for patients with Renal-coloboma syndrome mainly involves the team of Nephrologists, Ophthalmologists, Audiologists. The ongoing treatment helps in the better control of symptoms and giving patients a better quality of life.
- Managing the patients for hypertension and the vesicoureteral reflux that might be affecting the long-term renal outcome and the renal function.
- This helps in preventing the development of end-stage renal disease in patients.
- ESRD if develops - dialysis, and/or renal transplantation.
- Vision experts or ophthalmologists are helpful in correcting the vision and help in the occurrence of significant vision loss.
Prevention
Prevention of secondary complications
Prevention of secondary complications is usually performed for the patients having some form of congenital abnormalities.
- If patient is having congenital optic disc abnormalities the secondary prevention is done
- close follow-up with the ophthalmologist and protective eyewear.
Avoid
Avoid the use of medications and substances that can negatively impact one's kidney function.
- A nephrologist should always be consulted before starting any medication to avoid any impairment in kidney function.
- Patients are also instructed to avoid contact sports.
Evaluation of Relatives at Risk
It is the most important component in patients with renal coloboma syndrome.
- It is acceptable to evaluate and clarify the genetic status of asymptomatic relatives of patients with Renal-coloboma syndrome.
- It is usually done with the help of genetic testing of the PAX2 pathogenic variant
- To identify asymptomatic family members so a to identify any family member that could be benefited from the therapy.