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| __NOTOC__ | | __NOTOC__ |
| | '''For patient information click [[{{PAGENAME}} (patient information)|here]]''' |
| {{DiseaseDisorder infobox | | | {{DiseaseDisorder infobox | |
| Name = Ankylosing spondylitis | | | Name = Ankylosing spondylitis | |
| ICD10 = {{ICD10|M|08|1|m|05}}, {{ICD10|M|45||m|45}} | | | ICD10 = | |
| ICD9 = {{ICD9|720.0}} | | | ICD9 = | |
| ICDO = | | | ICDO = | |
| Image = Ankylosing.jpg | | | Image = Ankylosing.jpg | |
| Caption = | | | Caption = | |
| OMIM = 106300 | | | OMIM = | |
| MedlinePlus = 000420 | | | MedlinePlus = | |
| DiseasesDB = 728 | | | DiseasesDB = | |
| MeshID = D013167 | | | MeshID = | |
| }} | | }} |
| '''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
| | {{Ankylosing spondylitis}} |
| {{Ankylosing spondylitits}} | | {{CMG}}; '''Associate Editor-In-Chief:''' {{VKG}} |
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| {{CMG}} | |
| '''Associate Editor-In-Chief:''' {{CZ}} | |
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| '''''Synonyms and keywords:''''' Ankylosing spondylitis, AS, Bechterew's disease, Bechterew syndrome, Marie Strümpell disease, Marie Struempell disease, Spondyloarthritis
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| ==Overview==
| | {{SK}} Ankylosing spondylitis, AS, Bechterew's disease, Bechterew syndrome, Marie Strümpell disease, Marie Struempell disease, Spondyloarthritis; rheumatoid spondylitis; spondylitis; spondylarthropathy |
| Ankylosing spondylitis is a chronic, painful, [[degenerative disease|degenerative]] inflammatory [[arthritis]] primarily affecting [[vertebral column|spine]] and [[sacroiliac joint]]s, causing eventual fusion of the spine; it is a member of the group of the [[autoimmune]] [[spondyloarthropathy|spondyloarthropathies]] with a probable genetic predisposition. Complete fusion results in a complete rigidity of the spine, a condition known as '''bamboo spine'''.<ref>{{cite journal | author = Jiménez-Balderas FJ, Mintz G. | title = Ankylosing spondylitis: clinical course in women and men. | journal = J Rheumatol | volume = 20 | issue = 12 | pages = 2069-72 | year = 1993 | id = PMID 7516975}}</ref> | |
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| ==Epidemiology== | | ==[[Ankylosing spondylitis overview|Overview]]== |
| The gender ratio is 3:1 for men:women. In USA, the [[prevalence]] is 0.25%, but as it is a chronic condition the [[incidence (epidemiology)|incidence]] (number of new cases) is fairly low.
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| ==Pathophysiology== | | ==[[Ankylosing spondylitis historical perspective|Historical Perspective]]== |
| AS is a systemic [[rheumatic]] disease, and is one of the seronegative spondyloarthropathies. About 90% of the patients express the [[HLA-B27]] genotype. [[Tumor necrosis factor-alpha]] (TNF α) and [[IL-1]] are also implicated in ankylosing spondylitis. Although specific autoantibodies cannot be detected, its response to immunosuppresive medication has prompted its classification as an autoimmune disease.
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| Hypotheses on its pathogenesis include a cross-reaction with antigens of the [[Klebsiella]] bacterial strain (Tiwana et al. 2001).<ref> {{cite journal | author = Tiwana H, Natt R, Benitez-Brito R, Shah S, Wilson C, Bridger S, Harbord M, Sarner M, Ebringer A | title = Correlation between the immune responses to collagens type I, III, IV and V and Klebsiella pneumoniae in patients with Crohn's disease and ankylosing spondylitis. | journal = Rheumatology (Oxford) | volume = 40 | issue = 1 | pages = 15-23 | year = 2001 | id = PMID 11157137}}</ref>
| | ==[[Ankylosing spondylitis classification|Classification]]== |
| Particular authorities argue that elimination of the prime nutrients of Klebsiella (starches) would decrease antigenemia and improve the musculoskeletal symptoms. On the other hand, Khan (2002) argues that the evidence for a correlation between Klebsiella and AS is circumstantial so far, and that the efficacy of low-starch diets has not yet been scientifically evaluated.<ref>{{cite book | author=Khan MA. | year=2002 | title=Ankylosing spondylitis: The facts | publisher= Oxford University Press | id=ISBN 0-19-263282-5}}</ref>
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| Similarly, Toivanen (1999) found no support for the role of klebsiella in the etiology of primary AS.<ref>{{cite journal | author = Toivanen P, Hansen D, Mestre F, Lehtonen L, Vaahtovuo J, Vehma M, Möttönen T, Saario R, Luukkainen R, Nissilä M | title = Somatic serogroups, capsular types, and species of fecal Klebsiella in patients with ankylosing spondylitis. | journal = J Clin Microbiol | volume = 37 | issue = 9 | pages = 2808-12 | year = 1999 | id = PMID 10449457 | url=http://jcm.asm.org/cgi/content/full/37/9/2808?view=long&pmid=10449457}}</ref>
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| ==History== | | ==[[Ankylosing spondylitis pathophysiology|Pathophysiology]]== |
| [[Image:AS trask.jpg|thumb|200px|left|Leonard Trask, the Wonderful Invalid.]] | |
| AS was probably first recognized as a disease which was different from [[Rheumatoid arthritis]] by [[Galen]] as early as the second century AD<ref>{{cite journal | author=Dieppe P | title=Did Galen describe rheumatoid arthritis? | journal=Annals of the Rheumatic Diseases | year=1988 | volume=47 | pages=84-87}}</ref>; however, skeletal evidence of the disease (ossification of joints and entheses primarily of the [[axial skeleton]], known as "bamboo spine") were first discovered in an archaeological dig that unearthed the skeletal remains of a 5000 year–old Egyptian mummy with evidence of "bamboo spine".<ref>{{cite journal | author=Calin A. | title=Ankylosing spondilitis. | journal=Clinics in Rheumatic Diseases | year=1985 | volume=11 | pages=41–60}}</ref>
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| The anatomist and surgeon Realdo Colombo described what could have been the disease in 1559,<ref>{{cite journal | author=Pierre Marie | title=Benoist M. - Historical Perspective | journal= Spine | year=1995 | volume=20 | pages=849–852}}</ref>
| | ==[[Ankylosing spondylitis causes|Causes]]== |
| and the first account of pathologic changes to the [[skeleton]] possibly associated with AS was published in 1691 by Bernard Connor.<ref>{{cite journal | author=Blumberg BS | title=? | journal=Arch Rheum | year=1958 | volume=1 | pages=553}}</ref>
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| In 1818, Benjamin Collins Brodie became the first physician to document that [[iritis]] accompanied what is believed to have been a patient with active AS.<ref>{{cite journal | author = Leden I | title = Did Bechterew describe the disease which is named after him? A question raised due to the centennial of his primary report. | journal = Scand J Rheumatol | volume = 23 | issue = 1 | pages = 42-5 | year = 1994 | id = PMID 8108667}}</ref>
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| In 1858, David Tucker published a small booklet which clearly described a patient by the name of Leonard Trask who suffered from severe spinal deformity subsequent to AS.<ref>{{cite web | title=Life and sufferings of Leonard Trask | url=http://www.asimllc.com/members/life%20and%20sufferings%20of%20leonard%20trask.pdf | format=PDF for registered members) | publisher=Ankylosing Spondylitis Information Matrix}}</ref><ref>{{cite web | title=Life and sufferings of Leonard Trask | url=http://www.showhistory.com/TraskLeonard.handicapped.html}}</ref>
| | ==[[Differentiating ankylosing spondylitis from other diseases|Differentiating Ankylosing spondylitits from other Diseases]]== |
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| In 1833 Trask fell from a horse, exacerbating the condition and resulting in severe deformity. Tucker reported that
| | ==[[Ankylosing spondylitis epidemiology and demographics|Epidemiology and Demographics]]== |
| {{cquote|It was not until he [Trask] had exercised for some time that he could perform any labor [..., and that] his neck and back have continued to curve drawing his head downward on his breast.}} evidence of inflammatory disease characteristics of AS, and the hallmark of deforming injury in AS. This account became the first documented case of AS in the United States.
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| It was not until the late nineteenth century (1893-1898), however, when the neurophysiologist [[Vladimir Bekhterev]] of Russia in 1893,<ref>{{cite journal | author=Bechterew W. | title=Steifigkeit der Wirbelsaule und ihre Verkrummung als besondere Erkrankungsform. | journal=Neurol Centralbl | year=1893 | volume=12 | pages=426–434}}</ref>
| | ==[[Ankylosing spondylitis risk factors|Risk Factors]]== |
| [[Adolph Strümpell]] of Germany in 1897,<ref>{{cite journal | author=Strumpell A. | title=Bemerkung uber die chronische ankylosirende Entzundung der Wirbelsaule und der Huftgelenke. | journal=Dtsch Z Nervenheilkd | year=1897 | volume=11 | pages=338–342}}</ref> | |
| and [[Pierre Marie]] of France in 1898,<ref>{{cite journal | author=Marie P. | title=Sur la spondylose rhizomelique. | journal=Rev Med | year=1898 | volume=18 | pages=285–315}}</ref> were the first to give adequate descriptions which permitted an accurate diagnosis of AS prior to severe spinal deformity. For this reason, AS is also known as Bechterew Disease or Marie–Strümpel Disease.
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| ==Signs and symptoms== | | ==[[Ankylosing spondylitis natural history, complications and prognosis|Natural History, Complications and Prognosis]]== |
| The typical patient is young, of 15 to 30 years of age with [[chronic (medicine)|chronic]] pain and stiffness in the lower part of the spine. Men are affected more than women by a ratio in excess of 2:1.<ref>http://www.spondylitis.org/patient_resources/women.aspx</ref> In 40% of cases, ankylosing spondylitis is associated with [[iridocyclitis]] (anterior [[uveitis]], also known as iritis) causing eye pain and [[photophobia]] (increased sensitivity to light). Other common symptoms are recurring [[mouth ulcers]] (aphthae) and [[Fatigue (physical)|fatigue]]. Pain fluctuation from one side to the other.
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| Typical [[prodrome]]s (early symptoms) may occur at a very young age (e.g. 3 years old), where the patient may experience recurring painful joints (e.g. knees, elbows), commonly misinterpreted as simple rheumatism.
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| AS is also associated with [[ulcerative colitis]], [[Crohn's disease]], [[psoriasis]], and Reiter's disease.
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| ==Diagnosis== | | ==Diagnosis== |
| [[Image:Ankylosing process.jpg|left|thumb|256px|The ankylosis process.]] | | [[Ankylosing spondylitis history and symptoms|History and Symptoms]] | [[Ankylosing spondylitis physical examination|Physical Examination]] | [[Ankylosing spondylitis laboratory findings|Laboratory Findings]] | [[Ankylosing spondylitis x ray|X Ray]] | [[Ankylosing spondylitis CT|CT]] | [[Ankylosing spondylitis MRI|MRI]] | [[Ankylosing spondylitis other imaging findings|Other Imaging Findings]] | [[Ankylosing spondylitis other diagnostic studies|Other Diagnostic Studies]] |
| There is no direct test to diagnose AS. A clinical examination and [[X-ray]] studies of the spine, which show characteristic spinal changes and [[Sacroiliac joint|sacroiliitis]], are the major diagnostic tools. A drawback of X-ray diagnosis is that signs and symptoms of AS have usually been established as long as 8-10 years prior to X-ray evident changes occurring on a plain film X-ray, which means a delay of as long as 10 years before adequate therapies can be introduced. An option for more accurate (and much earlier) diagnosis are [[Computed tomography|tomography]] and [[magnetic resonance imaging]] of the sacroiliac joints. The [[Schober's test]] is a useful clinical measure of flexion of the lumbar spine performed during examination.<ref>{{cite journal | author = Thomas E, Silman AJ, Papageorgiou AC, Macfarlane GJ, Croft PR. | title = Association between measures of spinal mobility and low back pain. An analysis of new attenders in primary care. | journal = Spine | volume = 23 | issue = 2 | pages = 343-7 | year = 1998 | id = PMID 9507623}}</ref>
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| During acute inflammatory periods, AS patients will usually show an increase in the blood concentration of [[C-Reactive protein|C-reactive protein]] (CRP) and an increase in the [[erythrocyte sedimentation rate]] (ESR).
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| Variations of the HLA-B gene increase the risk of developing ankylosing spondylitis, although it is not a diagnostic test. Those with the [[HLA-B27]] variant are at highest risk of developing the disorder. HLA-B27, demonstrated in a [[blood test]], is occasionally used as a diagnostic, but does not distinguish AS from other diseases and is therefore not of real diagnostic value. Over 95% of people with AS are HLA-B27 positive, although this ratio varies from population to population (only 50% of African American patients with AS possess HLA-B27, and it is close to 80% among AS patients from Mediterranean countries).
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| The Bath Ankylosing Spondylitis Disease Activity Index ([[BASDAI]]), developed in Bath (Somerset,UK) is an index designed to detect the inflammatory burden of active disease. The BASDA can help to establish a diagnosis of AS in the presence of other factors such as HLA-B27 positivity, persistent buttock pain which resolves with exercise, and X-ray or MRI evident involvement of the sacroiliac joints. (See: "Diagnostic Tools", below)<ref>{{cite journal | author = Garrett S, Jenkinson T, Kennedy L, Whitelock H, Gaisford P, Calin A | title = A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. | journal = J Rheumatol | volume = 21 | issue = 12 | pages = 2286-91 | year = 1994 | id = PMID 7699630}}</ref>
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| It can be easily calculated and accurately assesses a patient's need for additional therapy; a score of 4 out of a possible 10 points while on adequate NSAID therapy is usually considered a good candidate for biologic therapy.
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| The Bath Ankylosing Spondylitis Functional Index (BASFI) is a functional index which can accurately assess a patient's functional impairment due to the disease, as well as improvements following therapy. (See: "Diagnostic Tools", below)<ref>{{cite journal | author = Calin A, Garrett S, Whitelock H, Kennedy L, O'Hea J, Mallorie P, Jenkinson T | title = A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. | journal = J Rheumatol | volume = 21 | issue = 12 | pages = 2281-5 | year = 1994 | id = PMID 7699629}}</ref>
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| The BASFI is not usually used as a diagnostic tool, but as a tool to establish a patient's current baseline and subsequent response to therapy.
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| ==Diagnostic Findings==
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| * recognition of minimally displaced fractures is difficult due to osteopenia and deformity
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| * important to specifically search for disk space widening and discontinuity of the ossified paraspinal ligaments
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| * with CT, sagittal reformats should be obtained as axial images poorly assess the transverse fracture plane
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| * MR and radionuclide scintigraphy may be helpful in difficult cases
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| ===Radiograph===
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| [[Image:Morbus Bechterew.jpg|left|thumb|200px|Ankylosing spondylitis (Morbus Bechterew)]] | |
| * indistinct joints
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| * joints widen before narrow
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| * subchondral erosions, sclerosis, and proliferation on iliac side of SI joints
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| * at endstage, sacroiliac joint may be a thin line or not visible
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| * in the spine, early spondylitis is characterized by small erosions at the corners of vertebral bodies with reactive sclerosis
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| * squaring of the vertebral body
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| * syndesmophyte formation, with bridging of the corners of one vertebra to another
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| * ossification of paravertebral connective tissue fibers, including posterior interspinous ligaments as well as linking of spinous processes leads to an appearance of a solid midline vertical dense line on AP projection
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| * may see associated pseudoarthroses (discovertebral destruction with adjacent sclerosis) and enthesopathic changes (ill-defined erosions with adjacent sclerosis at sites of ligamentous and tendenous attachments)
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| * hip involvement is generally bilateral and symmetric, with uniform joint space narrowing, axial migration of the femoral head, and a collar of osteophytes at the femoral head-neck junction
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| * knees demonstrate uniform joint space narrowing with bony proliferation
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| * hands are generally involved asymmetrically, with smaller, shallower erosions and marginal periostitis.
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| * radiographs of the lungs may demonstrate progressive fibrosis and bullous changes at the apices. These lesions may resemble TB infection and bullae may become infected.
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| ===CT===
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| * may be useful in selected patients with normal or equivocal findings on sacroiliac joint radiographs
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| * joint erosions, subchondral sclerosis, and bony ankylosis are better visualized on CT
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| * some normal variants of the SI joints may mimic features of sacroiliitis
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| * CT supplements scintigraphy in evaluated areas of increased uptake
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| * multidetector CT is superior to radiographs and MRI in demonstrating injuries
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| * MDCT is imaging modality of choice in patients with advanced ankylosing spondylitis for whom there is suspicion of cervical spine fracture
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| ===MRI===
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| * May have a role in early diagnosis of sacroiliitis
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| * Synovial enhancement on MR correlates with disease activity measured by inflammatory mediators
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| * Superior to CT in detection of cartilage, bone erosions, and subchondral bone changes
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| * Increased T2 signal correlates with edema or vascularized fibrous tissue
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| * Useful in following treatment results in patients with active ankylosing spondylitis
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| ===Bone scintigraphy===
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| * May be helpful in selected patients with normal or equivocal findings on sacroiliac joint radiographs
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| * Qualitative assessment of accumulation of radionuclides in the SI joints may be difficult due to normal uptake in this location. Thus quantitative analysis may be more useful.
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| * Ratios of SI joint to sacral uptake of 1.3:1 or higher is abnormal
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| (Images courtesy of RadsWiki)
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| <gallery>
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| Image:AS-dural-ectasia-001.jpg|AS with [[dural ectasia]]
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| Image:AS-dural-ectasia-002.jpg|AS with [[dural ectasia]]
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| Image:AS-dural-ectasia-003.jpg|AS with [[dural ectasia]]
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| </gallery>
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| <gallery>
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| Image:Ankylosing-spondylitis-001.jpg|Bamboo Spine
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| Image:Ankylosing-spondylitis-002.jpg|Bamboo Spine
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| </gallery>
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| <gallery>
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| Image:Ankylosing-spondylitis-301.jpg|Symmetrical sacroiliac joint fusion
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| Image:Ankylosing-spondylitis-302.jpg|Symmetrical sacroiliac joint fusion
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| </gallery>
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| ==Therapy==
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| No cure is known for AS, although treatments and medications are available to reduce symptoms and pain.
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| Physical therapy and exercise, along with medication, are at the heart of therapy for ankylosing spondylitis. Physiotherapy and physical exercises are clearly preceded by medical treatment in order to reduce the inflammation and pain, and commonly followed by a physician. This way the movements will help in diminishing pain and stiffness, while exercises in an active inflammatory state will just make the pain worse.
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| Patients who are able to do so, lie flat on their face or back on the floor for a prescribed cumulative period of time each week, to prevent the chronic stooping which may otherwise result.<ref>{{cite web | title=Remicade.com | work=Living with Ankylosing Spondylitis | url=http://www.remicade.com/as/as_living/living_with_as.jsp | accessdate=2007-01-11}}</ref>
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| ===Medication===
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| There are three major types of medications used to treat ankylosing spondylitis.
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| * [[Non-steroidal anti-inflammatory drug|NSAID]]s such as [[aspirin]], [[ibuprofen]], [[indometacin]], [[naproxen]] and [[COX-2 inhibitor]]s, which reduce inflammation and pain. These drugs tend to have a personal response to the pain and inflammation, although commonly used anti-inflammatory drugs like [[nimesulide]] are less effective than others;
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| * [[Disease-modifying antirheumatic drug|DMARD]]s such as [[cyclosporin]], [[methotrexate]], [[sulfasalazine]], and [[corticosteroids]], used to reduce the immune system response through [[immunosuppression]];
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| * [[Tumor necrosis factor-alpha|TNFα]] blockers (antagonists) such as [[etanercept]], [[infliximab]] and [[adalimumab]] (also known as biologics), are indicated for the treatment of and are effective [[immunosuppression|immunosuppressant]]s in AS as in other autoimmune diseases;
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| [[Tumor necrosis factor-alpha|TNFα]] blockers have been shown to be the best promising treatment, slowing the progress of AS in the majority of clinical cases. They have also been shown to be highly effective in treating not only the arthritis of the joints but the spinal arthritis associated with AS. A drawback is the fact that these drugs increase the risk of infections. For this reason, the protocol for any of the TNF-α blockers include a test for tubercolosis (like [[Mantoux test|Mantoux]] or [[Heaf test|Heaf]]) before starting treatment. In case of recurrent infections, like even recurrent [[Pharyngitis|sore throats]], the therapy may be suspended due to the involved [[immunosuppression]]. | | ==Treatment== |
| | [[Ankylosing spondylitis medical therapy|Medical Therapy]] | [[Ankylosing spondylitis primary prevention|Primary Prevention]] | [[Ankylosing spondylitis secondary prevention|Secondary Prevention]] | [[Ankylosing spondylitis surgery|Surgery]] | [[Ankylosing spondylitis cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Ankylosing spondylitis future or investigational therapies|Future or Investigational Therapies]] |
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| ===Surgery=== | | ==Case Studies== |
| In severe cases of AS, [[surgery]] can be an option in the form of joint replacements, particularly in the knees and hips. Surgical correction is also possible for those with severe flexion deformities (severe downward curvature) of the spine, particularly in the neck, although this procedure is considered risky.
| | :[[Ankylosing spondylitis case study one|Case #1]] |
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| In addition, AS can have some manifestations which make anaesthesia more complex.
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| Changes in the upper airway can lead to difficulties in intubating the airway, spinal and epidural anaesthesia may be difficult due to calicification of ligaments, and a small number have aortoc insufficiency. The stiffness of the thoracic ribs results in ventilation being mainly diaphragm-driven, so there may be a decrease in pulmonary function.
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| ===[[Ankylosing Spondylitis physical therapy | Physical therapy ]]===
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| All physical therapies must be approved in advance by a rheumatologist, since movements that normally have great benefits on one's health, may harm a patient with AS: massages and physical manipulations should be practiced by therapists familiar with this disease.
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| * [[Physical therapy]] has been shown to be of great benefit to AS patients;
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| * [[Swimming]] is one of the preferred exercises since it involves all muscles and joints in a low gravity environment;
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| * Slow movements exercises like stretching, yoga, tai chi;
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| * Any physical movement like, jogging, Pilates|Pilates method, etc.
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| ===Alternative medicine===
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| Although the effectiveness of alternative medicines has not been proved by any [[clinical trial]], some patients find some relief in adding these alternative treatments to the medicaments and physical exercises, like a [[starch]] free [[Diet (nutrition)|diet]]<ref>{{cite journal | author = Ebringer A, Wilson C | title = The use of a low starch diet in the treatment of patients suffering from ankylosing spondylitis. | journal = Clin Rheumatol | volume = 15 Suppl 1 | issue = | pages = 62-66 | year = 1996 | month = Jan 15 | id = PMID 8835506}}</ref> (also known as the No Starch Diet or NSD<ref>http://www.kickas.org/ubbthreads/postlist.php?Board=starch 'No Starch Diet'</ref>). Some patients may find relief under acupuncture treatments. This is administered at various points directly on the spine where the pain is located, although efficacy is uncertain. Herbal medicine, may also relieve pain, partly due to placebo effect.<ref>http://www.nlm.nih.gov/medlineplus/news/fullstory_51426.html National Institute of Health</ref>
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| ==Prognosis==
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| AS can range from mild to progressively debilitating, and from medically controlled to refractive.
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| Unattended cases of AS normally lead to knee pain, and may be accompanied by [[dactylitis]] or [[enthesitis]], which may result in a misdiagnosis of normal rheumatism. In a long-term undiagnosed period, [[osteopenia]] or [[osteoporosis]] of AP spine may occur, causing eventual compression fractures and a back "hump" if untreated. Typical signs of progressed AS are the visible formation of syndesmophytes on X-rays, an abnormal bone outgrowth similar to osteophytes, affecting the spine. Due to the fusion of the vertrbrae [[paresthesia]] is a complication due to the inflammation of the tissue surrounding nerves.
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| Organs affected by AS, other than the axial [[vertebral column|spine]] and other joints, are commonly the [[heart]], [[lung]]s, [[Colon (anatomy)|colon]], and [[kidney]]. Other complications are [[Aortic regurgitation]], [[Achilles tendinitis]], [[Heart block|AV node block]] and [[Amyloidosis]]. Due to lung fibrosis, [[chest X-rays]] may show apical fibrosis while [[pulmonary function testing]] may reveal a restrictive lung defect. Very rare complications involve [[neurology|neurologic]] conditions such as the [[cauda equina syndrome]].<ref>{{cite journal | author = Nicholas U. Ahn, Uri M. Ahn, Elizabeth S. Garrett et al. | title = Cauda Equina Syndrome in AS (The CES-AS Syndrome): Meta-analysis of outcomes after medical and surgical treatments. | journal = J of Spinal Disorders | volume = 14 | issue = 5 | pages = 427-433 | year = 2001 | id = PMID 11586143}}</ref>
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| ==See also==
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| * [[North American Spondylitis Consortium|NASC]], North American AS federation
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| * NIAMS the National Institute of Arthritis and Musculoskeletal and Skin Diseases
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| * [[Spondylitis Association of America|SAA]], Spondylitis Association of America
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| ==References==
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| {{Reflist|2}}
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| ==Additional Reading==
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| {{refbegin|2}}
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| *Baraliakos, X, Landewé, R, Hermann, KG, et al. Inflammation in ankylosing spondylitis: a systematic description of the extent and frequency of acute spinal changes using magnetic resonance imaging. Ann Rheum Dis 2005 May; 64(5): 730-4.
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| *Bennett, D.L., Ohashi, K., El-Khoury, G.Y. Spondyloarthropathies: ankylosing spondylitis and psoriatic arthritis. Radiol Clin North Am 2004 Jan; 42(1): 121-34.
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| *Cawley, M.I., Chalmers, T.M., Kellgren, J.H., Ball, J. Destructive lesions of vertebral bodies in ankylosing spondylitis. Ann Rheum Dis 1972 Sep; 31(5): 345-58.
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| *Dihlmann, W. Current radiodiagnostic concept of ankylosing spondylitis. Skeletal Radiol 1979; 4(4): 179-88.
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| *Fam, A.G., Rubenstein, J.D., Chin-Sang, H., Leung, F.Y. Computed tomography in the diagnosis of early ankylosing spondylitis. Arthritis Rheum 1985 Aug; 28(8): 930-7.
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| *Graham, B., Van Peteghem, P.K. Fractures of the spine in ankylosing spondylitis. Diagnosis, treatment, and complications. Spine 1989 Aug; 14(8): 803-7.
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| *Hanson, J.A., and Mirza, S. Predisposition for spinal fracture in ankylosing spondylitis. AJR 2000; 174:150.
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| *Karasick, D., Schweitzer, M.E., Abidi, N.A., Cotler, J.M. Fractures of the vertebrae with spinal cord injuries in patients with ankylosing spondylitis: imaging findings. AJR Am J Roentgenol 1995 Nov; 165(5): 1205-8.
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| {{refend}}
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| ==External links==
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| ===National organizations===
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| *[http://www.asaustralia.org/ The Ankylosing Spondylitis group Australia]
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| *[http://www.spondylitis.be/ Vlaamse Vereniging voor Bechterew-Patiënten vzw Belgium]
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| *[http://www.spondilite.it/ Associazione Italiana per la Lotta alla Spondilite Anchilosante Italy]
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| *[http://www.nass.co.uk/ National Ankylosing Spondylitis Society UK]
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| *[http://www.spondylitis.org/ Spondylitis Association of America USA]
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| ===Diagnostic tools===
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| *[http://www.basdai.com/BASDAI.php Bath Ankylosing Spondylitis Disease Activity Index Calculator BASDAI]
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| *[http://www.basdai.com/BASFI.php Bath Ankylosing Spondylitis Functional Index Calculator BASFI]
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| ===Support groups===
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| *[http://www.as-assist.com/ AS-Assist]
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| *[http://www.kickas.org/ KickAS]
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| ===Current research===
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| *[http://ankylosingspondylitis.researchtoday.net/ Ankylosing Spondylitis Research]
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| *[http://www.asimllc.com/ Ankylosing Spondylitis Information Matrix]
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| {{Link FA|de}}
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| {{Diseases of the musculoskeletal system and connective tissue}} | | {{Diseases of the musculoskeletal system and connective tissue}} |
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| [[Category:Arthritis]] | | [[Category:Arthritis]] |
| [[Category:Autoimmune diseases]] | | [[Category:Autoimmune diseases]] |
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| [[cs:Bechtěrevova nemoc]] | | [[cs:Bechtěrevova nemoc]] |
| [[de:Spondylitis ankylosans]] | | [[de:Spondylitis ankylosans]] |