Lactic acidosis differential diagnosis: Difference between revisions
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==Overview== | |||
Lactic acidosis must be differentiated from other diseases that cause elevated lactate Any shock state or dysfunction of the metabolic pathway responsible for lactate clearance or production can underlie lactic acidosis. A few are: | |||
*Inborn errors of metabolism | |||
*Cardiogenic shock | |||
*Cardiogenic pulmonary edema | |||
==Differentiating Lactic acidosis from other Diseases== | |||
== Differentiating Lactic acidosis from other Diseases == | |||
Lactic acidosis should be differentiated from: | Lactic acidosis should be differentiated from: | ||
*Any shock state | *Any shock state | ||
*SIRS; lactate may be 2-5 mEq/L | *[[Systemic inflammatory response syndrome|SIRS]]; lactate may be 2-5 mEq/L | ||
*Thiamine deficiency | *[[Beriberi|Thiamine deficiency]] | ||
*Seizures | *D-lactic acidosis | ||
*[[Seizure|Seizures]] | |||
*Infarcted colon | *Infarcted colon | ||
*Hepatic failure | *[[Hepatic failure]] | ||
*Malignancy | *Malignancy | ||
*Heavy exercise | *Heavy exercise | ||
*Albuterol and other beta agonists | *Albuterol and other beta agonists | ||
*Toxicologic Causes: | *Toxicologic Causes: | ||
**Cyanide | **[[Cyanide poisoning|Cyanide]] | ||
**Carbon Monoxide | **[[Carbon monoxide|Carbon Monoxide]] | ||
**Metformin use in diabetics | **Metformin use in diabetics | ||
**Didanosine | **Didanosine | ||
| Line 29: | Line 29: | ||
**Linezolid | **Linezolid | ||
**Strychnine | **Strychnine | ||
**Rotenone (Fish Poison | **[[Rotenone]] (Fish Poison) | ||
**Phospine (rodenticide) | **Phospine (rodenticide) | ||
**INH (if patient seizes) | **INH (if patient seizes) | ||
**Valproate | **Valproate | ||
**Hydrogen Sulfide | **Hydrogen Sulfide | ||
**Nitroprusside (cyanide) | **[[Nitroprusside adverse reactions|Nitroprusside]] (cyanide) | ||
**Ricin & Castor Beans | **Ricin & Castor Beans | ||
**Propofol | **Propofol | ||
Latest revision as of 14:15, 29 November 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Saud Khan M.D.
Overview
Lactic acidosis must be differentiated from other diseases that cause elevated lactate Any shock state or dysfunction of the metabolic pathway responsible for lactate clearance or production can underlie lactic acidosis. A few are:
- Inborn errors of metabolism
- Cardiogenic shock
- Cardiogenic pulmonary edema
Differentiating Lactic acidosis from other Diseases
Lactic acidosis should be differentiated from:
- Any shock state
- SIRS; lactate may be 2-5 mEq/L
- Thiamine deficiency
- D-lactic acidosis
- Seizures
- Infarcted colon
- Hepatic failure
- Malignancy
- Heavy exercise
- Albuterol and other beta agonists
- Toxicologic Causes:
- Cyanide
- Carbon Monoxide
- Metformin use in diabetics
- Didanosine
- Stavudine
- Zidovudine
- Linezolid
- Strychnine
- Rotenone (Fish Poison)
- Phospine (rodenticide)
- INH (if patient seizes)
- Valproate
- Hydrogen Sulfide
- Nitroprusside (cyanide)
- Ricin & Castor Beans
- Propofol
- Sympathomimetics (cocaine, methamphetamine)
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