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{{Dysfunctional uterine bleeding}}
{{Dysfunctional uterine bleeding}}
{{CMG}} {{AE}} {{VVS}}
{{CMG}}; {{AE}} [[User:AroojNaz|Arooj Naz, M.B.B.S]], {{VVS}}
== Laboratory Findings ==
* Pap smear
* Peripheral smear
* [[Complete blood count]] ([[CBC]]) with differential
* [[Prolactin]]
* Clotting factor assays
* [[human chorionic gonadotropin]]
* [[Dehydroepiandrosterone-sulfate]] ([[DHEA-S]])
* [[Testosterone]]
* [[Estradiol]]
* [[Follicle stimulating hormone]] ([[FSH]])
* [[Luteinizing hormone]] ([[LH]])
* [[Thyroid stimulating hormone]] ([[TSH]])
* [[LFT]]s ([[liver function test]]s)
* [[Blood urea nitrogen]] ([[BUN]]) / [[creatinine]]
* Serum [[progesterone]]


==Overview==
Women afflicted with [[dysfunctional uterine bleeding]] commonly present with [[CBC]] changes, particularly changes in [[red blood cells]]. Significant laboratory findings may include [[coagulation]] profile changes, hormonal levels as well as [[biomedical]] markers to detect underlying [[malignancies]].
==Laboratory Findings==
A pregnancy test should be done to rule out pregnancy related complications leading to dysfunctional uterine bleeding by testing for [[human chorionic gonadotropin]].<ref name="pmid30422508">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages=  | pmid=30422508 | doi= | pmc= | url= }}</ref>
====CBC<ref name="pmid304225082">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages=  | pmid=30422508 | doi= | pmc= | url= }}</ref>====
#[[RBC]]: [[Iron deficiency anemia]] may be seen; [[Microcytic]], [[hypochromic]] anemia with [[central pallor]] and [[Target cells|target like cells]][[File:Anemia Reticulocyte red blood cell.jpeg|none|thumb|640x640px|Iron deficiency anemia; PMID: 28846348]]
#[[WBC]]: [[leukocytosis]]: normal
#[[Platelets]]: changes in platelet count may be seen if [[coagulopathy]] is the underlying cause
'''[[Coagulation|Coagulation Profile]]'''<ref name="pmid32491756">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages=  | pmid=32491756 | doi= | pmc= | url= }}</ref>
*[[Platelets]]: changes in platelet count may be seen if coagulopathy is the underlying cause
*[[PT]], [[aPTT]] and [[bleeding time]] vary depending on the underlying [[coagulopathy]]
*Normal labs indicate a lack of bleeding disorders as the underlying cause of [[DUB]]
*[[Clotting factor]] assays
'''[[Electrolyte|Electrolytes]]'''
*No significant changes
'''[[Genitourinary]] Tests'''
*[[Pap smear]]
*[[Peripheral smear]]
===[[Hormone|Hormonal Levels]]<ref name="pmid26803558">{{cite journal| author=Whitaker L, Critchley HO| title=Abnormal uterine bleeding. | journal=Best Pract Res Clin Obstet Gynaecol | year= 2016 | volume= 34 | issue=  | pages= 54-65 | pmid=26803558 | doi=10.1016/j.bpobgyn.2015.11.012 | pmc=4970656 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26803558  }}</ref>===
*[[TSH]]
*[[Prolactin]]
*[[Dehydroepiandrosterone-sulfate]] ([[DHEA-S]])
*[[Testosterone]]
*[[Estradiol]]
*[[Follicle stimulating hormone]] ([[FSH]])
*[[Luteinizing hormone]] ([[LH]])
*Serum [[progesterone]]
===Biomedical Markers<ref name="pmid32965984">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages=  | pmid=32965984 | doi= | pmc= | url= }}</ref>===
Markers may be helpful in diagnosing an underlying endometrial malignancy. These include:
*[[Carbohydrate antigen 125]] (CA 125)
*[[Estrogen and progesterone receptor]] expression
*Presence of [[mutations]] (e.g., [[PTEN (gene)|PTEN]], [[TP53]])
*[[E-cadherin]] (CDH1)
*Neural cell adhesion molecule L1 ([[L1CAM]])
<br />
==References==
==References==
{{reflist|2}}
{{reflist|2}}
{{WH}}
{{WH}}
{{WS}}
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[[Category:Needs content]]
[[Category:Needs content]]
[[Category:Primary care]]
[[Category:Disease]]
[[Category:Disease]]
[[Category:Gynecology]]
[[Category:Gynecology]]

Latest revision as of 00:28, 19 March 2022

Dysfunctional uterine bleeding Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Arooj Naz, M.B.B.S, Vishnu Vardhan Serla M.B.B.S. [2]

Overview

Women afflicted with dysfunctional uterine bleeding commonly present with CBC changes, particularly changes in red blood cells. Significant laboratory findings may include coagulation profile changes, hormonal levels as well as biomedical markers to detect underlying malignancies.

Laboratory Findings

A pregnancy test should be done to rule out pregnancy related complications leading to dysfunctional uterine bleeding by testing for human chorionic gonadotropin.[1]

CBC[2]

  1. RBC: Iron deficiency anemia may be seen; Microcytic, hypochromic anemia with central pallor and target like cells
    Iron deficiency anemia; PMID: 28846348
  2. WBC: leukocytosis: normal
  3. Platelets: changes in platelet count may be seen if coagulopathy is the underlying cause

Coagulation Profile[3]

Electrolytes

  • No significant changes

Genitourinary Tests

Hormonal Levels[4]

Biomedical Markers[5]

Markers may be helpful in diagnosing an underlying endometrial malignancy. These include:


References

  1. ↑ "StatPearls".   ( ). 2022:  . PMID 30422508.
  2. ↑ "StatPearls".   ( ). 2022:  . PMID 30422508.
  3. ↑ "StatPearls". 2022. PMID 32491756 Check |pmid= value (help).
  4. ↑ Whitaker L, Critchley HO (2016). "Abnormal uterine bleeding". Best Pract Res Clin Obstet Gynaecol. 34 ( ): 54–65. doi:10.1016/j.bpobgyn.2015.11.012. PMC 4970656. PMID 26803558.
  5. ↑ "StatPearls".   ( ). 2022:  . PMID 32965984 Check |pmid= value (help).

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