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[[Image:Stage of liver damage.JPG|left|Different stages of liver damage]]
[[Image:Stage of liver damage.JPG|left|Different stages of liver damage]]
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== Complications ==
== Complications ==
Up to 10% of cirrhotic alcoholic FLD will develop [[hepatocellular carcinoma]]. Overall incidence of liver cancer in non-alcoholic FLD has not been assessed yet but the association is well established.<ref>{{cite journal |author=Qian Y, Fan JG |title=Obesity, fatty liver and liver cancer |journal=HBPD INT |volume=4 |issue=2 |pages=173-7 |year=2005 |pmid=15908310 |doi=}}</ref>
Up to 10% of cirrhotic alcoholic FLD will develop [[hepatocellular carcinoma]]. Overall incidence of liver cancer in non-alcoholic FLD has not been assessed yet but the association is well established.<ref>{{cite journal |author=Qian Y, Fan JG |title=Obesity, fatty liver and liver cancer |journal=HBPD INT |volume=4 |issue=2 |pages=173-7 |year=2005 |pmid=15908310 |doi=}}</ref>
A retrospective [[cohort study]] concluded that [[liver failure]] is the main cause of morbidity and mortality in NASH-associated cirrhosis. The prognosis is either similar or less severe than HCV-cirrhosis.<ref name="pmid12883486">{{cite journal |author=Hui JM, Kench JG, Chitturi S, ''et al'' |title=Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C |journal=Hepatology |volume=38 |issue=2 |pages=420–7 |year=2003 |pmid=12883486 |doi=10.1053/jhep.2003.50320}}</ref>
* http://nafldscore.com/


==Prognosis==
==Prognosis==
A retrospective [[cohort study]] concluded that <nowiki>[[liver failure]]</nowiki> is the main cause of morbidity and mortality in NASH-associated cirrhosis. The prognosis is either similar or less severe than HCV-cirrhosis.<ref name="pmid12883486">{{cite journal |author=Hui JM, Kench JG, Chitturi S, ''et al'' |title=Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C |journal=Hepatology |volume=38 |issue=2 |pages=420–7 |year=2003 |pmid=12883486 |doi=10.1053/jhep.2003.50320}}</ref>
Prognosis can be determined by:
* http://nafldscore.com/
* FIB-4
* Liver stiffness measurement
** Vibration-controlled elastography (VCTE), Fibroscan
 
** Magnetic resonance elastography (MRE)


==References==
==References==

Latest revision as of 04:00, 2 June 2023

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Natural History

Different stages of liver damage
Different stages of liver damage


Complications

Up to 10% of cirrhotic alcoholic FLD will develop hepatocellular carcinoma. Overall incidence of liver cancer in non-alcoholic FLD has not been assessed yet but the association is well established.[1]

A retrospective cohort study concluded that liver failure is the main cause of morbidity and mortality in NASH-associated cirrhosis. The prognosis is either similar or less severe than HCV-cirrhosis.[2]

Prognosis

Prognosis can be determined by:

  • FIB-4
  • Liver stiffness measurement
    • Vibration-controlled elastography (VCTE), Fibroscan
    • Magnetic resonance elastography (MRE)

References

  1. Qian Y, Fan JG (2005). "Obesity, fatty liver and liver cancer". HBPD INT. 4 (2): 173–7. PMID 15908310.
  2. Hui JM, Kench JG, Chitturi S; et al. (2003). "Long-term outcomes of cirrhosis in nonalcoholic steatohepatitis compared with hepatitis C". Hepatology. 38 (2): 420–7. doi:10.1053/jhep.2003.50320. PMID 12883486.