Beta-thalassemia epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
The prevalence of beta-thalassemia carrier is 1.5% of the world population which is mainly in regions with a historical association with [[malaria]], including the Mediterranean, Middle East, Central Asia, Indian subcontinent, and parts of Southeast Asia and Africa. The incidence of beta-thalassemia is 42,000 per year. It affects both males and females in a similar demographic manner. | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
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There are insufficient data about the exact prevalence of beta-thalassemia. | There are insufficient data about the exact prevalence of beta-thalassemia. | ||
*The prevalence of beta-thalassemia carrier is 1.5% of the world population.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> | *The prevalence of beta-thalassemia carrier is 1.5% of the world population.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> | ||
*More than 90% of the cases live in a geographic "belt" extending from the Mediterranean basin and parts of Africa, throughout the Middle East, the Indian subcontinent, Southeast Asia, and Melanesia | *More than 90% of the cases live in a geographic "belt" extending from the Mediterranean basin and parts of Africa, throughout the Middle East, the Indian subcontinent, Southeast Asia, and Melanesia into the Pacific Islands (regions with a historical association with [[malaria]]).<ref name="pmid23331260">{{cite journal |vauthors=Ladis V, Karagiorga-Lagana M, Tsatra I, Chouliaras G |title=Thirty-year experience in preventing haemoglobinopathies in Greece: achievements and potentials for optimisation |journal=Eur J Haematol |volume=90 |issue=4 |pages=313–22 |date=April 2013 |pmid=23331260 |doi=10.1111/ejh.12076 |url=}}</ref><ref name="pmid25058394">{{cite journal |vauthors=Kountouris P, Lederer CW, Fanis P, Feleki X, Old J, Kleanthous M |title=IthaGenes: an interactive database for haemoglobin variations and epidemiology |journal=PLoS One |volume=9 |issue=7 |pages=e103020 |date=2014 |pmid=25058394 |pmc=4109966 |doi=10.1371/journal.pone.0103020 |url=}}</ref> | ||
the Pacific Islands.<ref name="pmid23331260">{{cite journal |vauthors=Ladis V, Karagiorga-Lagana M, Tsatra I, Chouliaras G |title=Thirty-year experience in preventing haemoglobinopathies in Greece: achievements and potentials for optimisation |journal=Eur J Haematol |volume=90 |issue=4 |pages=313–22 |date=April 2013 |pmid=23331260 |doi=10.1111/ejh.12076 |url=}}</ref><ref name="pmid25058394">{{cite journal |vauthors=Kountouris P, Lederer CW, Fanis P, Feleki X, Old J, Kleanthous M |title=IthaGenes: an interactive database for haemoglobin variations and epidemiology |journal=PLoS One |volume=9 |issue=7 |pages=e103020 |date=2014 |pmid=25058394 |pmc=4109966 |doi=10.1371/journal.pone.0103020 |url=}}</ref> | *There are increases in the number of cases through North America and Europe, which reflects the increased rates of migrations, refugees and adaptation of children.<ref name="pmid31233463">{{cite journal |vauthors=Barry RM, Chretien C, Kirby M, Gallant G, Leppington S, Robitaille N, Corriveau-Bourque C, Stoffman J, Wu J, Leaker M, Klaassen RJ |title=Syrian Refugees and Their Impact on Health Service Delivery in the Pediatric Hematology/Oncology Clinics Across Canada |journal=J Pediatr Hematol Oncol |volume=42 |issue=2 |pages=e107–e109 |date=March 2020 |pmid=31233463 |doi=10.1097/MPH.0000000000001524 |url=}}</ref> | ||
*Gender distribution: It affects both males and females in a similar demographic manner. Lahiry P, Al-Attar SA, Hegele RA. Understanding beta-thalassemia with a focus on the Indian subcontinent and the Middle East. The open hematology journal. 2008 Jan 22;2(1). | |||
===Incident=== | ===Incident=== | ||
*The incidence of beta-thalassemia is 42,000 per year.<ref name="pmid27390837">{{cite journal| author=Liaska A, Petrou P, Georgakopoulos CD, Diamanti R, Papaconstantinou D, Kanakis MG et al.| title=β-Thalassemia and ocular implications: a systematic review. | journal=BMC Ophthalmol | year= 2016 | volume= 16 | issue= | pages= 102 | pmid=27390837 | doi=10.1186/s12886-016-0285-2 | pmc=4938965 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27390837 }} </ref> | *The incidence of beta-thalassemia is 42,000 per year.<ref name="pmid27390837">{{cite journal| author=Liaska A, Petrou P, Georgakopoulos CD, Diamanti R, Papaconstantinou D, Kanakis MG et al.| title=β-Thalassemia and ocular implications: a systematic review. | journal=BMC Ophthalmol | year= 2016 | volume= 16 | issue= | pages= 102 | pmid=27390837 | doi=10.1186/s12886-016-0285-2 | pmc=4938965 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27390837 }} </ref> | ||
*Recent studies suggest that around 23000 infants with beta-thalassemia major are born every year and up to 90% of these infants are in low or middle-income countries.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> | *Recent studies suggest that around 23000 infants with beta-thalassemia major are born every year and up to 90% of these infants are in low- or middle-income countries.<ref name="pmid28293406">{{cite journal| author=De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M et al.| title=β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint. | journal=Mediterr J Hematol Infect Dis | year= 2017 | volume= 9 | issue= 1 | pages= e2017018 | pmid=28293406 | doi=10.4084/MJHID.2017.018 | pmc=5333734 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28293406 }} </ref> | ||
==References== | ==References== | ||
Latest revision as of 05:53, 25 August 2023
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
The prevalence of beta-thalassemia carrier is 1.5% of the world population which is mainly in regions with a historical association with malaria, including the Mediterranean, Middle East, Central Asia, Indian subcontinent, and parts of Southeast Asia and Africa. The incidence of beta-thalassemia is 42,000 per year. It affects both males and females in a similar demographic manner.
Epidemiology and Demographics
Prevalence
There are insufficient data about the exact prevalence of beta-thalassemia.
- The prevalence of beta-thalassemia carrier is 1.5% of the world population.[1]
- More than 90% of the cases live in a geographic "belt" extending from the Mediterranean basin and parts of Africa, throughout the Middle East, the Indian subcontinent, Southeast Asia, and Melanesia into the Pacific Islands (regions with a historical association with malaria).[2][3]
- There are increases in the number of cases through North America and Europe, which reflects the increased rates of migrations, refugees and adaptation of children.[4]
- Gender distribution: It affects both males and females in a similar demographic manner. Lahiry P, Al-Attar SA, Hegele RA. Understanding beta-thalassemia with a focus on the Indian subcontinent and the Middle East. The open hematology journal. 2008 Jan 22;2(1).
Incident
- The incidence of beta-thalassemia is 42,000 per year.[5]
- Recent studies suggest that around 23000 infants with beta-thalassemia major are born every year and up to 90% of these infants are in low- or middle-income countries.[1]
References
- ↑ 1.0 1.1 De Sanctis V, Kattamis C, Canatan D, Soliman AT, Elsedfy H, Karimi M; et al. (2017). "β-Thalassemia Distribution in the Old World: an Ancient Disease Seen from a Historical Standpoint". Mediterr J Hematol Infect Dis. 9 (1): e2017018. doi:10.4084/MJHID.2017.018. PMC 5333734. PMID 28293406.
- ↑ Ladis V, Karagiorga-Lagana M, Tsatra I, Chouliaras G (April 2013). "Thirty-year experience in preventing haemoglobinopathies in Greece: achievements and potentials for optimisation". Eur J Haematol. 90 (4): 313–22. doi:10.1111/ejh.12076. PMID 23331260.
- ↑ Kountouris P, Lederer CW, Fanis P, Feleki X, Old J, Kleanthous M (2014). "IthaGenes: an interactive database for haemoglobin variations and epidemiology". PLoS One. 9 (7): e103020. doi:10.1371/journal.pone.0103020. PMC 4109966. PMID 25058394.
- ↑ Barry RM, Chretien C, Kirby M, Gallant G, Leppington S, Robitaille N, Corriveau-Bourque C, Stoffman J, Wu J, Leaker M, Klaassen RJ (March 2020). "Syrian Refugees and Their Impact on Health Service Delivery in the Pediatric Hematology/Oncology Clinics Across Canada". J Pediatr Hematol Oncol. 42 (2): e107–e109. doi:10.1097/MPH.0000000000001524. PMID 31233463.
- ↑ Liaska A, Petrou P, Georgakopoulos CD, Diamanti R, Papaconstantinou D, Kanakis MG; et al. (2016). "β-Thalassemia and ocular implications: a systematic review". BMC Ophthalmol. 16: 102. doi:10.1186/s12886-016-0285-2. PMC 4938965. PMID 27390837.