Hitachimycin: Difference between revisions
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'''Hitachimycin''', also known as '''stubomycin''', is a [[Cyclic compound|cyclic]] [[polypeptide]] produced by ''[[Streptomyces]]'' that acts as an [[antibiotic]]. It exhibits cytotoxic activity against mammalian cells, [[Gram-positive]] bacteria, [[yeast]], and [[fungi]], as well as [[hemolysis|hemolytic]] activity; this is mediated by changes at the [[cell membrane]] and subsequent [[lysis]].<ref>{{cite journal |author=Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I |title=Studies on the biological activity of stubomycin |journal=J. Antibiot. |volume=36 |issue=3 |pages=301-11 |year=1983 |pmid=6833150 |doi=}}</ref> Owing to its cytotoxic activity against mammalian cells and [[tumor]]s, it was first proposed as a [[Antineoplastic|antitumor antibiotic]].<ref>{{cite journal |author=Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M |title=A new antitumor antibiotic, stubomycin |journal=J. Antibiot. |volume=34 |issue=3 |pages=259-65 |year=1981 |pmid=7275806 |doi=}}</ref> | '''Hitachimycin''', also known as '''stubomycin''', is a [[Cyclic compound|cyclic]] [[polypeptide]] produced by ''[[Streptomyces]]'' that acts as an [[antibiotic]]. It exhibits cytotoxic activity against mammalian cells, [[Gram-positive]] bacteria, [[yeast]], and [[fungi]], as well as [[hemolysis|hemolytic]] activity; this is mediated by changes at the [[cell membrane]] and subsequent [[lysis]].<ref>{{cite journal |author=Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I |title=Studies on the biological activity of stubomycin |journal=J. Antibiot. |volume=36 |issue=3 |pages=301-11 |year=1983 |pmid=6833150 |doi=}}</ref> Owing to its cytotoxic activity against mammalian cells and [[tumor]]s, it was first proposed as a [[Antineoplastic|antitumor antibiotic]].<ref>{{cite journal |author=Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M |title=A new antitumor antibiotic, stubomycin |journal=J. Antibiot. |volume=34 |issue=3 |pages=259-65 |year=1981 |pmid=7275806 |doi=}}</ref> | ||
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Latest revision as of 16:01, 9 August 2012
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| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
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| Formula | C29H35NO5 |
| Molar mass | 477.592 g/mol |
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Hitachimycin, also known as stubomycin, is a cyclic polypeptide produced by Streptomyces that acts as an antibiotic. It exhibits cytotoxic activity against mammalian cells, Gram-positive bacteria, yeast, and fungi, as well as hemolytic activity; this is mediated by changes at the cell membrane and subsequent lysis.[1] Owing to its cytotoxic activity against mammalian cells and tumors, it was first proposed as a antitumor antibiotic.[2]
As of 2007, it has not been used in a clinical setting.
References
- ↑ Komiyama K, Edanami K, Tanoh A, Yamamoto H, Umezawa I (1983). "Studies on the biological activity of stubomycin". J. Antibiot. 36 (3): 301–11. PMID 6833150.
- ↑ Umezawa I, Takeshima H, Komiyama K, Koh Y, Yamamoto H, Kawaguchi M (1981). "A new antitumor antibiotic, stubomycin". J. Antibiot. 34 (3): 259–65. PMID 7275806.
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