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{{CMG}}; {{AE}} [[User:Rim Halaby|Rim Halaby]]
{{CMG}}; {{AE}} [[User:Rim Halaby|Rim Halaby]]


==Overview==
{{Statin induced myopathy}}


==Definition==
==[[Statin induced myopathy overview|Overview]]==
Statin induced myopathy is a spectrum of muscular problems caused by the intake of statin. Myopathy by definition is the abnormal function of the muscle.
The spectrum of statin induced myopathy includes:
====Myalgia====
* Myalgia is defined as one or combination of muscle weakness, tenderness or pain.
* Patients usually complain of cramping feeling in the muscles.
* Creatine kinase may be normal or minimally elevated.


====Asymptomatic increase in creatine kinase====
==[[Statin induced myopathy classification|Classification]]==
====Myositis====
* Myositis is the inflammation of the muscle characterised by muscular complaints in the setting of elevated creatine kinase up to ten folds.


====Rhabdomyositis====
==[[Statin induced myopathy pathophysiology|Pathophysiology]]==
* Rhabdomyositis is the acute degeneration of the skeletal muscle.
* It is a potentially lethal condition due to its associated nephrotoxicity caused by myoglobinuria and myoglobinemia.
* Creatine kinase is elevated in rhabdomyosistis similarly to myositis.
* The complications of rhabdomyositis are acute tubular necrosis, hypocalcemia, hyperkalemia, metabolic acidosis, hyperuricemia, DIC and cardiomyopathy.<ref name="baker">Baker, S.K. & Tarnopolsky, M.A. (2001). Statin myopathies: pathophysiologic and clinical perspectives. Clin. Invest. Med., 24(5): 258-272.</ref>


====Other Statin Induced Myopathies====
==[[Statin induced myopathy epidemiology and demographics|Epidemiology & Demographics]]==
* Elevated creatine kinase after statin withdrawal<ref name="pmid12672737">{{cite journal| author=Thompson PD, Clarkson P, Karas RH| title=Statin-associated myopathy. | journal=JAMA | year= 2003 | volume= 289 | issue= 13 | pages= 1681-90 | pmid=12672737 | doi=10.1001/jama.289.13.1681 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12672737  }} </ref>
* Autoimmune myopathy requiring immunosuppressive therapy<ref name="pmid18367041">{{cite journal| author=Radcliffe KA, Campbell WW| title=Statin myopathy. | journal=Curr Neurol Neurosci Rep | year= 2008 | volume= 8 | issue= 1 | pages= 66-72 | pmid=18367041 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18367041  }} </ref>


==Prevalence==
==[[Statin induced myopathy epidemiology and demographics|Risk Factors]]==


==Risk Factors==
==[[Statin induced myopathy screening|Screening]]==


==Pathophysiology==
==[[Statin induced myopathy differential diagnosis|Differentiating Statin induced myopathy from other Diseases]]==


==Diagnosis==
[[Statin induced myopathy history and symptoms|History & Symptoms]] | [[Statin induced myopathy laboratory tests|Lab Tests]]
==Treatment==
==Treatment==
[[Statin induced myopathy medical therapy|Medical Therapy]]


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Cardiology]]
[[Category:Drugs]]
[[Category:Disease]]
[[Category:Up-To-Date cardiology]]
[[Category:Up-To-Date]]

Latest revision as of 16:18, 30 November 2012

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby

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