Cefamandole description: Difference between revisions

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==Description==
==Description==


Mandol® (Cefamandol (cefamandole) e Nafate for Injection, USP) is a semisynthetic broad-spectrum cephalosporin antibiotic for parenteraladministration. It is 5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1 H -tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, [6 R- [6(alpha),7(beta)( R *)]]. Cefamandol (cefamandole) e has the empirical formula C 19 H 17 N 6 NaO 6S 2 representing a molecular weight of 512.49.
Mandol® (Cefamandol (cefamandole) Nafate for Injection, USP) is a semisynthetic broad-spectrum cephalosporin antibiotic for parenteral administration. It is 5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1 H -tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, [6 R- [6(alpha),7(beta)( R *)]]. Cefamandol (cefamandole) has the empirical formula C 19 H 17 N 6 NaO 6S 2 representing a molecular weight of 512.49.


Mandol (cefamandole) also contains 63 mg sodium carbonate/g of cefamandol (cefamandole) e activity. The total sodium content is approximately 77 mg (3.3 mEq sodium ion) per g of cefamandole activity. After addition of diluent, cefamandole nafate rapidly hydrolyzes to cefamandol (cefamandole) e, and both compounds have microbiologic activity in vivo. Solutions of Mandol (cefamandole) range from light-yellow to amber, depending on concentration and diluent used. The pH of freshly reconstituted solutions usually ranges from 6.0 to 8.5.<ref name="www.rxlist.com">{{Cite web  | last =  | first =  | title = http://www.rxlist.com/mandol-drug.htm | url = http://www.rxlist.com/mandol-drug.htm | publisher =  | date =  |accessdate = }}</ref>
Mandol (cefamandole) also contains 63 mg sodium carbonate/g of cefamandol (cefamandole) activity. The total sodium content is approximately 77 mg (3.3 mEq sodium ion) per g of cefamandole activity. After addition of diluent, cefamandole nafate rapidly hydrolyzes to cefamandol (cefamandole), and both compounds have microbiologic activity in vivo.
 
Solutions of Mandol (cefamandole) range from light-yellow to amber, depending on concentration and diluent used. The pH of freshly reconstituted solutions usually ranges from 6.0 to 8.5.<ref name="www.rxlist.com">{{Cite web  | last =  | first =  | title = http://www.rxlist.com/mandol-drug.htm | url = http://www.rxlist.com/mandol-drug.htm | publisher =  | date =  |accessdate = }}</ref>


==References==
==References==

Latest revision as of 00:13, 6 January 2014

Cefamandole
MANDOL® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Description

Mandol® (Cefamandol (cefamandole) Nafate for Injection, USP) is a semisynthetic broad-spectrum cephalosporin antibiotic for parenteral administration. It is 5-thia-1-azabicyclo [4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(formyloxy)phenylacetyl]amino]-3-[[(1-methyl-1 H -tetrazol-5-yl)thio]methyl]-8-oxo-, monosodium salt, [6 R- [6(alpha),7(beta)( R *)]]. Cefamandol (cefamandole) has the empirical formula C 19 H 17 N 6 NaO 6S 2 representing a molecular weight of 512.49.

Mandol (cefamandole) also contains 63 mg sodium carbonate/g of cefamandol (cefamandole) activity. The total sodium content is approximately 77 mg (3.3 mEq sodium ion) per g of cefamandole activity. After addition of diluent, cefamandole nafate rapidly hydrolyzes to cefamandol (cefamandole), and both compounds have microbiologic activity in vivo.

Solutions of Mandol (cefamandole) range from light-yellow to amber, depending on concentration and diluent used. The pH of freshly reconstituted solutions usually ranges from 6.0 to 8.5.[1]

References

  1. "http://www.rxlist.com/mandol-drug.htm". External link in |title= (help)

Adapted from the FDA Package Insert.