Quinine Sulfate contraindications: Difference between revisions
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(Created page with "__NOTOC__ {{Quinine Sulfate}} {{CMG}}; {{AE}} {{chetan}} ==Contraindications== QUALAQUIN is contraindicated in patients with the following: *Prolonged QT interval. One case...") |
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**Blackwater fever (acute intravascular hemolysis, hemoglobinuria, and hemoglobinemia) | **Blackwater fever (acute intravascular hemolysis, hemoglobinuria, and hemoglobinemia) | ||
*Known hypersensitivity to mefloquine or quinidine: cross-sensitivity to quinine has been documented [see Warnings and Precautions | *Known hypersensitivity to mefloquine or quinidine: cross-sensitivity to quinine has been documented [see Warnings and Precautions ]. | ||
**Myasthenia gravis. Quinine has neuromuscular blocking activity, and may exacerbate muscle weakness. | **Myasthenia gravis. Quinine has neuromuscular blocking activity, and may exacerbate muscle weakness. | ||
**Optic neuritis. Quinine may exacerbate active optic neuritis [see Adverse Reactions | **Optic neuritis. Quinine may exacerbate active optic neuritis [see Adverse Reactions].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = QUALAQUIN (QUININE SULFATE) CAPSULE [AR SCIENTIFIC INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1f66fba7-4026-4504-918d-4c88f2835cc0#nlm34089-3 | publisher = | date = | accessdate = }}</ref> | ||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = QUALAQUIN (QUININE SULFATE) CAPSULE [AR SCIENTIFIC INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1f66fba7-4026-4504-918d-4c88f2835cc0#nlm34089-3 | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Latest revision as of 22:47, 9 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]
Contraindications
QUALAQUIN is contraindicated in patients with the following:
- Prolonged QT interval. One case of a fatal ventricular arrhythmia was reported in an elderly patient with a prolonged QT interval at baseline, who received quinine sulfate intravenously for P. falciparum malaria [see Warnings and Precautions].
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
- Hemolysis can occur in patients with G6PD deficiency receiving quinine.
- Known hypersensitivity reactions to quinine.
- These include, but are not limited to, the following [see Warnings and Precautions}
- Thrombocytopenia
- Idiopathic thrombocytopenia purpura (ITP) and Thrombotic thrombocytopenic purpura (TTP)
- Hemolytic uremic syndrome (HUS)
- Blackwater fever (acute intravascular hemolysis, hemoglobinuria, and hemoglobinemia)
- Known hypersensitivity to mefloquine or quinidine: cross-sensitivity to quinine has been documented [see Warnings and Precautions ].
- Myasthenia gravis. Quinine has neuromuscular blocking activity, and may exacerbate muscle weakness.
- Optic neuritis. Quinine may exacerbate active optic neuritis [see Adverse Reactions].[1]
References
Adapted from the FDA Package Insert.