Pilomatricoma: Difference between revisions
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=====Face===== | =====Face===== | ||
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Image:Pilomatricoma01.jpg|Pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ | Image:Pilomatricoma01.jpg|Pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL> | ||
Image:Pilomatricoma02.jpg|Pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ | Image:Pilomatricoma02.jpg|Pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL> | ||
Image:Pilomatricoma03.jpg|Pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL> | |||
</gallery> | |||
=====Perforanting Pilomatricoma===== | |||
======Face====== | |||
<gallery> | |||
Image:Perforanting pilomatricoma01.jpg|Perforanting pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL> | |||
Image:Perforanting pilomatricoma02.jpg|Perforanting pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL> | |||
Image:Perforanting pilomatricoma03.jpg|Perforanting pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL> | |||
Image:Perforanting pilomatricoma04.jpg|Perforanting pilomatricoma. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/ With permission from Dermatology Atlas.]''<ref name="Dermatology Atlas">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/}}</ref></SMALL></SMALL> | |||
Latest revision as of 19:26, 30 July 2015
| Pilomatricoma | |
| Micrograph of a pilomatricoma showing the characteristic "ghost" cells (anucleate squamous cells), benign viable squamous cells and multi-nucleated giant cells. H&E stain. | |
| ICD-10 | D23 |
| DiseasesDB | 32128 |
| eMedicine | article/1058965 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]
Overview
Pilomatricoma, also known as a calcifying epithelioma of Malherbe,[1] Malherbe calcifying epithelioma, and Pilomatrixoma, is a benign skin tumor derived from the hair matrix.[2]:670[3]
Histologic features
Pilomatricomas consist of anucleate squamous cells (called "ghost cells"), benign viable squamous cells and multi-nucleated giant cells. The presence of calcifications is common.
Pathogenesis
Pilomatricoma is associated with high levels of beta-catenin caused by either a mutation in the APC gene or beta-catenin gene. These high levels of beta-catenin can aid cell proliferation, inhibit cell death, and ultimately lead to cancer.[4]
Diagnosis
Physical Examination
Skin
Face
-
![Pilomatricoma. With permission from Dermatology Atlas.[5]](/images/2/27/Pilomatricoma01.jpg)
Pilomatricoma. With permission from Dermatology Atlas.[5] -
![Pilomatricoma. With permission from Dermatology Atlas.[5]](/images/c/c3/Pilomatricoma02.jpg)
Pilomatricoma. With permission from Dermatology Atlas.[5] -
![Pilomatricoma. With permission from Dermatology Atlas.[5]](/images/c/c3/Pilomatricoma03.jpg)
Pilomatricoma. With permission from Dermatology Atlas.[5]
![Pilomatricoma. With permission from Dermatology Atlas.[5]](/index.php/File:Pilomatricoma01.jpg)
![Pilomatricoma. With permission from Dermatology Atlas.[5]](/index.php/File:Pilomatricoma02.jpg)
![Pilomatricoma. With permission from Dermatology Atlas.[5]](/index.php/File:Pilomatricoma03.jpg)
Perforanting Pilomatricoma
Face
-
![Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]](/images/7/70/Perforanting_pilomatricoma01.jpg)
Perforanting pilomatricoma. With permission from Dermatology Atlas.[5] -
![Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]](/images/8/81/Perforanting_pilomatricoma02.jpg)
Perforanting pilomatricoma. With permission from Dermatology Atlas.[5] -
![Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]](/images/6/60/Perforanting_pilomatricoma03.jpg)
Perforanting pilomatricoma. With permission from Dermatology Atlas.[5] -
![Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]](/images/1/1a/Perforanting_pilomatricoma04.jpg)
Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]
![Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]](/index.php/File:Perforanting_pilomatricoma01.jpg)
![Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]](/index.php/File:Perforanting_pilomatricoma02.jpg)
![Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]](/index.php/File:Perforanting_pilomatricoma03.jpg)
![Perforanting pilomatricoma. With permission from Dermatology Atlas.[5]](/index.php/File:Perforanting_pilomatricoma04.jpg)
See also
- Malignant pilomatricoma
- List of cutaneous conditions
- List of cutaneous neoplasms associated with systemic syndromes
References
- ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
- ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ↑ Levy J, Ilsar M, Deckel Y, Maly A, Anteby I, Pe'er J (2008). "Eyelid pilomatrixoma: a description of 16 cases and a review of the literature". Surv Ophthalmol. 53 (5): 526–35. doi:10.1016/j.survophthal.2008.06.007. PMID 18929763.
- ↑ Hassanein AM, Glanz SM, Kessler HP, Eskin TA, Liu C (2003). "beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst". Am J Clin Pathol (5):732-6. PMID 14608900.
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 "Dermatology Atlas".