Systemic lupus erythematosus causes: Difference between revisions
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{{Systemic lupus erythematosus}} | {{Systemic lupus erythematosus}} | ||
{{CMG}}; {{AE}} {{RT}} | {{CMG}}; {{AE}} {{MIR}} {{RT}} | ||
==Overview== | |||
There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include [[genetic]] predisposition, [[Auto-immune disease|auto-immune diseases]], and use of drugs. Less common factors include environmental factors and exposure to [[Ultraviolet light|ultraviolet (UV) light.]] | |||
==Causes== | |||
* [[Genetic]] predisposition:<ref name="pmid8749564">{{cite journal |vauthors=Schur PH |title=Genetics of systemic lupus erythematosus |journal=Lupus |volume=4 |issue=6 |pages=425–37 |year=1995 |pmid=8749564 |doi=10.1177/096120339500400603 |url=}}</ref> | |||
**[[HLA]] class [[polymorphism]] | |||
** [[Complement]] genes | |||
** Female sexual gene due to high levels of [[estrogen]] and [[prolactin]] | |||
* [[Auto-immune]] disease<ref name="pmid7656468">{{cite journal |vauthors=Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT |title=Estrogens, the immune response and autoimmunity |journal=Clin. Exp. Rheumatol. |volume=13 |issue=2 |pages=217–26 |year=1995 |pmid=7656468 |doi= |url=}}</ref> | |||
* Infections | |||
** [[Parvovirus B19]] | |||
** [[Epstein-Barr virus|Epstein-Barr virus (EBV)]] | |||
* | ** [[Trypanosomiasis]] | ||
* | ** [[Mycobacterial infection|Mycobacterial infections]] | ||
* | |||
** [[ | * Exposure to [[ultraviolet]] (UV) light<ref name="pmid12464374">{{cite journal |vauthors=Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS |title=Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history |journal=J Clin Epidemiol |volume=55 |issue=10 |pages=982–9 |year=2002 |pmid=12464374 |doi= |url=}}</ref> | ||
** [[ | ** Can exacerbate or induce systemic manifestations of SLE | ||
** [[ | * Drug-induced lupus | ||
* | |||
** | |||
* | |||
==References== | ==References== | ||
Latest revision as of 12:58, 17 October 2019
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Systemic lupus erythematosus Microchapters |
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Differentiating Systemic lupus erythematosus from other Diseases |
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Systemic lupus erythematosus causes On the Web |
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Risk calculators and risk factors for Systemic lupus erythematosus causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mahshid Mir, M.D. [2] Raviteja Guddeti, M.B.B.S. [3]
Overview
There are no established direct causes of systemic lupus erythematosus. Common contributory factors in the development of systemic lupus erythematosus include genetic predisposition, auto-immune diseases, and use of drugs. Less common factors include environmental factors and exposure to ultraviolet (UV) light.
Causes
- Genetic predisposition:[1]
- HLA class polymorphism
- Complement genes
- Female sexual gene due to high levels of estrogen and prolactin
- Auto-immune disease[2]
- Exposure to ultraviolet (UV) light[3]
- Can exacerbate or induce systemic manifestations of SLE
- Drug-induced lupus
References
- ↑ Schur PH (1995). "Genetics of systemic lupus erythematosus". Lupus. 4 (6): 425–37. doi:10.1177/096120339500400603. PMID 8749564.
- ↑ Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT (1995). "Estrogens, the immune response and autoimmunity". Clin. Exp. Rheumatol. 13 (2): 217–26. PMID 7656468.
- ↑ Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS (2002). "Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history". J Clin Epidemiol. 55 (10): 982–9. PMID 12464374.